Chromatin position effects assayed by thousands of reporters integrated in parallel

Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here, we describe a multiplexing approach for the parallel monitoring of transcript...

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Vydané v:	Cell Ročník 154; číslo 4; s. 914
Hlavní autori:	Akhtar, Waseem, de Jong, Johann, Pindyurin, Alexey V, Pagie, Ludo, Meuleman, Wouter, de Ridder, Jeroen, Berns, Anton, Wessels, Lodewyk F A, van Lohuizen, Maarten, van Steensel, Bas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.08.2013
Predmet:	Animals Chromatin - metabolism Chromosomal Position Effects Embryonic Stem Cells - metabolism Genes, Reporter Genetic Techniques High-Throughput Nucleotide Sequencing Mice Promoter Regions, Genetic
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
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