Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases
The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dement...
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| Vydané v: | Journal of Alzheimer's disease Ročník 62; číslo 1; s. 247 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Netherlands
01.01.2018
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| ISSN: | 1875-8908, 1875-8908 |
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| Abstract | The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. |
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| AbstractList | The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers.The present study tested the hypothesis that cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and dementia with Lewy bodies (DLBMCI) as compared to cognitively normal elderly (Nold) subjects. Clinical and rsEEG data in 30 ADMCI, 23 DLBMCI, and 30 Nold subjects were available in an international archive. Age, gender, and education were carefully matched in the three groups. The Mini-Mental State Evaluation (MMSE) score was matched between the ADMCI and DLBMCI groups. Individual alpha frequency peak (IAF) was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were also considered. eLORETA estimated the rsEEG cortical sources. Receiver operating characteristic curve (ROCC) classified these sources across individuals. Compared to Nold, IAF showed marked slowing in DLBMCI and moderate in ADMCI. Furthermore, the posterior alpha 2 and alpha 3 source activities were more abnormal in the ADMCI than the DLBMCI group, while widespread delta source activities were more abnormal in the DLBMCI than the ADMCI group. The posterior delta and alpha sources correlated with the MMSE score and correctly classified the Nold and MCI individuals (area under the ROCC >0.85). In conclusion, the ADMCI and DLBMCI patients showed different features of cortical neural synchronization at delta and alpha frequencies underpinning brain arousal and vigilance in the quiet wakefulness. Future prospective cross-validation studies will have to test the clinical validity of these rsEEG markers. |
| Author | Başar, Erol Lizio, Roberta Pascarelli, Maria Teresa Emek-Savaş, Derya Durusu Stocchi, Fabrizio Bonanni, Laura Stirpe, Paola Orzi, Francesco Arnaldi, Dario De Lena, Carlo Hanoğlu, Lutfu D'Antonio, Fabrizia Buttinelli, Carla Onofrj, Marco Nobili, Flavio Garn, Heinrich Yener, Görsev Gschwandtner, Ute Ransmayr, Gerhard Aarsland, Dag Del Percio, Claudio Fraioli, Lucia Taylor, John Paul Lopez, Susanna Vacca, Laura Triggiani, Antonio Ivano Babiloni, Claudio Ferri, Raffaele Catania, Valentina Fuhr, Peter Giubilei, Franco Franciotti, Raffaella Soricelli, Andrea Famà, Francesco Pievani, Michela Güntekin, Bahar De Pandis, Maria Francesca Noce, Giuseppe Frisoni, Giovanni B |
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University of Naples Parthenope, Naples, Italy – sequence: 7 givenname: Raffaele surname: Ferri fullname: Ferri, Raffaele organization: Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy – sequence: 8 givenname: Maria Teresa surname: Pascarelli fullname: Pascarelli, Maria Teresa organization: Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy – sequence: 9 givenname: Valentina surname: Catania fullname: Catania, Valentina organization: Department of Neurology, IRCCS Oasi Institute for Research on Mental Retardation and Brain Aging, Troina, Enna, Italy – sequence: 10 givenname: Flavio surname: Nobili fullname: Nobili, Flavio organization: Department of Neuroscience (DiNOGMI), Clinical Neurology, University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy – sequence: 11 givenname: Dario surname: Arnaldi fullname: Arnaldi, Dario organization: Department of Neuroscience (DiNOGMI), Clinical Neurology, University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy – sequence: 12 givenname: Francesco surname: Famà fullname: Famà, Francesco organization: Department of Neuroscience (DiNOGMI), Clinical Neurology, University of Genoa and IRCCS AOU S Martino-IST, Genoa, Italy – sequence: 13 givenname: Dag surname: Aarsland fullname: Aarsland, Dag organization: Department of Old Age Psychiatry, King's College University, London, UK – sequence: 14 givenname: Francesco surname: Orzi fullname: Orzi, Francesco organization: Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy – sequence: 15 givenname: Carla surname: Buttinelli fullname: Buttinelli, Carla organization: Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy – sequence: 16 givenname: Franco surname: Giubilei fullname: Giubilei, Franco organization: Department of Neuroscience, Mental Health and Sensory Organs, University of Rome "La Sapienza", Rome, Italy – sequence: 17 givenname: Marco