Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice

In this study, using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, we characterized the heterogeneity of polymorphonuclear neutrophils (PMNs) in cancer. We describe three populations of PMNs in tumor-bearing mice: classical PMNs, polymorphonuclear myeloid-deri...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 218; no. 4
Main Authors:	Veglia, Filippo, Hashimoto, Ayumi, Dweep, Harsh, Sanseviero, Emilio, De Leo, Alessandra, Tcyganov, Evgenii, Kossenkov, Andrew, Mulligan, Charles, Nam, Brian, Masters, Gregory, Patel, Jaymala, Bhargava, Vipul, Wilkinson, Patrick, Smirnov, Denis, Sepulveda, Manuel A, Singhal, Sunil, Eruslanov, Evgeniy B, Cristescu, Razvan, Loboda, Andrey, Nefedova, Yulia, Gabrilovich, Dmitry I
Format:	Journal Article
Language:	English
Published:	United States 05.04.2021
Subjects:	Animals Carcinoma, Lewis Lung - immunology Carcinoma, Lewis Lung - pathology Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - immunology Case-Control Studies Cell Line, Tumor Disease Models, Animal Female Humans Lung Neoplasms - blood Lung Neoplasms - immunology Lymphoma - immunology Lymphoma - pathology Mice Mice, Inbred C57BL Neutrophils - classification Neutrophils - immunology RNA-Seq Single-Cell Analysis Transcriptome
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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