Developing Computational Geometry and Network Graph Models of Human Lymphatic System

The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative term...

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Published in:	Computation Vol. 6; no. 1; p. 1
Main Authors:	Tretyakova, Rufina, Savinkov, Rostislav, Lobov, Gennady, Bocharov, Gennady
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01.03.2018
Subjects:	computational algorithm Computational geometry geometric model Immune system Lymphatic system Mathematical models network graph Organs topological properties
ISSN:	2079-3197, 2079-3197
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Abstract	The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models.
AbstractList	The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models.
Author	Savinkov, Rostislav Tretyakova, Rufina Bocharov, Gennady Lobov, Gennady
Author_xml	– sequence: 1 givenname: Rufina surname: Tretyakova fullname: Tretyakova, Rufina – sequence: 2 givenname: Rostislav surname: Savinkov fullname: Savinkov, Rostislav – sequence: 3 givenname: Gennady surname: Lobov fullname: Lobov, Gennady – sequence: 4 givenname: Gennady orcidid: 0000-0002-5049-0656 surname: Bocharov fullname: Bocharov, Gennady
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SubjectTerms	computational algorithm Computational geometry geometric model Immune system Lymphatic system Mathematical models network graph Organs topological properties
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