An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis
Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, th...
Gespeichert in:
| Veröffentlicht in: | Biomaterials Jg. 322; S. 123380 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Netherlands
Elsevier Ltd
01.11.2025
|
| Schlagworte: | |
| ISSN: | 0142-9612, 1878-5905, 1878-5905 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, thereby promoting hematogenous tumor metastasis. Based on this, we designed a self-assembling nanoenzyme drug GSNO@B (NO donor-modified GOx self-assembled with the hydrophobic drug BMS-202) against platelet-mediated tumor metastasis. This strategy involves the depletion of glucose by GOx, which inhibits platelets activity and reduces forming the micro-aggregation. Concurrently, the nanoenzyme in situ releases NO further diminishes the protective adhesion and micro-aggregation of platelet on the tumor cells surface, thereby exposing them in shear forces and immune recognition in the circulatory system. Concurrently, the disintegration of the nanoenzyme GSNO@B releases the immune checkpoint inhibitor BMS-202, further facilitating the immune clearance of CTCs. Therefore, through a three-step strategy, GSNO@B effectively suppresses primary tumors growth and metastatic tumors formation by blocking the platelet-mediated hematogenous tumor metastasis pathway. |
|---|---|
| AbstractList | Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, thereby promoting hematogenous tumor metastasis. Based on this, we designed a self-assembling nanoenzyme drug GSNO@B (NO donor-modified GOx self-assembled with the hydrophobic drug BMS-202) against platelet-mediated tumor metastasis. This strategy involves the depletion of glucose by GOx, which inhibits platelets activity and reduces forming the micro-aggregation. Concurrently, the nanoenzyme in situ releases NO further diminishes the protective adhesion and micro-aggregation of platelet on the tumor cells surface, thereby exposing them in shear forces and immune recognition in the circulatory system. Concurrently, the disintegration of the nanoenzyme GSNO@B releases the immune checkpoint inhibitor BMS-202, further facilitating the immune clearance of CTCs. Therefore, through a three-step strategy, GSNO@B effectively suppresses primary tumors growth and metastatic tumors formation by blocking the platelet-mediated hematogenous tumor metastasis pathway. Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, thereby promoting hematogenous tumor metastasis. Based on this, we designed a self-assembling nanoenzyme drug GSNO@B (NO donor-modified GOx self-assembled with the hydrophobic drug BMS-202) against platelet-mediated tumor metastasis. This strategy involves the depletion of glucose by GOx, which inhibits platelets activity and reduces forming the micro-aggregation. Concurrently, the nanoenzyme in situ releases NO further diminishes the protective adhesion and micro-aggregation of platelet on the tumor cells surface, thereby exposing them in shear forces and immune recognition in the circulatory system. Concurrently, the disintegration of the nanoenzyme GSNO@B releases the immune checkpoint inhibitor BMS-202, further facilitating the immune clearance of CTCs. Therefore, through a three-step strategy, GSNO@B effectively suppresses primary tumors growth and metastatic tumors formation by blocking the platelet-mediated hematogenous tumor metastasis pathway.Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, thereby promoting hematogenous tumor metastasis. Based on this, we designed a self-assembling nanoenzyme drug GSNO@B (NO donor-modified GOx self-assembled with the hydrophobic drug BMS-202) against platelet-mediated tumor metastasis. This strategy involves the depletion of glucose by GOx, which inhibits platelets activity and reduces forming the micro-aggregation. Concurrently, the nanoenzyme in situ releases NO further diminishes the protective adhesion and micro-aggregation of platelet on the tumor cells surface, thereby exposing them in shear forces and immune recognition in the circulatory system. Concurrently, the disintegration of the nanoenzyme GSNO@B releases the immune checkpoint inhibitor BMS-202, further facilitating the immune clearance of CTCs. Therefore, through a three-step strategy, GSNO@B effectively suppresses primary tumors growth and metastatic tumors formation by blocking the platelet-mediated hematogenous tumor metastasis pathway. |
| ArticleNumber | 123380 |
| Author | Sun, Fushan Duan, Xiaohui Zhang, Fang Wang, Yu Chang, Yunhua Hu, Ben Quan, Xiaolong Lin, Huimin Zhang, Fengling Wang, Jigang Yu, Meng |
