AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production

Mammalian circRNAs can influence different cellular processes by interacting with proteins and other nucleic acids. Here, we used ribonucleoprotein immunoprecipitation (RIP) analysis to identify systematically the circRNAs associated with the cancer-related protein AUF1. Among the circRNAs interacti...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 49; no. 3; pp. 1631 - 1646
Main Authors:	Tsitsipatis, Dimitrios, Grammatikakis, Ioannis, Driscoll, Riley K, Yang, Xiaoling, Abdelmohsen, Kotb, Harris, Sophia C, Yang, Jen-Hao, Herman, Allison B, Chang, Ming-Wen, Munk, Rachel, Martindale, Jennifer L, Mazan-Mamczarz, Krystyna, De, Supriyo, Lal, Ashish, Gorospe, Myriam
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 22.02.2021
Subjects:	3' Untranslated Regions Binding Sites Cell Proliferation - genetics Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism HeLa Cells Heterogeneous Nuclear Ribonucleoprotein D0 - metabolism Humans RNA and RNA-protein complexes RNA, Circular - chemistry RNA, Circular - metabolism RNA, Messenger - metabolism
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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