HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading

Class II molecules of the major histocompatibility complex become loaded with antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the peptide-binding groove. The human leukocyte antigen (HLA)-DM is a prerequisite for this process, which takes place in specialised int...

Full description

Bibliographic Details

Published in:	Current biology Vol. 7; no. 12; p. 950
Main Authors:	van Ham, S M, Tjin, E P, Lillemeier, B F, Grüneberg, U, van Meijgaarden, K E, Pastoors, L, Verwoerd, D, Tulp, A, Canas, B, Rahman, D, Ottenhoff, T H, Pappin, D J, Trowsdale, J, Neefjes, J
Format:	Journal Article
Language:	English
Published:	England 01.12.1997
Subjects:	Amino Acid Sequence Antigen Presentation Antigens, Differentiation, B-Lymphocyte - metabolism Cell Line Histocompatibility Antigens Class II - metabolism HLA-D Antigens - genetics HLA-D Antigens - metabolism HLA-DR3 Antigen - metabolism Humans Molecular Sequence Data Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Transfection
ISSN:	0960-9822
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!