Prolonged ventricular asystole: a rare adverse effect of hydrocodone use

Prolonged ventricular asystole is a rare vagal reaction caused by hydrocodone use. Sinus bradycardia is a characteristic presentation of the vasovagal response; examples of other presentations include arrest or atrioventricular block. Physicians need to be aware of ventricular asystole due to vagall...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of case reports Vol. 15; p. 450
Main Authors: Sudhakaran, Sivakumar, Surani, Saherish S, Surani, Salim R
Format: Journal Article
Language:English
Published: United States 21.10.2014
Subjects:
Analgesics, Opioid - adverse effects
Analgesics, Opioid - therapeutic use
Electrocardiography
Female
Heart Arrest - chemically induced
Heart Arrest - diagnosis
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
Humans
Hydrocodone - adverse effects
Hydrocodone - therapeutic use
Middle Aged
Syncope, Vasovagal - chemically induced
Syncope, Vasovagal - diagnosis
Syncope, Vasovagal - physiopathology
ISSN:1941-5923, 1941-5923
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Prolonged ventricular asystole is a rare vagal reaction caused by hydrocodone use. Sinus bradycardia is a characteristic presentation of the vasovagal response; examples of other presentations include arrest or atrioventricular block. Physicians need to be aware of ventricular asystole due to vagally-mediated atrioventricular block caused by hydrocodone or other opiates. We present a case of prolonged ventricular asystole in a young patient due to a vasovagal reaction caused by the hydrocodone found in the hydrocodone/acetaminophen combination. Ventricular asystole can be a rare complication of hydrocodone found in hydrocodone/acetaminophen. Physicians need to be aware of this adverse effect, rather then resorting to expensive diagnostic interventions.
AbstractList Prolonged ventricular asystole is a rare vagal reaction caused by hydrocodone use. Sinus bradycardia is a characteristic presentation of the vasovagal response; examples of other presentations include arrest or atrioventricular block. Physicians need to be aware of ventricular asystole due to vagally-mediated atrioventricular block caused by hydrocodone or other opiates. We present a case of prolonged ventricular asystole in a young patient due to a vasovagal reaction caused by the hydrocodone found in the hydrocodone/acetaminophen combination. Ventricular asystole can be a rare complication of hydrocodone found in hydrocodone/acetaminophen. Physicians need to be aware of this adverse effect, rather then resorting to expensive diagnostic interventions.
Prolonged ventricular asystole is a rare vagal reaction caused by hydrocodone use. Sinus bradycardia is a characteristic presentation of the vasovagal response; examples of other presentations include arrest or atrioventricular block. Physicians need to be aware of ventricular asystole due to vagally-mediated atrioventricular block caused by hydrocodone or other opiates.BACKGROUNDProlonged ventricular asystole is a rare vagal reaction caused by hydrocodone use. Sinus bradycardia is a characteristic presentation of the vasovagal response; examples of other presentations include arrest or atrioventricular block. Physicians need to be aware of ventricular asystole due to vagally-mediated atrioventricular block caused by hydrocodone or other opiates.We present a case of prolonged ventricular asystole in a young patient due to a vasovagal reaction caused by the hydrocodone found in the hydrocodone/acetaminophen combination.CASE REPORTWe present a case of prolonged ventricular asystole in a young patient due to a vasovagal reaction caused by the hydrocodone found in the hydrocodone/acetaminophen combination.Ventricular asystole can be a rare complication of hydrocodone found in hydrocodone/acetaminophen. Physicians need to be aware of this adverse effect, rather then resorting to expensive diagnostic interventions.CONCLUSIONSVentricular asystole can be a rare complication of hydrocodone found in hydrocodone/acetaminophen. Physicians need to be aware of this adverse effect, rather then resorting to expensive diagnostic interventions.