surname: Onofrj fullname: Onofrj, Marco organization: Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy – sequence: 18 givenname: Fabrizio surname: Stocchi fullname: Stocchi, Fabrizio organization: Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy – sequence: 19 givenname: Laura surname: Vacca fullname: Vacca, Laura organization: Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy – sequence: 20 givenname: Paola surname: Stirpe fullname: Stirpe, Paola organization: Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy – sequence: 21 givenname: Peter surname: Fuhr fullname: Fuhr, Peter organization: Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland – sequence: 22 givenname: Ute surname: Gschwandtner fullname: Gschwandtner, Ute organization: Universitätsspital Basel, Abteilung Neurophysiologie, Basel, Switzerland – sequence: 23 givenname: Gerhard surname: Ransmayr fullname: Ransmayr, Gerhard organization: Department of Neurology 2, Med Campus III, Kepler University Hospital, Medical Faculty of the Johannes Kepler University, Linz, Austria – sequence: 24 givenname: Heinrich surname: Garn fullname: Garn, Heinrich organization: AIT Austrian Institute of Technology GmbH, Vienna, Austria – sequence: 25 givenname: Lucia surname: Fraioli fullname: Fraioli, Lucia organization: Hospital San Raffaele of Cassino, Italy – sequence: 26 givenname: Michela surname: Pievani fullname: Pievani, Michela organization: Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy – sequence: 27 givenname: Giovanni B surname: Frisoni fullname: Frisoni, Giovanni B organization: Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland – sequence: 28 givenname: Fabrizia surname: D'Antonio fullname: D'Antonio, Fabrizia organization: Department of Neurology and Psychiatry, Sapienza, University of Rome, Italy – sequence: 29 givenname: Carlo surname: De Lena fullname: De Lena, Carlo organization: Department of Neurology and Psychiatry, Sapienza, University of Rome, Italy – sequence: 30 givenname: Bahar surname: Güntekin fullname: Güntekin, Bahar organization: Department of Biophysics, Istanbul Medipol University, Istanbul, Turkey – sequence: 31 givenname: Lutfu surname: Hanoğlu fullname: Hanoğlu, Lutfu organization: Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey – sequence: 32 givenname: Erol surname: Başar fullname: Başar, Erol organization: IBG, Departments of Neurology and Neurosciences, Dokuz Eylül University, Izmir, Turkey – sequence: 33 givenname: Görsev surname: Yener fullname: Yener, Görsev organization: IBG, Departments of Neurology and Neurosciences, Dokuz Eylül University, Izmir, Turkey – sequence: 34 givenname: Derya Durusu surname: Emek-Savaş fullname: Emek-Savaş, Derya Durusu organization: Department of Psychology and Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey – sequence: 35 givenname: Antonio Ivano surname: Triggiani fullname: Triggiani, Antonio Ivano organization: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy – sequence: 36 givenname: Raffaella surname: Franciotti fullname: Franciotti, Raffaella organization: Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy – sequence: 37 givenname: John Paul surname: Taylor fullname: Taylor, John Paul organization: Institute of Neuroscience, Newcastle University, Newcastle, UK – sequence: 38 givenname: Maria Francesca surname: De Pandis fullname: De Pandis, Maria Francesca organization: Hospital San Raffaele of Cassino, Italy – sequence: 39 givenname: Laura surname: Bonanni fullname: Bonanni, Laura organization: Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy |
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| Keywords | mild cognitive impairment due to dementia with Lewy bodies receiver operating characteristic curve resting state electroencephalographic rhythms Exact low resolution brain electromagnetic source tomography (eLORETA) mild cognitive impairment due to Alzheimer’s disease |
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| SubjectTerms | Aged Alzheimer Disease - complications Alzheimer Disease - diagnosis Alzheimer Disease - drug therapy Alzheimer Disease - physiopathology Brain - drug effects Brain - physiopathology Cognitive Dysfunction - diagnosis Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Educational Status Electroencephalography Female Humans Lewy Body Disease - complications Lewy Body Disease - diagnosis Lewy Body Disease - drug therapy Lewy Body Disease - physiopathology Male Psychotropic Drugs - therapeutic use Rest Retrospective Studies Signal Processing, Computer-Assisted |
| Title | Abnormalities of Resting State Cortical EEG Rhythms in Subjects with Mild Cognitive Impairment Due to Alzheimer's and Lewy Body Diseases |
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