Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomi...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 218; no. 8
Main Authors:	Cheemarla, Nagarjuna R, Watkins, Timothy A, Mihaylova, Valia T, Wang, Bao, Zhao, Dejian, Wang, Guilin, Landry, Marie L, Foxman, Ellen F
Format:	Journal Article
Language:	English
Published:	United States 02.08.2021
Subjects:	Adult Aged Aged, 80 and over Angiotensin-Converting Enzyme 2 - genetics Case-Control Studies Chemokine CXCL10 - metabolism COVID-19 - immunology COVID-19 - virology Disease Susceptibility - immunology Female Gene Expression Profiling Host-Pathogen Interactions - physiology Humans Immunity, Innate - physiology Interferons - genetics Interferons - immunology Interferons - metabolism Male Middle Aged Nasopharynx - virology Picornaviridae Infections - immunology Picornaviridae Infections - virology SARS-CoV-2 - genetics SARS-CoV-2 - physiology Viral Load Virus Replication
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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