| Author_xml | – sequence: 1 givenname: Ben surname: Hu fullname: Hu, Ben organization: NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China – sequence: 2 givenname: Huimin surname: Lin fullname: Lin, Huimin organization: NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China – sequence: 3 givenname: Xiaolong surname: Quan fullname: Quan, Xiaolong organization: NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China – sequence: 4 givenname: Fushan surname: Sun fullname: Sun, Fushan organization: NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China – sequence: 5 givenname: Fengling surname: Zhang fullname: Zhang, Fengling organization: NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China – sequence: 6 givenname: Fang surname: Zhang fullname: Zhang, Fang organization: Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China – sequence: 7 givenname: Yu surname: Wang fullname: Wang, Yu organization: Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China – sequence: 8 givenname: Yunhua surname: Chang fullname: Chang, Yunhua organization: Université Paris Cité, INSERM, CNRS, Institut Necker Enfants Malades F-75015, Paris, 75005, France – sequence: 9 givenname: Jigang surname: Wang fullname: Wang, Jigang email: jgwang@icmm.ac.cn organization: Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineer Technology Research and Development Center, and Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People's Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, 518020, China – sequence: 10 givenname: Xiaohui orcidid: 0000-0002-2224-0887 surname: Duan fullname: Duan, Xiaohui email: duanxh5@mail.sysu.edu.cn organization: Guangdong Provincial Key Laboratory of Malignant Tumour Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China – sequence: 11 givenname: Meng orcidid: 0000-0003-1039-9687 surname: Yu fullname: Yu, Meng email: yumeng999@smu.edu.cn organization: NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40318603$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUctuFDEQtFAisln4BTTixGWWtj1PbiHhESkSFzhbfvQEbzz2xPYgLV8fRxsQ4pRTd6urS9VV5-TEB4-EvKWwo0C79_udsmGWGaOVLu0YsHZHGecDvCAbOvRD3Y7QnpAN0IbVY0fZGTlPaQ9lhoa9JGcNcDp0wDfEXfhKxmwnqwtZjf73YcYa71e7LGgqO8-rDxFvVydziJVyQd-laikTOsz1jMaW1lQqoky50tJrjNVPLPLCLfqwpmrGXFYy2fSKnE5FMb5-qlvy4_On75df65tvX64vL25qzYcm1wq06Xqm2chhNApMT2WnWmj0oLQaWQcUjBxQThRNJ7lE2U49R9ajglEpviXvjrxLDPcrpixmmzQ6Jz0WRYIzAM7asXi2JW-eoKsqz4gl2lnGg_jjUAF8OAJ0DClFnP5CKIjHOMRe_BuHeIxDHOMox1fHYyzf_rIYRdIWi0XGRtRZmGCfR_PxPxrtrLdaujs8PJfkATHvs-w |
| Cites_doi | 10.1038/288373a0 10.1124/pr.108.000547 10.3390/bioengineering7010009 10.1200/jco.2013.31.15_suppl.1056 10.1016/j.jconrel.2018.02.011 10.1038/279799a0 10.1038/s41420-023-01652-2 10.1021/acsnano.9b09713 10.1126/scitranslmed.aay4860 10.1182/blood-2018-99-116530 10.1016/j.biomaterials.2020.120456 10.1002/advs.201701043 10.1016/j.biomaterials.2017.06.021 10.1158/0008-5472.CAN-21-1180 10.1002/adma.202204733 10.7326/0003-4819-120-3-199402010-00009 10.1021/acs.nanolett.3c00365 10.1038/ncb3478 10.1073/pnas.87.2.682 10.1002/adfm.202204271 10.1016/j.jconrel.2020.01.038 10.1182/blood.V104.11.3884.3884 10.1038/nrc3004 10.1172/JCI94494 10.1182/blood-2016-01-636399 10.1634/stemcells.2007-1076 10.1038/s41586-019-1526-3 10.1038/msb.2012.20 10.1200/JCO.2021.39.15_suppl.e16028 10.18632/oncotarget.8730 10.1002/adma.202209765 10.1186/s12943-019-1102-3 10.1038/s41467-018-07197-8 10.1016/j.cclet.2022.107801 10.1016/j.ultsonch.2016.12.033 10.1186/s12943-021-01347-1 10.1161/CIRCRESAHA.122.321861 10.3390/pharmaceutics13030406 10.1182/blood.2020007140 10.1186/s13045-018-0669-2 10.1182/blood.V128.22.3723.3723 10.1016/j.tracli.2020.07.002 10.3390/cancers15041282 10.1016/j.mattod.2024.01.011 10.1136/jitc-2019-000415 10.1021/acsami.2c15882 10.1038/s41467-021-27017-w 10.1182/blood-2018-99-117070 10.1039/D1NR07233A 10.1208/s12248-016-9995-x 10.1016/j.jconrel.2019.08.016 10.1002/smll.202304058 10.1021/acsnano.1c06022 10.1016/j.biomaterials.2021.120711 10.1093/annonc/mdz268.097 10.1021/acsnano.0c00910 10.1093/annonc/mdz268.043 10.1182/blood.V130.Suppl_1.SCI-26.SCI-26 |
| ContentType | Journal Article |
| Copyright | 2025 Elsevier Ltd Copyright © 2025 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2025 Elsevier Ltd – notice: Copyright © 2025 Elsevier Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.biomaterials.2025.123380 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Engineering |
| EISSN | 1878-5905 |
| ExternalDocumentID | 40318603 10_1016_j_biomaterials_2025_123380 S0142961225002996 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM 9JN AABNK AABXZ AAEDT AAEDW AAEPC AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABFNM ABGSF ABJNI ABMAC ABNUV ABUDA ABWVN ABXDB ABXRA ACDAQ ACGFS ACIUM ACLOT ACNNM ACRLP ACRPL ACVFH ADBBV ADCNI ADEWK ADEZE ADMUD ADNMO ADTZH ADUVX AEBSH AECPX AEHWI AEIPS AEKER AENEX AEUPX AEVXI AEZYN AFFNX AFJKZ AFPUW AFRHN AFRZQ AFTJW AFXIZ AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AHJVU AHPOS AI. AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKURH AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP ASPBG AVWKF AXJTR AZFZN BJAXD BKOJK BLXMC CS3 DU5 EBS EFJIC EFKBS EFLBG EJD ENUVR EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMK HMO HVGLF HZ~ IHE J1W JJJVA KOM M24 M41 MAGPM MO0 N9A O-L O9- OAUVE OB- OM. OZT P-8 P-9 P2P PC. Q38 R2- RNS ROL RPZ SAE SCC SDF SDG SDP SES SEW SMS SPC SPCBC SSG SSM SST SSU SSZ T5K TN5 VH1 WH7 WUQ XPP XUV Z5R ZMT ~G- ~HD AAYOK AFCTW AGCQF AGRNS BNPGV RIG SSH 9DU AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c384t-b0cd672c29309db0d71a6b504c8bcb926010da8eaf1ed6a3aea5f73e27eb09bb3 |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001487265800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0142-9612 1878-5905 |
