A positive allosteric modulator of mGlu4 receptors restores striatal plasticity in an animal model of l-Dopa-induced dyskinesia

By decreasing glutamate transmission, mGlu4 receptor positive allosteric modulators (mGlu4-PAM), in combination with levodopa (l-DOPA) may restore the synergy between glutamatergic and dopaminergic transmissions, thus maximizing the improvement of motor function in Parkinson's disease (PD). Thi...

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Bibliographic Details
Published in:	Neuropharmacology Vol. 218; p. 109205
Main Authors:	Calabrese, Valeria, Picconi, Barbara, Heck, Nicolas, Campanelli, Federica, Natale, Giuseppina, Marino, Gioia, Sciaccaluga, Miriam, Ghiglieri, Veronica, Tozzi, Alessandro, Anceaume, Estelle, Cuoc, Emeline, Caboche, Jocelyne, Conquet, François, Calabresi, Paolo, Charvin, Delphine
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.11.2022 Elsevier
Subjects:	Basal ganglia Dyskinesia Glutamate Life Sciences mGlu4 Movement disorder Positive allosteric modulator Spines Striatum Synaptic plasticity mGlu4 Striatum Basal ganglia Movement disorder Synaptic plasticity Positive allosteric modulator Glutamate Spines Dyskinesia Dyskinesia Glutamate Synaptic plasticity mGlu4 Spines Basal ganglia Striatum Positive allosteric modulator Movement disorder
ISSN:	0028-3908, 1873-7064, 1873-7064
Online Access:	Get full text
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