Developing Computational Geometry and Network Graph Models of Human Lymphatic System
The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative term...
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| Vydáno v: | Computation Ročník 6; číslo 1; s. 1 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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Basel
MDPI AG
01.03.2018
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| ISSN: | 2079-3197, 2079-3197 |
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| Abstract | The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models. |
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| AbstractList | The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models. |
| Author | Savinkov, Rostislav Tretyakova, Rufina Bocharov, Gennady Lobov, Gennady |
| Author_xml | – sequence: 1 givenname: Rufina surname: Tretyakova fullname: Tretyakova, Rufina – sequence: 2 givenname: Rostislav surname: Savinkov fullname: Savinkov, Rostislav – sequence: 3 givenname: Gennady surname: Lobov fullname: Lobov, Gennady – sequence: 4 givenname: Gennady orcidid: 0000-0002-5049-0656 surname: Bocharov fullname: Bocharov, Gennady |
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| Cites_doi | 10.1146/annurev-immunol-041015-055354 10.1111/j.1440-1681.2008.05010.x 10.1371/journal.pone.0148384 10.1007/978-1-4419-8871-3_3 10.1371/journal.pcbi.1004436 10.1134/S0965542515080060 10.1007/s00285-015-0940-x 10.1051/mmnp/201611101 10.1016/j.semcdb.2014.11.012 10.1146/annurev-bioeng-112315-031200 10.3390/computation3020222 10.20944/preprints201612.0054.v1 10.1023/A:1011905604368 10.1007/s00441-003-0777-2 10.1002/wsbm.1201 10.1016/j.engappai.2016.10.007 10.1016/j.mvr.2014.06.006 10.1098/rsif.2011.0751 10.1016/0010-4825(77)90023-3 10.1371/journal.pone.0168259 10.1006/bulm.2002.0293 |
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| References | Padera (ref_3) 2016; 18 Bunicheva (ref_8) 2015; 55 Bessonov (ref_11) 2016; 11 ref_13 Liao (ref_2) 2015; 38 Margaris (ref_5) 2012; 9 Bunicheva (ref_7) 2001; 37 Nakaoka (ref_14) 2016; 72 ref_19 ref_18 Savinkov (ref_23) 2017; 62 Randolph (ref_1) 2017; 35 Kesler (ref_16) 2013; 5 McDougall (ref_28) 2002; 64 Abakumov (ref_6) 2000; 12 Jeltsch (ref_17) 2003; 314 ref_25 Munn (ref_4) 2014; 96 Borzov (ref_9) 2015; 27 ref_24 ref_21 Reddy (ref_12) 1977; 7 ref_20 Grinberg (ref_10) 2009; 36 Kislitsyn (ref_22) 2015; 3 ref_29 ref_27 Chaplain (ref_26) 2004; 117 Qatarneh (ref_15) 2006; 289 |
| References_xml | – volume: 35 start-page: 31 year: 2017 ident: ref_1 article-title: The lymphatic system: Integral roles in immunity publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev-immunol-041015-055354 – volume: 36 start-page: 194 year: 2009 ident: ref_10 article-title: Large-scale simulation of the human arterial tree publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1111/j.1440-1681.2008.05010.x – ident: ref_25 doi: 10.1371/journal.pone.0148384 – ident: ref_18 – volume: 117 start-page: 51 year: 2004 ident: ref_26 article-title: Mathematical modeling of tumour-induced angiogenesis: Network growth and structure publication-title: Cancer Treat. Res. doi: 10.1007/978-1-4419-8871-3_3 – ident: ref_21 – ident: ref_27 doi: 10.1371/journal.pcbi.1004436 – volume: 12 start-page: 106 year: 2000 ident: ref_6 article-title: Strategy of mathematical cardiovascular system modeling publication-title: Matem. Mod. – volume: 55 start-page: 1381 year: 2015 ident: ref_8 article-title: Mathematical modeling of quasi-one-dimensional hemodynamics publication-title: Comput. Math. Math. Phys. doi: 10.1134/S0965542515080060 – volume: 72 start-page: 909 year: 2016 ident: ref_14 article-title: Dynamics of HIV infection in lymphoid tissue network publication-title: J. Math. Biol. doi: 10.1007/s00285-015-0940-x – volume: 27 start-page: 3 year: 2015 ident: ref_9 article-title: Modeling of blood glucose dynamics with account of systemic loop topology publication-title: Math. Model. – volume: 11 start-page: 1 year: 2016 ident: ref_11 article-title: Methods of blood flow modeling publication-title: Math. Model. Nat. Phenom. doi: 10.1051/mmnp/201611101 – volume: 38 start-page: 83 year: 2015 ident: ref_2 article-title: Lymphatic system: An active pathway for immune protection publication-title: Semin. Cell Dev. Biol. doi: 10.1016/j.semcdb.2014.11.012 – volume: 18 start-page: 125 year: 2016 ident: ref_3 article-title: The lymphatic system in disease processes and cancer progression publication-title: Annu. Rev. Biomed. Eng. doi: 10.1146/annurev-bioeng-112315-031200 – volume: 3 start-page: 222 year: 2015 ident: ref_22 article-title: Computational approach to 3D modeling of the lymph node geometry publication-title: Computation doi: 10.3390/computation3020222 – ident: ref_24 doi: 10.20944/preprints201612.0054.v1 – volume: 37 start-page: 949 year: 2001 ident: ref_7 article-title: An Averaged Nonlinear Model of Hemodynamics on the Vessel Graph publication-title: Differ. Equ. doi: 10.1023/A:1011905604368 – volume: 314 start-page: 69 year: 2003 ident: ref_17 article-title: Genesis and pathogenesis of lymphatic vessels publication-title: Cell Tissue Res. doi: 10.1007/s00441-003-0777-2 – volume: 5 start-page: 111 year: 2013 ident: ref_16 article-title: Lymphatic vessels in health and disease publication-title: Wiley Interdiscip. Rev. Syst. Biol. Med. doi: 10.1002/wsbm.1201 – volume: 62 start-page: 341 year: 2017 ident: ref_23 article-title: Data-driven modeling of the FRC network for studying the fluid flow in the conduit system publication-title: Eng. Appl. Artif. Intell. doi: 10.1016/j.engappai.2016.10.007 – volume: 289 start-page: 98 year: 2006 ident: ref_15 article-title: Three-dimensional atlas of lymph node topography based on the visible human data set publication-title: Anat. Rec. Part B New Anat. – volume: 96 start-page: 55 year: 2014 ident: ref_4 article-title: Imaging the lymphatic system publication-title: Microvasc. Res. doi: 10.1016/j.mvr.2014.06.006 – ident: ref_13 – ident: ref_19 – volume: 9 start-page: 601 year: 2012 ident: ref_5 article-title: Modeling the lymphatic system: Challenges and opportunities publication-title: J. R. Soc. Interface doi: 10.1098/rsif.2011.0751 – ident: ref_20 – volume: 7 start-page: 181 year: 1977 ident: ref_12 article-title: A computer model of the lymphatic system publication-title: Comput. Biol. Med. doi: 10.1016/0010-4825(77)90023-3 – ident: ref_29 doi: 10.1371/journal.pone.0168259 – volume: 64 start-page: 673 year: 2002 ident: ref_28 article-title: Mathematical modeling of flow through vascular networks: Implications for tumour-induced angiogenesis and chemotherapy strategies publication-title: Bull. Math. Biol. doi: 10.1006/bulm.2002.0293 |
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