Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses

Mucosal-associated invariant T (MAIT) cells use canonical semi-invariant T cell receptors (TCR) to recognize microbial riboflavin precursors displayed by the antigen-presenting molecule MR1. The extent of MAIT TCR crossreactivity toward physiological, microbially unrelated antigens remains underexpl...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 220; H. 9
Hauptverfasser:	Chancellor, Andrew, Alan Simmons, Robert, Khanolkar, Rahul C, Nosi, Vladimir, Beshirova, Aisha, Berloffa, Giuliano, Colombo, Rodrigo, Karuppiah, Vijaykumar, Pentier, Johanne M, Tubb, Vanessa, Ghadbane, Hemza, Suckling, Richard J, Page, Keith, Crean, Rory M, Vacchini, Alessandro, De Gregorio, Corinne, Schaefer, Verena, Constantin, Daniel, Gligoris, Thomas, Lloyd, Angharad, Hock, Miriam, Srikannathasan, Velupillai, Robinson, Ross A, Besra, Gurdyal S, van der Kamp, Marc W, Mori, Lucia, Calogero, Raffaele, Cole, David K, De Libero, Gennaro, Lepore, Marco
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 04.09.2023
Schlagworte:	Cell Communication Cell Membrane Cross Reactions DNA Repair Histocompatibility Antigens Class I Humans Minor Histocompatibility Antigens Mucosal-Associated Invariant T Cells
ISSN:	1540-9538, 1540-9538
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