Mutational signatures of colorectal cancers according to distinct computational workflows

Abstract Tumor mutational signatures have gained prominence in cancer research, yet the lack of standardized methods hinders reproducibility and robustness. Leveraging colorectal cancer (CRC) as a model, we explored the influence of computational parameters on mutational signature analyses across 23...

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Vydáno v:	Briefings in bioinformatics Ročník 25; číslo 4
Hlavní autoři:	Battuello, Paolo, Corti, Giorgio, Bartolini, Alice, Lorenzato, Annalisa, Sogari, Alberto, Russo, Mariangela, Di Nicolantonio, Federica, Bardelli, Alberto, Crisafulli, Giovanni
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 23.05.2024 Oxford Publishing Limited (England)
Témata:	Algorithms Cancer Cell Line, Tumor Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Computational Biology - methods Computer applications Datasets Endometrial cancer Exome Sequencing - methods Female Gene sequencing Genomic analysis Humans Impact analysis Lung cancer Mismatch repair Mutation Organoids Precision medicine Signature analysis Signatures Software Statistical analysis Uterine cancer Whole genome sequencing Workflow computational biology precision oncology colorectal cancer benchmarking mutational signatures bioinformatics genomics
ISSN:	1467-5463, 1477-4054, 1477-4054
On-line přístup:	Získat plný text
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