| IngestDate | Fri Oct 03 00:08:21 EDT 2025 Mon Jul 21 06:03:03 EDT 2025 Sat Nov 29 06:59:36 EST 2025 Sat Jul 05 17:10:32 EDT 2025 Tue Oct 14 19:31:04 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Glucose oxidase Drug delivery Platelet inhibition Nanomedicine Tumor metastasis |
| Language | English |
| License | Copyright © 2025 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c384t-b0cd672c29309db0d71a6b504c8bcb926010da8eaf1ed6a3aea5f73e27eb09bb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0002-2224-0887 0000-0003-1039-9687 |
| PMID | 40318603 |
| PQID | 3200325923 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3200325923 pubmed_primary_40318603 crossref_primary_10_1016_j_biomaterials_2025_123380 elsevier_sciencedirect_doi_10_1016_j_biomaterials_2025_123380 elsevier_clinicalkey_doi_10_1016_j_biomaterials_2025_123380 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-11-01 |
| PublicationDateYYYYMMDD | 2025-11-01 |
| PublicationDate_xml | – month: 11 year: 2025 text: 2025-11-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biomaterials |
| PublicationTitleAlternate | Biomaterials |
| PublicationYear | 2025 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Aboursheid, Albaroudi, Alahdab (bib11) 2022; 7 Yamashita, Tokunaga, Kitao, Tanaka, Taketani, Saeki, Aishima, Oki, Morita, Maehara (bib66) 2013; 31 Chauhan, Thomas, Goodall, Wright, Adlam (bib40) 2019; 30 Zhang, Ma, Luo (bib2) 2021; 13 Ma, Bussonniere, Liu (bib21) 2017; 36 Kong, Wang, Sarkar, Li, Banerjee, Saliganan, Kim, Cher, Sarkar (bib6) 2008; 26 Toda, Ayajiki, Okamura (bib56) 2009; 61 Guo, Deng, Li, He, He, Liu, Ye, Mo, He, Li, He (bib62) 2023; 23 Kinoshita, Ishima, Chuang, Nakamura, Fang, Watanabe, Shimizu, Okuhira, Ishida, Maeda, Otagiri, Maruyama (bib26) 2017; 140 Yang, Zelikin, Chandrawati (bib55) 2018; 5 Schlesinger (bib29) 2018; 11 Duan, Jin, Zhang, Sun, Deng, Gao (bib34) 2023; 35 Battinelli, Johnson, Forward, Tippy, Kulenthirarajan, Mayer, Italiano (bib31) 2016; 128 Zhu, Cai, Xu, Wang, Song, Li, Shen, Dong (bib61) 2023; 19 Grodzinski (bib51) 2019; 309 Padmanaban, Krol, Suhail, Szczerba, Aceto, Bader, Ewald (bib63) 2019; 573 Zak, Grudnik, Guzik, Zieba, Musielak, Dömling, Dubin, Holak (bib49) 2016; 7 Tang, Xie, Li, Mei, Cao, Xiao, Dong, Zhang, Wang (bib57) 2023; 34 Wang, Wang, Wu, Zhou, Qin, Wang, Wu, Sun, Yang, Xu, Qian, Pang, Li, Zhang, Han, Zhang (bib10) 2021; 12 Sengupta, Mahalakshmi, Stebin, Ganesh, Suganya, Chatterjee (bib36) 2020; 27 Chen, Lin, Mai, Tang, Zhang, Chen, Li, Zhang, Wang, Yang, Yu (bib23) 2024; 18 Tang, Cao, Yin, Liu, Feng, Fu, Zhao, Wang (bib58) 2024; 73 Sun, Zhou, Gao (bib52) 2020; 14 Yang, Chen, Li, Liang, Lin, Jakfar, Thacker, Wu, Lin (bib1) 2021; 6 Gay, Felding-Habermann (bib5) 2011; 11 Ma, Li, Zhang, Liang, Liang, Chen, Wang, Li, Zeng, Shan, Niu (bib46) 2021; 11 Jia, Gao, Zhou, Zhao, Hu, Chen, Qiao (bib48) 2021; 271 Henderson, Shankar (bib50) 2016; 19 Li, Li, Lin, Chen, Luo, Huang (bib30) 2021; 16 Labernadie, Kato, Brugués, Serra-Picamal, Derzsi, Arwert, Weston, González-Tarragó, Elosegui-Artola, Albertazzi, Alcaraz, Roca-Cusachs, Sahai, Trepat (bib64) 2017; 19 Dai, Fan, Wang (bib54) 2022; 2 Dudiki, Veleeparambil, Zhevlakova, Biswas, Klein, Ford, Podrez, Byzova (bib60) 2023; 132 Metelli, Wu, Riesenberg, Guglietta, Huck, Mills, Li, Rachidi, Krieg, Rubinstein, Gewirth, Sun, Lilly, Wahlquist, Carbone, Yang, Liu, Li (bib7) 2020; 12 Ulianova, Sagakyants, Novikova, Nepomnyashchaya, Chernikova, Bakulina, Pushkareva, Dzhenkova, Shaposhnikov, Kolesnikov (bib65) 2021; 39 Zhang, Jiang, Lin, Huang (bib27) 2022; 61 Chauhan, Thomas, Goodall, Wright, Adlam (bib43) 2019; 30 Wu, Michelson, Frelinger (bib41) 2018; 132 Yu, Deng, Jia, Wang, Jin, Ji (bib12) 2022; 14 Zhang, Yan, Xu, Tian, Hou, Luo, Sun, Xu, Yu, Wang, Liu (bib37) 2023; 454 Nayak, Ghatge, Flora, Dhanesha, Jain, Markan, Potthoff, Lentz, Chauhan (bib32) 2021; 137 Leblanc, Peyruchaud (bib9) 2016; 128 Yang, Liu, Ma, Xu, Chen, Wang, Xiao, Li, Liang, Yu, Yu (bib24) 2021; 265 Ying, Zhang, Gao, Cai, Wang, Wu, Chen, Meng, Zheng, Hu, Lin (bib39) 2020; 14 Ahmed, Chard, Yuan, Wang, Howells, Li, Li, Zhang, Lu, Gao, Wang, Chu, Al Yaghchi, Schwartz, Alusi, Lemoine, Wang (bib3) 2020; 8 Feng, Li, Yang, Zhang, Hao, Zhang, Hou, Zhang (bib22) 2018; 275 Graham, Tahmasian, Kohli, Komisopoulou, Zhu, Vivanco, Teitell, Wu, Ribas, Lo, Mellinghoff, Mischel, Graeber (bib19) 2012; 8 Yu, Liang, Li, Wang, Liang, Chen, Ma, Wu, Jiao, Niu (bib47) 2023; 9 Ward, Kane, Norris, Mohamed, Kelly, Bates, Clarke, Brady, Martin, Brooks, Brooks, Selemidis, Hanniffy, Dixon, O'Toole, O'Leary (bib59) 2021; 20 Su, Sun, Lin, Lu, Zhang, Li, Li, Sun, Liu, Zhang, Wang, Li, Wei (bib53) 2022; 32 Bredt, Snyder (bib15) 1990; 87 Lee, Bergmeier (bib17) 2017; 127 Chen, Hou, Wang, Tan, Tan, Mao, Yang, Li, Li (bib38) 2022; 14 Li, Liu, Su, Pan, Han, Shao, Shi (bib8) 2019; 18 Li, Sudic, Forslund, Razmara (bib35) 2004; 104 Lowenstein (bib14) 1994; 120 Wu, Ye, Xie, Li, Sun, Lv, Yang, Cui, Chen, Jensen, Cui, Huang, Zuo, Zhang, Liu, Yang (bib16) 2021; 81 Battinelli (bib18) 2017; 130 Oncul, Cho (bib44) 2023; 15 Zhang, Hong, Liu, Yu, Zhang, Zhang, Zeng, Zhang (bib25) 2020; 320 Chignard, Le