Electropysiologic evaluation of the visual pathway in patients with multiple sclerosis

To evaluate the ability of visual evoked potentials and pattern electroretinograms (PERG) to detect subclinical axonal damage in patients during the early diagnostic stage of multiple sclerosis (MS). The authors also compared the ability of optical coherence tomography (OCT), PERG, and visual evoked...

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Bibliographic Details
Published in:Journal of clinical neurophysiology Vol. 30; no. 4; p. 376
Main Authors: Rodriguez-Mena, Diego, Almarcegui, Carmen, Dolz, Isabel, Herrero, Raquel, Bambo, Maria P, Fernandez, Javier, Pablo, Luis E, Garcia-Martin, Elena
Format: Journal Article
Language:English
Published: United States 01.08.2013
Subjects:
Adult
Axons - pathology
Axons - physiology
Cross-Sectional Studies
Electroretinography - instrumentation
Electroretinography - methods
Evoked Potentials, Visual - physiology
Female
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - pathology
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Nerve Fibers - pathology
Occipital Lobe - pathology
Occipital Lobe - physiopathology
Prospective Studies
Retina - pathology
Retina - physiopathology
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - methods
Vision Tests
Visual Pathways - pathology
Visual Pathways - physiopathology
ISSN:1537-1603, 1537-1603
Online Access:Get more information
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Summary:To evaluate the ability of visual evoked potentials and pattern electroretinograms (PERG) to detect subclinical axonal damage in patients during the early diagnostic stage of multiple sclerosis (MS). The authors also compared the ability of optical coherence tomography (OCT), PERG, and visual evoked potentials to detect axonal loss in MS patients and correlated the functional and structural properties of the retinal nerve fiber layer. Two hundred twenty-eight eyes of 114 subjects (57 MS patients and 57 age- and sex-matched healthy controls) were included. The visual pathway was evaluated based on functional and structural assessments. All patients underwent a complete ophthalmic examination that included assessment of visual acuity, ocular motility, intraocular pressure, visual field, papillary morphology, OCT, visual evoked potentials, and PERG. Visual evoked potentials (P100 latency and amplitude), PERG (N95 amplitude and N95/P50 ratio), and OCT parameters differed significantly between MS patients and healthy subjects. Moderate significant correlations were found between visual evoked potentials or PERG parameters and OCT measurements. Axonal damage in ganglion cells of the visual pathway can be detected based on structural measures provided by OCT in MS patients and by the N95 component and N95/P50 index of PERG, thus providing good correlation between function and structure.
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ISSN:1537-1603
1537-1603
DOI:10.1097/WNP.0b013e31829d75f7