Author Surani, Salim R
Surani, Saherish S
Sudhakaran, Sivakumar
Author_xml – sequence: 1
  givenname: Sivakumar
  surname: Sudhakaran
  fullname: Sudhakaran, Sivakumar
  organization: Department of Medicine, Texas A&M University Health Science Center, College Station, USA
– sequence: 2
  givenname: Saherish S
  surname: Surani
  fullname: Surani, Saherish S
  organization: Research Assistant, Pulmonary Associates of Corpus Christi, Aransas Pass, USA
– sequence: 3
  givenname: Salim R
  surname: Surani
  fullname: Surani, Salim R
  organization: Department of Medicine, Texas A&M University Health Science Center, College Station, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25330933$$D View this record in MEDLINE/PubMed
BookMark eNpNj81LAzEUxIMottbePEuOXrZuXj66660UtUpBET0v2ZcXrWw3Ndkt9L-3YgXnMnP4McycseM2tMTYhcgnAowur2eP85dJUQoQ6ogNRalEpkuQx__ygI1T-sz3MmCmIE_ZALSUeSnlkC2eY2hC-06Ob6nt4gr7xkZu0y51oaEbbnm0kbh1W4qJOHlP2PHg-cfOxYDB7QfxPtE5O_G2STQ--Ii93d2-zhfZ8un-YT5bZigL1WVO49RrjdqDVw601SZHKTBHpELWEpQzpa1rN83BOmdRYIGqFoX0SIACRuzqt3cTw1dPqavWq4TUNLal0KdKGKFBG6l-0MsD2tdrctUmrtY27qq_9_ANijBe3A
CitedBy_id crossref_primary_10_1001_jamainternmed_2020_8601
crossref_primary_10_1016_j_ajem_2017_04_069
crossref_primary_10_1007_s40278_014_5112_z
crossref_primary_10_1111_pme_12915
crossref_primary_10_3390_cimb47050299
crossref_primary_10_1007_s40264_021_01115_6
crossref_primary_10_1016_j_jeurea_2016_02_005
ContentType Journal Article
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.12659/AJCR.891214
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod no_fulltext_linktorsrc
Discipline Medicine
EISSN 1941-5923
ExternalDocumentID 25330933
Genre Journal Article
Case Reports
GroupedDBID ---
53G
ABDBF
ADBBV
ADRAZ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CGR
CUY
CVF
DIK
ECM
EIF
HYE
KQ8
M48
NPM
OK1
P6G
RPM
7X8
ID FETCH-LOGICAL-c384t-d5c7f55c5f2f4d25a560c31c0cce83b324d69abbd702addac1c8c4b183fce2c12
IEDL.DBID 7X8
ISICitedReferencesCount 7
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000421338500103&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1941-5923
IngestDate Fri Jul 11 11:00:07 EDT 2025
Mon Jul 21 06:07:13 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c384t-d5c7f55c5f2f4d25a560c31c0cce83b324d69abbd702addac1c8c4b183fce2c12
Notes ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
OpenAccessLink http://doi.org/10.12659/AJCR.891214
PMID 25330933
PQID 1615256341
PQPubID 23479
ParticipantIDs proquest_miscellaneous_1615256341
pubmed_primary_25330933
PublicationCentury 2000
PublicationDate 2014-10-21
PublicationDateYYYYMMDD 2014-10-21
PublicationDate_xml – month: 10
  year: 2014
  text: 2014-10-21
  day: 21
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The American journal of case reports
PublicationTitleAlternate Am J Case Rep
PublicationYear 2014
References 19713422 - Eur Heart J. 2009 Nov;30(21):2631-71
11694895 - Can J Cardiol. 2001 Oct;17(10):1051-7
20718882 - Intern Med J. 2010 Aug;40(8):554-60
1661644 - Clin Sci (Lond). 1991 Nov;81(5):575-86
17726043 - Europace. 2007 Oct;9(10):959-98
17074006 - J Cardiovasc Electrophysiol. 2006 Nov;17(11):1172-6
8876862 - Ann Pharmacother. 1996 Sep;30(9):994-1005
21160608 - World J Cardiol. 2010 Oct 26;2(10):308-15
24794249 - Auton Neurosci. 2014 Sep;184:60-5
8273729 - Am Heart J. 1994 Jan;127(1):103-11
23286970 - Heart. 2013 Jul;99(13):904-8