Couedic, Tence, Vargaftig, Benveniste (bib45) 1979; 279 Yu, Zhou, Pan, Li, Tang (bib20) 2018; 9 Hopkins, Frost (bib28) 2020; 7 Cho, Gonzalez-Pagan, Court Pinto, Sood, Afshar-Kharghan (bib42) 2018; 132 Jiang, Mu, Qiu, Li, Xu, Yu, Fu, Cao, Wang (bib4) 2021; 12 Furchgott, Zawadzki (bib13) 1980; 288 Xu, Liu, Zeng, Ma, Zhang, Yang, Liu, Fang, Zhao, Xu, Ashby, He, Dai, Pan (bib33) 2022; 34 Tang (10.1016/j.biomaterials.2025.123380_bib58) 2024; 73 Xu (10.1016/j.biomaterials.2025.123380_bib33) 2022; 34 Zhang (10.1016/j.biomaterials.2025.123380_bib37) 2023; 454 Yu (10.1016/j.biomaterials.2025.123380_bib47) 2023; 9 Zak (10.1016/j.biomaterials.2025.123380_bib49) 2016; 7 Yu (10.1016/j.biomaterials.2025.123380_bib12) 2022; 14 Jiang (10.1016/j.biomaterials.2025.123380_bib4) 2021; 12 Schlesinger (10.1016/j.biomaterials.2025.123380_bib29) 2018; 11 Zhu (10.1016/j.biomaterials.2025.123380_bib61) 2023; 19 Labernadie (10.1016/j.biomaterials.2025.123380_bib64) 2017; 19 Ulianova (10.1016/j.biomaterials.2025.123380_bib65) 2021; 39 Chen (10.1016/j.biomaterials.2025.123380_bib23) 2024; 18 Padmanaban (10.1016/j.biomaterials.2025.123380_bib63) 2019; 573 Jia (10.1016/j.biomaterials.2025.123380_bib48) 2021; 271 Ma (10.1016/j.biomaterials.2025.123380_bib46) 2021; 11 Guo (10.1016/j.biomaterials.2025.123380_bib62) 2023; 23 Zhang (10.1016/j.biomaterials.2025.123380_bib2) 2021; 13 Chen (10.1016/j.biomaterials.2025.123380_bib38) 2022; 14 Ward (10.1016/j.biomaterials.2025.123380_bib59) 2021; 20 Wu (10.1016/j.biomaterials.2025.123380_bib16) 2021; 81 Sengupta (10.1016/j.biomaterials.2025.123380_bib36) 2020; 27 Grodzinski (10.1016/j.biomaterials.2025.123380_bib51) 2019; 309 Nayak (10.1016/j.biomaterials.2025.123380_bib32) 2021; 137 Kinoshita (10.1016/j.biomaterials.2025.123380_bib26) 2017; 140 Dai (10.1016/j.biomaterials.2025.123380_bib54) 2022; 2 Battinelli (10.1016/j.biomaterials.2025.123380_bib31) 2016; 128 Yang (10.1016/j.biomaterials.2025.123380_bib1) 2021; 6 Duan (10.1016/j.biomaterials.2025.123380_bib34) 2023; 35 Sun (10.1016/j.biomaterials.2025.123380_bib52) 2020; 14 Feng (10.1016/j.biomaterials.2025.123380_bib22) 2018; 275 Zhang (10.1016/j.biomaterials.2025.123380_bib25) 2020; 320 Dudiki (10.1016/j.biomaterials.2025.123380_bib60) 2023; 132 Cho (10.1016/j.biomaterials.2025.123380_bib42) 2018; 132 Toda (10.1016/j.biomaterials.2025.123380_bib56) 2009; 61 Metelli (10.1016/j.biomaterials.2025.123380_bib7) 2020; 12 Chauhan (10.1016/j.biomaterials.2025.123380_bib40) 2019; 30 Henderson (10.1016/j.biomaterials.2025.123380_bib50) 2016; 19 Graham (10.1016/j.biomaterials.2025.123380_bib19) 2012; 8 Oncul (10.1016/j.biomaterials.2025.123380_bib44) 2023; 15 Tang (10.1016/j.biomaterials.2025.123380_bib57) 2023; 34 Li (10.1016/j.biomaterials.2025.123380_bib30) 2021; 16 Su (10.1016/j.biomaterials.2025.123380_bib53) 2022; 32 Hopkins (10.1016/j.biomaterials.2025.123380_bib28) 2020; 7 Chignard (10.1016/j.biomaterials.2025.123380_bib45) 1979; 279 Yang (10.1016/j.biomaterials.2025.123380_bib24) 2021; 265 Kong (10.1016/j.biomaterials.2025.123380_bib6) 2008; 26 Wang (10.1016/j.biomaterials.2025.123380_bib10) 2021; 12 Wu (10.1016/j.biomaterials.2025.123380_bib41) 2018; 132 Chauhan (10.1016/j.biomaterials.2025.123380_bib43) 2019; 30 Lee (10.1016/j.biomaterials.2025.123380_bib17) 2017; 127 Ying (10.1016/j.biomaterials.2025.123380_bib39) 2020; 14 Li (10.1016/j.biomaterials.2025.123380_bib8) 2019; 18 Ma (10.1016/j.biomaterials.2025.123380_bib21) 2017; 36 Aboursheid (10.1016/j.biomaterials.2025.123380_bib11) 2022; 7 Li (10.1016/j.biomaterials.2025.123380_bib35) 2004; 104 Lowenstein (10.1016/j.biomaterials.2025.123380_bib14) 1994; 120 Bredt (10.1016/j.biomaterials.2025.123380_bib15) 1990; 87 Yu (10.1016/j.biomaterials.2025.123380_bib20) 2018; 9 Yang (10.1016/j.biomaterials.2025.123380_bib55) 2018; 5 Ahmed (10.1016/j.biomaterials.2025.123380_bib3) 2020; 8 Gay (10.1016/j.biomaterials.2025.123380_bib5) 2011; 11 Battinelli (10.1016/j.biomaterials.2025.123380_bib18) 2017; 130 Zhang (10.1016/j.biomaterials.2025.123380_bib27) 2022; 61 Leblanc (10.1016/j.biomaterials.2025.123380_bib9) 2016; 128 Furchgott (10.1016/j.biomaterials.2025.123380_bib13) 1980; 288 Yamashita (10.1016/j.biomaterials.2025.123380_bib66) 2013; 31 |
| References_xml | – volume: 454 year: 2023 ident: bib37 article-title: Engineering biomimetic ATP-responsive Se-containing core-shell cascade nanozyme for efficient tumor combination therapy publication-title: Chem. Eng. J. – volume: 34 year: 2022 ident: bib33 article-title: An enzyme‐engineered nonporous Copper(I) coordination polymer nanoplatform for Cuproptosis‐Based synergistic cancer therapy publication-title: Adv. Mater. – volume: 11 start-page: 123 year: 2011 end-page: 134 ident: bib5 article-title: Contribution of platelets to tumour metastasis publication-title: Nat. Rev. Cancer – volume: 14 start-page: 12281 year: 2020 end-page: 12290 ident: bib52 article-title: What went wrong with anticancer nanomedicine design and how to make it right publication-title: ACS Nano – volume: 19 start-page: 343 year: 2016 end-page: 359 ident: bib50 article-title: Clinical translation of the national Institutes of health's investments in nanodrug products and devices