Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions

Transcription factors ThPOK and Runx3 regulate the differentiation of "helper" CD4+ and "cytotoxic" CD8+ T cell lineages respectively, inducing single positive (SP) T cells that enter the periphery with the expression of either the CD4 or CD8 co-receptor. Despite the expectation...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of experimental medicine Jg. 219; H. 6
Hauptverfasser:	Schad, Sara E, Chow, Andrew, Mangarin, Levi, Pan, Heng, Zhang, Jiajia, Ceglia, Nicholas, Caushi, Justina X, Malandro, Nicole, Zappasodi, Roberta, Gigoux, Mathieu, Hirschhorn, Daniel, Budhu, Sadna, Amisaki, Masataka, Arniella, Monica, Redmond, David, Chaft, Jamie, Forde, Patrick M, Gainor, Justin F, Hellmann, Matthew D, Balachandran, Vinod, Shah, Sohrab, Smith, Kellie N, Pardoll, Drew, Elemento, Olivier, Wolchok, Jedd D, Merghoub, Taha
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.06.2022
Schlagworte:	Animals CD4 Antigens - metabolism CD4-Positive T-Lymphocytes CD8 Antigens - metabolism CD8-Positive T-Lymphocytes Cell Differentiation Cell Lineage - genetics Melanoma - metabolism Mice T-Lymphocyte Subsets
ISSN:	1540-9538, 1540-9538
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!