Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of patients at the extremes of the disease severity spectrum. Here, we performed multi-omic single-cell immune profiling o...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 218; H. 8
Hauptverfasser:	Wilk, Aaron J, Lee, Madeline J, Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J, Ranganath, Thanmayi, Zhao, Nancy Q, Taylor, Shalina, Becker, Winston, Jimenez-Morales, David, Blomkalns, Andra L, O'Hara, Ruth, Ashley, Euan A, Nadeau, Kari C, Yang, Samuel, Holmes, Susan, Rabinovitch, Marlene, Rogers, Angela J, Greenleaf, William J, Blish, Catherine A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.08.2021
Schlagworte:	Adult Aged Case-Control Studies COVID-19 - blood COVID-19 - genetics COVID-19 - immunology COVID-19 - mortality Cytokines - genetics Epigenesis, Genetic Female Hematopoiesis Humans Immunity, Innate - physiology Killer Cells, Natural - pathology Killer Cells, Natural - virology Male Middle Aged Monocytes - pathology Monocytes - virology Neutrophils - pathology Neutrophils - virology NF-kappa B - metabolism Proteomics Severity of Illness Index Single-Cell Analysis
ISSN:	1540-9538, 1540-9538
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