A microglia clonal inflammatory disorder in Alzheimer’s disease

Somatic genetic heterogeneity resulting from post-zygotic DNA mutations is widespread in human tissues and can cause diseases, however, few studies have investigated its role in neurodegenerative processes such as Alzheimer’s disease (AD). Here, we report the selective enrichment of microglia clones...

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Veröffentlicht in:	eLife Jg. 13; H. 2
Hauptverfasser:	Vicario, Rocio, Fragkogianni, Stamatina, Weber, Leslie, Lazarov, Tomi, Hu, Yang, Hayashi, Samantha Y, Craddock, Barbara, Socci, Nicholas D, Alberdi, Araitz, Baako, Ann, Ay, Oyku, Ogishi, Masato, Lopez-Rodrigo, Estibaliz, Kappagantula, Rajya, Viale, Agnes, Iacobuzio-Donahue, Christine A, Zhou, Ting, Ransohoff, Richard M, Chesworth, Richard, Abdel-Wahab, Omar, Boisson, Bertrand, Elemento, Olivier, Casanova, Jean-Laurent, Miller, W Todd, Geissmann, Frédéric
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Sciences Publications Ltd 14.03.2025 eLife Sciences Publication
Schlagworte:	Aged Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Animals Blood cells Brain Brain injury Cell death Cloning Female Flow cytometry Genetic testing Humans Inflammation - pathology Inflammatory diseases Life Sciences Male MAP kinase Mice Microglia Microglia - metabolism Microglia - pathology Mutation Neurodegeneration Neurodegenerative diseases Neuronal-glial interactions somatic mutations Stromal cells Tissues somatic mutations inflammation neuroscience map kinase Alzheimer's disease human immunology microglia
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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