Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites correlates with favorable outcomes. However, metabolic constraints imposed by the tumor microenvironment (TME) can dampen their ability to control tumor progression. We describe lipid accumulation in the TME a...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 217; H. 8
Hauptverfasser:	Manzo, Teresa, Prentice, Boone M, Anderson, Kristin G, Raman, Ayush, Schalck, Aislyn, Codreanu, Gabriela S, Nava Lauson, Carina B, Tiberti, Silvia, Raimondi, Andrea, Jones, Marissa A, Reyzer, Michelle, Bates, Breanna M, Spraggins, Jeffrey M, Patterson, Nathan H, McLean, John A, Rai, Kunal, Tacchetti, Carlo, Tucci, Sara, Wargo, Jennifer A, Rodighiero, Simona, Clise-Dwyer, Karen, Sherrod, Stacy D, Kim, Michael, Navin, Nicholas E, Caprioli, Richard M, Greenberg, Philip D, Draetta, Giulio, Nezi, Luigi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.08.2020
Schlagworte:	Acyl-CoA Dehydrogenase, Long-Chain - biosynthesis Acyl-CoA Dehydrogenase, Long-Chain - genetics Animals Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Down-Regulation Fatty Acids - genetics Fatty Acids - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Lymphocytes, Tumor-Infiltrating - metabolism Lymphocytes, Tumor-Infiltrating - pathology Mice Mice, Mutant Strains Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Pancreas - metabolism Pancreas - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Tumor Microenvironment
ISSN:	1540-9538, 1540-9538
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