An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis

In established multiple sclerosis, tissue abnormality-as assessed using magnetization transfer ratio-increases close to the lateral ventricles. We aimed to determine whether or not (i) these changes are present from the earliest clinical stages of multiple sclerosis; (ii) they occur independent of w...

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Bibliographic Details
Published in:	Brain (London, England : 1878) Vol. 140; no. 2; pp. 387 - 398
Main Authors:	Brown, J William L, Pardini, Matteo, Brownlee, Wallace J, Fernando, Kryshani, Samson, Rebecca S, Prados Carrasco, Ferran, Ourselin, Sebastien, Gandini Wheeler-Kingshott, Claudia A M, Miller, David H, Chard, Declan T
Format:	Journal Article
Language:	English
Published:	England 01.02.2017
Subjects:	Adult Atrophy Cerebral Ventricles - diagnostic imaging Cohort Studies Disability Evaluation Disease Progression Female Humans Image Processing, Computer-Assisted Logistic Models Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis - complications Multiple Sclerosis - diagnostic imaging Optic Neuritis - diagnostic imaging Optic Neuritis - etiology Protons White Matter - pathology Young Adult normal-appearing white matter multiple sclerosis magnetization transfer ratio
ISSN:	1460-2156
Online Access:	Get more information
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