AUF1 ligand circPCNX reduces cell proliferation by competing with p21 mRNA to increase p21 production

Mammalian circRNAs can influence different cellular processes by interacting with proteins and other nucleic acids. Here, we used ribonucleoprotein immunoprecipitation (RIP) analysis to identify systematically the circRNAs associated with the cancer-related protein AUF1. Among the circRNAs interacti...

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Vydáno v:	Nucleic acids research Ročník 49; číslo 3; s. 1631 - 1646
Hlavní autoři:	Tsitsipatis, Dimitrios, Grammatikakis, Ioannis, Driscoll, Riley K, Yang, Xiaoling, Abdelmohsen, Kotb, Harris, Sophia C, Yang, Jen-Hao, Herman, Allison B, Chang, Ming-Wen, Munk, Rachel, Martindale, Jennifer L, Mazan-Mamczarz, Krystyna, De, Supriyo, Lal, Ashish, Gorospe, Myriam
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 22.02.2021
Témata:	3' Untranslated Regions Binding Sites Cell Proliferation - genetics Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism HeLa Cells Heterogeneous Nuclear Ribonucleoprotein D0 - metabolism Humans RNA and RNA-protein complexes RNA, Circular - chemistry RNA, Circular - metabolism RNA, Messenger - metabolism
ISSN:	0305-1048, 1362-4962, 1362-4962
On-line přístup:	Získat plný text
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