19763198 - Indian Pacing Electrophysiol J. 2009 Sep 01;9(5):283
10678294 - Pharmacotherapy. 2000 Feb;20(2):158-65
15721118 - Am J Cardiol. 2005 Mar 1;95(5):668-71
12715855 - Pacing Clin Electrophysiol. 2003 Apr;26(4 Pt 1):914-7
References_xml – reference: 1661644 - Clin Sci (Lond). 1991 Nov;81(5):575-86
– reference: 15721118 - Am J Cardiol. 2005 Mar 1;95(5):668-71
– reference: 8876862 - Ann Pharmacother. 1996 Sep;30(9):994-1005
– reference: 19713422 - Eur Heart J. 2009 Nov;30(21):2631-71
– reference: 8273729 - Am Heart J. 1994 Jan;127(1):103-11
– reference: 23286970 - Heart. 2013 Jul;99(13):904-8
– reference: 21160608 - World J Cardiol. 2010 Oct 26;2(10):308-15
– reference: 20718882 - Intern Med J. 2010 Aug;40(8):554-60
– reference: 10678294 - Pharmacotherapy. 2000 Feb;20(2):158-65
– reference: 11694895 - Can J Cardiol. 2001 Oct;17(10):1051-7
– reference: 17726043 - Europace. 2007 Oct;9(10):959-98
– reference: 12715855 - Pacing Clin Electrophysiol. 2003 Apr;26(4 Pt 1):914-7
– reference: 17074006 - J Cardiovasc Electrophysiol. 2006 Nov;17(11):1172-6
– reference: 24794249 - Auton Neurosci. 2014 Sep;184:60-5
– reference: 19763198 - Indian Pacing Electrophysiol J. 2009 Sep 01;9(5):283
SSID ssj0000626723
Score 1.9902767
Snippet Prolonged ventricular asystole is a rare vagal reaction caused by hydrocodone use. Sinus bradycardia is a characteristic presentation of the vasovagal...
SourceID proquest
pubmed
SourceType Aggregation Database
Index Database
StartPage 450
SubjectTerms Analgesics, Opioid - adverse effects
Analgesics, Opioid - therapeutic use
Electrocardiography
Female
Heart Arrest - chemically induced
Heart Arrest - diagnosis
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
Humans
Hydrocodone - adverse effects
Hydrocodone - therapeutic use
Middle Aged
Syncope, Vasovagal - chemically induced
Syncope, Vasovagal - diagnosis
Syncope, Vasovagal - physiopathology
Title Prolonged ventricular asystole: a rare adverse effect of hydrocodone use
URI https://www.ncbi.nlm.nih.gov/pubmed/25330933
https://www.proquest.com/docview/1615256341
Volume 15
WOSCitedRecordID wos000421338500103&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings 1
isFullTextHit
isPrint
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx_agvVvAaze4m2Y0XKcVSxJYiCr2FzexGBUlq0wr-e2eTVE-C4CW3Jcsw8803j50h5CKMIyV5hIakAu4FHHwvVdZ6oLJUKqMFM9V0_Xs5HKrxOB41CbeyaatcYGIF1KYAlyO_cswE3TOC7s3k3XNbo1x1tVmhsUxaAqmM02o5Vt85Fh_Zuqw2vGGozrwQyUzT-86jML7q3HUfLlXMuHvC8xu_rPxMb_O_N9wiGw3DpJ1aJbbJks13yNqgqaHvkv5oioCXP1tDXa9jlQDUU6rdTOfizV5TTTGAtlS7Vc2lpXXHBy0y-vJp0N1hHJtbOi_tHnnq3T52-16zT8EDoYKZZ0KQWRhCmPEsMDzUyHZAMPABrBIpUisTxTpNjfQ5wp4GBgqCFI0-A8uB8X2ykuMvDgm1qc4wtOUGCV8QWaYDqaWfMoPhCjBftMn5QkYJ6qsrQujcFvMy-ZFSmxzUgk4m9WCNhLtW11iIoz-cPibryF0C50Y4OyGtDK3VnpJV-Ji9ltOzShHwOxwNvgDYkr1X
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prolonged+ventricular+asystole%3A+a+rare+adverse+effect+of+hydrocodone+use&rft.jtitle=The+American+journal+of+case+reports&rft.au=Sudhakaran%2C+Sivakumar&rft.au=Surani%2C+Saherish+S&rft.au=Surani%2C+Salim+R&rft.date=2014-10-21&rft.issn=1941-5923&rft.eissn=1941-5923&rft.volume=15&rft.spage=450&rft_id=info:doi/10.12659%2FAJCR.891214&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1941-5923&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1941-5923&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1941-5923&client=summon