Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies

To develop a transgenic mouse model of glioma that can be conveniently used for testing therapy intervention strategies. High-grade glioma is a devastating and uniformly fatal disease for which better therapy is urgently needed. Typical for high-grade glioma is that glioma cells infiltrate extensive...

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Veröffentlicht in:	Clinical cancer research Jg. 16; H. 13; S. 3431
Hauptverfasser:	de Vries, Nienke A, Bruggeman, Sophia W, Hulsman, Danielle, de Vries, Hilda I, Zevenhoven, John, Buckle, Tessa, Hamans, Bob C, Leenders, William P, Beijnen, Jos H, van Lohuizen, Maarten, Berns, Anton J M, van Tellingen, Olaf
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2010
Schlagworte:	ADP-Ribosylation Factors - genetics Animals Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - therapy Disease Models, Animal Genes, p16 Genes, p53 Genetic Vectors Glioma - genetics Glioma - pathology Glioma - therapy Lentivirus - genetics Mice Mice, Transgenic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) PTEN Phosphohydrolase - genetics ras Proteins - genetics Transfection
ISSN:	1078-0432, 1557-3265, 1557-3265
Online-Zugang:	Weitere Angaben
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