publication-title: AAPS J. – volume: 573 start-page: 439 year: 2019 end-page: 444 ident: bib63 article-title: E-cadherin is required for metastasis in multiple models of breast cancer publication-title: Nature – volume: 12 year: 2021 ident: bib10 article-title: The essential role of PRAK in tumor metastasis and its therapeutic potential publication-title: Nat. Commun. – volume: 5 year: 2018 ident: bib55 article-title: Progress and promise of nitric oxide‐releasing platforms publication-title: Adv. Sci. – volume: 73 start-page: 79 year: 2024 end-page: 95 ident: bib58 article-title: Dual-targeting nanozyme combined with aPD-L1-based immunotherapy for combating cancer recurrence and metastasis publication-title: Mater. Today – volume: 265 year: 2021 ident: bib24 article-title: Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy publication-title: Biomaterials – volume: 275 start-page: 192 year: 2018 end-page: 200 ident: bib22 article-title: Hypoxia-specific therapeutic agents delivery nanotheranostics: a sequential strategy for ultrasound mediated on-demand tritherapies and imaging of cancer publication-title: J. Contr. Release – volume: 20 year: 2021 ident: bib59 article-title: Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell? publication-title: Mol. Cancer – volume: 23 start-page: 3401 year: 2023 end-page: 3411 ident: bib62 article-title: Depriving tumor cells of ways to metastasize: ferroptosis nanotherapy blocks both hematogenous metastasis and lymphatic metastasis publication-title: Nano Lett. – volume: 127 start-page: 2040 year: 2017 end-page: 2043 ident: bib17 article-title: Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity publication-title: J. Clin. Investig. – volume: 137 start-page: 1658 year: 2021 end-page: 1668 ident: bib32 article-title: The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis publication-title: Blood – volume: 19 year: 2023 ident: bib61 article-title: Acidity-responsive nanoreactors destructed “WarburgEffect” for toxic-acidosis and starvation synergistic therapy publication-title: Small – volume: 14 start-page: 3808 year: 2022 end-page: 3817 ident: bib38 article-title: ATP-responsive near-infrared fluorescent nanoparticles for synergistic chemotherapy and starvation therapy publication-title: Nanoscale – volume: 7 year: 2020 ident: bib28 article-title: S-Nitroso-N-Acetyl-D-Penicillamine modified hyperbranched polyamidoamine for high-capacity nitric oxide storage and release publication-title: Bioengineering – volume: 8 year: 2020 ident: bib3 article-title: A new oncolyticVacciniavirusaugments antitumor immune responses to prevent tumor recurrence and metastasis after surgery publication-title: J. Immunother. Cancer – volume: 35 year: 2023 ident: bib34 article-title: Thermo‐pH‐Sensitive polymer conjugated glucose oxidase for tumor‐selective starvation‐oxidation‐immune therapy publication-title: Adv. Mater. – volume: 87 start-page: 682 year: 1990 end-page: 685 ident: bib15 article-title: Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 130 year: 2017 ident: bib18 article-title: Platelet and megakaryocytic regulation of tumor progression publication-title: Blood – volume: 288 start-page: 373 year: 1980 end-page: 376 ident: bib13 article-title: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine publication-title: Nature – volume: 13 year: 2021 ident: bib2 article-title: Chondroitin sulfate-modified liposomes for targeted Co-Delivery of doxorubicin and retinoic acid to suppress breast cancer lung metastasis publication-title: Pharmaceutics – volume: 104 start-page: 3884 year: 2004 ident: bib35 article-title: Acute hyperglycaemia enhances platelet activation: involvement of multiple mechanisms publication-title: Blood – volume: 11 year: 2018 ident: bib29 article-title: Role of platelets and platelet receptors in cancer metastasis publication-title: J. Hematol. Oncol. – volume: 279 start-page: 799 year: 1979 end-page: 800 ident: bib45 article-title: The role of platelet-activating factor in platelet aggregation publication-title: Nature – volume: 120 year: 1994 ident: bib14 article-title: Nitric oxide: a physiologic messenger publication-title: Ann. Intern. Med. – volume: 6 start-page: 1699 year: 2021 end-page: 1710 ident: bib1 article-title: The development of laminin-alginate microspheres encapsulated with ginsenoside Rg1 and ADSCs for breast reconstruction after lumpectomy publication-title: Bioact. Mater. – volume: 9 year: 2023 ident: bib47 article-title: Correction: glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment publication-title: Cell Death Discov. – volume: 2 year: 2022 ident: bib54 article-title: Recent applications of immunomodulatory biomaterials for disease immunotherapy publication-title: Explorations – volume: 18 year: 2024 ident: bib23 article-title: Carrier-free photodynamic bioregulators inhibiting lactic acid efflux combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy publication-title: ACS Nano – volume: 27 start-page: 229 year: 2020 end-page: 236 ident: bib36 article-title: Nitric oxide donors offer protection to RBC from storage lesion publication-title: Transfus. Clin. Biol. – volume: 11 year: 2021 ident: bib46 article-title: