Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and l-dopa toxicity

► Mitochondria dysfunction-oxidative stress-apoptosis have a role in PD pathogenesis. ► α-Lipoic acid provided early neuroprotection by intervention of this pathogenesis. ► l-Dopa was found to deteriorate PD pathogenesis despite symptomatic motor relief. ► α-Lipoic acid efficiently halted the delete...

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Bibliographic Details
Published in:	Neuroscience research Vol. 71; no. 4; pp. 387 - 395
Main Authors:	Abdin, Amany A., Sarhan, Naglaa I.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.12.2011
Subjects:	Animals Antiparkinson Agents - pharmacology Apoptosis Apoptosis - drug effects Disease Models, Animal l-Dopa Levodopa - pharmacology Mitochondria - drug effects Mitochondrial dysfunction Neurons - drug effects Neurons - ultrastructure Neuroprotective Agents - pharmacology Oxidative stress Oxidative Stress - drug effects Parkinson Disease - pathology Parkinson's disease Rats Rotenone - toxicity Thioctic Acid - pharmacology Uncoupling Agents - toxicity α-Lipoic acid α-Lipoic acid Oxidative stress Parkinson's disease Mitochondrial dysfunction l-Dopa Apoptosis
ISSN:	0168-0102, 1872-8111, 1872-8111
Online Access:	Get full text
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