CAR-T cell manufacturing: Major process parameters and next-generation strategies

Chimeric antigen receptor (CAR)-T cell therapies have demonstrated strong curative potential and become a critical component in the array of B-cell malignancy treatments. Successful deployment of CAR-T cell therapies to treat hematologic and solid cancers, as well as other indications such as autoim...

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Bibliographic Details
Published in:The Journal of experimental medicine Vol. 221; no. 2
Main Authors: Ayala Ceja, Melanie, Khericha, Mobina, Harris, Caitlin M, Puig-Saus, Cristina, Chen, Yvonne Y
Format: Journal Article
Language:English
Published: United States 05.02.2024
Subjects:
Autoimmune Diseases
Humans
Immunotherapy, Adoptive
T-Lymphocytes
ISSN:1540-9538, 1540-9538
Online Access:Get more information
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Summary:Chimeric antigen receptor (CAR)-T cell therapies have demonstrated strong curative potential and become a critical component in the array of B-cell malignancy treatments. Successful deployment of CAR-T cell therapies to treat hematologic and solid cancers, as well as other indications such as autoimmune diseases, is dependent on effective CAR-T cell manufacturing that impacts not only product safety and efficacy but also overall accessibility to patients in need. In this review, we discuss the major process parameters of autologous CAR-T cell manufacturing, as well as regulatory considerations and ongoing developments that will enable the next generation of CAR-T cell therapies.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1540-9538
1540-9538
DOI:10.1084/jem.20230903