Targeted glucose or glutamine metabolic therapy combined with PD-1/PD-L1 checkpoint blockade immunotherapy for the treatment of tumors - mechanisms and strategies publication-title: Front. Oncol. – volume: 61 year: 2022 ident: bib27 article-title: Antineoplastic enzyme as drug carrier with activatable catalytic activity for efficient combined therapy publication-title: Angew. Chem. Int. Ed. – volume: 34 year: 2023 ident: bib57 article-title: Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment publication-title: Chin. Chem. Lett. – volume: 61 start-page: 62 year: 2009 end-page: 97 ident: bib56 article-title: Cerebral blood flow regulation by nitric oxide: recent advances publication-title: Pharmacol. Rev. – volume: 19 start-page: 224 year: 2017 end-page: 237 ident: bib64 article-title: A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion publication-title: Nat. Cell Biol. – volume: 39 year: 2021 ident: bib65 article-title: Correlation of E- and N-cadherin expressions as a prognostic factor in metastatic and nonmetastatic gastric tumors publication-title: J. Clin. Oncol. – volume: 8 year: 2012 ident: bib19 article-title: Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death publication-title: Mol. Syst. Biol. – volume: 9 year: 2018 ident: bib20 article-title: A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis publication-title: Nat. Commun. – volume: 132 start-page: 4971 year: 2018 ident: bib41 article-title: Synergistic platelet inhibitory effects of riociguat and nitric oxide are decreased by protein binding publication-title: Blood – volume: 7 start-page: CD011808 year: 2022 ident: bib11 article-title: Inhaled nitric oxide for treating pain crises in people with sickle cell disease publication-title: Cochrane Database Syst. Rev. – volume: 14 start-page: 9662 year: 2020 end-page: 9674 ident: bib39 article-title: Hollow magnetic nanocatalysts drive starvation–chemodynamic–hyperthermia synergistic therapy for tumor publication-title: ACS Nano – volume: 132 start-page: 1447 year: 2023 end-page: 1461 ident: bib60 article-title: Mechanism of tumor-platelet communications in cancer publication-title: Circ. Res. – volume: 309 start-page: 341 year: 2019 end-page: 342 ident: bib51 article-title: NCI centers of cancer nanotechnology excellence (CCNEs) – a full story to set the record straight publication-title: J. Contr. Release – volume: 320 start-page: 159 year: 2020 end-page: 167 ident: bib25 article-title: pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery publication-title: J. Contr. Release – volume: 7 start-page: 30323 year: 2016 end-page: 30335 ident: bib49 article-title: Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1) publication-title: Oncotarget – volume: 140 start-page: 162 year: 2017 end-page: 169 ident: bib26 article-title: Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer publication-title: Biomaterials – volume: 12 year: 2020 ident: bib7 article-title: Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β publication-title: Sci. Transl. Med. – volume: 128 start-page: 24 year: 2016 end-page: 31 ident: bib9 article-title: Metastasis: new functional implications of platelets and megakaryocytes publication-title: Blood – volume: 31 start-page: 1056 year: 2013 ident: bib66 article-title: Significance of the vimentin expression in triple-negative breast cancer publication-title: J. Clin. Oncol. – volume: 18 year: 2019 ident: bib8 article-title: Harnessing tumor-associated macrophages as aids for cancer immunotherapy publication-title: Mol. Cancer – volume: 12 year: 2021 ident: bib4 article-title: Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors publication-title: Nat. Commun. – volume: 81 start-page: 5506 year: 2021 end-page: 5522 ident: bib16 article-title: Megakaryocytes mediate hyperglycemia-induced tumor metastasis publication-title: Cancer Res. – volume: 30 year: 2019 ident: bib40 article-title: Aspirin and ticagrelor for the prevention of tumour cell induced platelet aggregation publication-title: Ann. Oncol. – volume: 26 start-page: 1425 year: 2008 end-page: 1435 ident: bib6 article-title: Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells publication-title: Stem Cell. – volume: 16 start-page: 50 year: 2021 end-page: 67 ident: bib30 article-title: Targeted inhibition of tumor inflammation and tumor-platelet crosstalk by nanoparticle-mediated drug delivery mitigates cancer metastasis publication-title: ACS Nano – volume: 36 start-page: 454 year: 2017 end-page: 465 ident: bib21 article-title: A facile sonochemical synthesis of shell-stabilized reactive microbubbles using surface-thiolated bovine serum albumin with the Traut's reagent publication-title: Ultrason. Sonochem. – volume: 30 year: 2019 ident: bib43 article-title: Platelets from metastatic cancer patients have increased aggregation and activation publication-title: Ann. Oncol. – volume: 271 year: 2021 ident: bib48 article-title: Enhanced response to PD-L1 silencing by modulation of TME via balancing glucose metabolism and robust co-delivery of siRNA/Resveratrol with dual-responsive polyplexes publication-title: Biomaterials – volume: 128 start-page: 3723 year: 2016 ident: bib31 