An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis

Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, th...

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Bibliographic Details
Published in:	Biomaterials Vol. 322; p. 123380
Main Authors:	Hu, Ben, Lin, Huimin, Quan, Xiaolong, Sun, Fushan, Zhang, Fengling, Zhang, Fang, Wang, Yu, Chang, Yunhua, Wang, Jigang, Duan, Xiaohui, Yu, Meng
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.11.2025
Subjects:	Animals Blood Platelets - drug effects Blood Platelets - pathology Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Drug delivery Female Glucose oxidase Humans Mice Mice, Inbred BALB C Mice, Nude Nanomedicine Neoplasm Metastasis Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Platelet inhibition Tumor metastasis Glucose oxidase Drug delivery Platelet inhibition Nanomedicine Tumor metastasis
ISSN:	0142-9612, 1878-5905, 1878-5905
Online Access:	Get full text
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