Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and l-dopa toxicity

► Mitochondria dysfunction-oxidative stress-apoptosis have a role in PD pathogenesis. ► α-Lipoic acid provided early neuroprotection by intervention of this pathogenesis. ► l-Dopa was found to deteriorate PD pathogenesis despite symptomatic motor relief. ► α-Lipoic acid efficiently halted the delete...

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