article-title: Tamoxifen directly inhibits platelet activation, angiogenic potential and platelet-mediated metastasis publication-title: Blood – volume: 132 start-page: 3698 year: 2018 ident: bib42 article-title: The inhibition of platelets restore anti-tumor immune response to ovarian cancer and its therapeutic implication publication-title: Blood – volume: 15 year: 2023 ident: bib44 article-title: Interactions between platelets and tumor microenvironment components in ovarian cancer and their implications for treatment and clinical outcomes publication-title: Cancers – volume: 32 year: 2022 ident: bib53 article-title: Biosynthetic and unfolded protein nanocarriers for chemotherapeutic drugs in oral cancers: improved bioavailability and safety of chemotherapeutics publication-title: Adv. Funct. Mater. – volume: 14 start-page: 48515 year: 2022 end-page: 48526 ident: bib12 article-title: A supramolecular nitric oxide nanodelivery system for prevention of tumor metastasis by inhibiting platelet activation and aggregation publication-title: ACS Appl. Mater. Interfaces – volume: 288 start-page: 373 issue: 5789 year: 1980 ident: 10.1016/j.biomaterials.2025.123380_bib13 article-title: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine publication-title: Nature doi: 10.1038/288373a0 – volume: 12 issue: 1 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib10 article-title: The essential role of PRAK in tumor metastasis and its therapeutic potential publication-title: Nat. Commun. – volume: 61 start-page: 62 issue: 1 year: 2009 ident: 10.1016/j.biomaterials.2025.123380_bib56 article-title: Cerebral blood flow regulation by nitric oxide: recent advances publication-title: Pharmacol. Rev. doi: 10.1124/pr.108.000547 – volume: 7 issue: 1 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib28 article-title: S-Nitroso-N-Acetyl-D-Penicillamine modified hyperbranched polyamidoamine for high-capacity nitric oxide storage and release publication-title: Bioengineering doi: 10.3390/bioengineering7010009 – volume: 31 start-page: 1056 issue: 15_suppl year: 2013 ident: 10.1016/j.biomaterials.2025.123380_bib66 article-title: Significance of the vimentin expression in triple-negative breast cancer publication-title: J. Clin. Oncol. doi: 10.1200/jco.2013.31.15_suppl.1056 – volume: 275 start-page: 192 year: 2018 ident: 10.1016/j.biomaterials.2025.123380_bib22 article-title: Hypoxia-specific therapeutic agents delivery nanotheranostics: a sequential strategy for ultrasound mediated on-demand tritherapies and imaging of cancer publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2018.02.011 – volume: 279 start-page: 799 issue: 5716 year: 1979 ident: 10.1016/j.biomaterials.2025.123380_bib45 article-title: The role of platelet-activating factor in platelet aggregation publication-title: Nature doi: 10.1038/279799a0 – volume: 9 issue: 1 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib47 article-title: Correction: glucose metabolism involved in PD-L1-mediated immune escape in the malignant kidney tumour microenvironment publication-title: Cell Death Discov. doi: 10.1038/s41420-023-01652-2 – volume: 14 start-page: 12281 issue: 10 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib52 article-title: What went wrong with anticancer nanomedicine design and how to make it right publication-title: ACS Nano doi: 10.1021/acsnano.9b09713 – volume: 12 issue: 525 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib7 article-title: Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aay4860 – volume: 132 start-page: 3698 issue: Supplement 1 year: 2018 ident: 10.1016/j.biomaterials.2025.123380_bib42 article-title: The inhibition of platelets restore anti-tumor immune response to ovarian cancer and its therapeutic implication publication-title: Blood doi: 10.1182/blood-2018-99-116530 – volume: 18 issue: 30 year: 2024 ident: 10.1016/j.biomaterials.2025.123380_bib23 article-title: Carrier-free photodynamic bioregulators inhibiting lactic acid efflux combined with immune checkpoint blockade for triple-negative breast cancer immunotherapy publication-title: ACS Nano – volume: 265 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib24 article-title: Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2020.120456 – volume: 5 issue: 6 year: 2018 ident: 10.1016/j.biomaterials.2025.123380_bib55 article-title: Progress and promise of nitric oxide‐releasing platforms publication-title: Adv. Sci. doi: 10.1002/advs.201701043 – volume: 140 start-page: 162 year: 2017 ident: 10.1016/j.biomaterials.2025.123380_bib26 article-title: Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer publication-title: Biomaterials doi: 10.1016/j.biomaterials.2017.06.021 – volume: 81 start-page: 5506 issue: 21 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib16 article-title: Megakaryocytes mediate hyperglycemia-induced tumor metastasis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-21-1180 – volume: 454 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib37 article-title: Engineering biomimetic ATP-responsive Se-containing core-shell cascade nanozyme for efficient tumor combination therapy publication-title: Chem. Eng. J. – volume: 34 issue: 