Developing Computational Geometry and Network Graph Models of Human Lymphatic System

The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative term...

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Veröffentlicht in:Computation Jg. 6; H. 1; S. 1
Hauptverfasser: Tretyakova, Rufina, Savinkov, Rostislav, Lobov, Gennady, Bocharov, Gennady
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 01.03.2018
Schlagworte:
computational algorithm
Computational geometry
geometric model
Immune system
Lymphatic system
Mathematical models
network graph
Organs
topological properties
ISSN:2079-3197, 2079-3197
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Zusammenfassung:The lymphatic system is a body-wide network of lymphatic vessels and lymphoid organs. The complexity of the structural and functional organization of the lymphatic system implies the necessity of using computational modeling approaches to unravel the mechanisms of its regulation in quantitative terms. Although it is a vital part of the circulatory and immune systems, the lymphatic system remains poorly investigated as a mathematical modeling object. Modeling of the lymphatic vessel network needs to be established using a systematic approach in order to advance the model-driven research of this important physiological system. In our study, we elucidate key general features underlying the 3D structural organization of the lymphatic system in order to develop computational geometry and network graph models of the human lymphatic system based on available anatomical data (from the PlasticBoy project), which provides an estimate of the structure of the lymphatic system, and to analyze the topological properties of the resulting models.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2079-3197
2079-3197
DOI:10.3390/computation6010001