43 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib33 article-title: An enzyme‐engineered nonporous Copper(I) coordination polymer nanoplatform for Cuproptosis‐Based synergistic cancer therapy publication-title: Adv. Mater. doi: 10.1002/adma.202204733 – volume: 120 issue: 3 year: 1994 ident: 10.1016/j.biomaterials.2025.123380_bib14 article-title: Nitric oxide: a physiologic messenger publication-title: Ann. Intern. Med. doi: 10.7326/0003-4819-120-3-199402010-00009 – volume: 23 start-page: 3401 issue: 8 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib62 article-title: Depriving tumor cells of ways to metastasize: ferroptosis nanotherapy blocks both hematogenous metastasis and lymphatic metastasis publication-title: Nano Lett. doi: 10.1021/acs.nanolett.3c00365 – volume: 19 start-page: 224 issue: 3 year: 2017 ident: 10.1016/j.biomaterials.2025.123380_bib64 article-title: A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion publication-title: Nat. Cell Biol. doi: 10.1038/ncb3478 – volume: 87 start-page: 682 issue: 2 year: 1990 ident: 10.1016/j.biomaterials.2025.123380_bib15 article-title: Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.87.2.682 – volume: 32 issue: 45 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib53 article-title: Biosynthetic and unfolded protein nanocarriers for chemotherapeutic drugs in oral cancers: improved bioavailability and safety of chemotherapeutics publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.202204271 – volume: 320 start-page: 159 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib25 article-title: pH-sensitive MOF integrated with glucose oxidase for glucose-responsive insulin delivery publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2020.01.038 – volume: 104 start-page: 3884 issue: 11 year: 2004 ident: 10.1016/j.biomaterials.2025.123380_bib35 article-title: Acute hyperglycaemia enhances platelet activation: involvement of multiple mechanisms publication-title: Blood doi: 10.1182/blood.V104.11.3884.3884 – volume: 11 start-page: 123 issue: 2 year: 2011 ident: 10.1016/j.biomaterials.2025.123380_bib5 article-title: Contribution of platelets to tumour metastasis publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3004 – volume: 127 start-page: 2040 issue: 6 year: 2017 ident: 10.1016/j.biomaterials.2025.123380_bib17 article-title: Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity publication-title: J. Clin. Investig. doi: 10.1172/JCI94494 – volume: 128 start-page: 24 issue: 1 year: 2016 ident: 10.1016/j.biomaterials.2025.123380_bib9 article-title: Metastasis: new functional implications of platelets and megakaryocytes publication-title: Blood doi: 10.1182/blood-2016-01-636399 – volume: 26 start-page: 1425 issue: 6 year: 2008 ident: 10.1016/j.biomaterials.2025.123380_bib6 article-title: Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells publication-title: Stem Cell. doi: 10.1634/stemcells.2007-1076 – volume: 573 start-page: 439 issue: 7774 year: 2019 ident: 10.1016/j.biomaterials.2025.123380_bib63 article-title: E-cadherin is required for metastasis in multiple models of breast cancer publication-title: Nature doi: 10.1038/s41586-019-1526-3 – volume: 2 issue: 6 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib54 article-title: Recent applications of immunomodulatory biomaterials for disease immunotherapy publication-title: Explorations – volume: 8 year: 2012 ident: 10.1016/j.biomaterials.2025.123380_bib19 article-title: Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death publication-title: Mol. Syst. Biol. doi: 10.1038/msb.2012.20 – volume: 39 issue: 15_suppl year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib65 article-title: Correlation of E- and N-cadherin expressions as a prognostic factor in metastatic and nonmetastatic gastric tumors publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2021.39.15_suppl.e16028 – volume: 7 start-page: 30323 issue: 21 year: 2016 ident: 10.1016/j.biomaterials.2025.123380_bib49 article-title: Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1) publication-title: Oncotarget doi: 10.18632/oncotarget.8730 – volume: 35 issue: 17 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib34 article-title: Thermo‐pH‐Sensitive polymer conjugated glucose oxidase for tumor‐selective starvation‐oxidation‐immune therapy publication-title: Adv. Mater. doi: 10.1002/adma.202209765 – volume: 18 issue: 1 year: 2019 ident: 10.1016/j.biomaterials.2025.123380_bib8 article-title: Harnessing tumor-associated macrophages as aids for cancer immunotherapy publication-title: Mol. Cancer doi: 10.1186/s12943-019-1102-3 – volume: 9 issue: 1 year: 2018 ident: 10.1016/j.biomaterials.2025.123380_bib20 article-title: A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis publication-title: Nat. Commun. doi: 10.1038/s41467-018-07197-8 – volume: 34 issue: 5 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib57 article-title: Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment publication-title: Chin. Chem. Lett. doi: 10.1016/j.cclet.2022.107801 – volume: 36 start-page: 454 year: 2017 ident: 10.1016/j.biomaterials.2025.123380_bib21 article-title: A facile sonochemical synthesis of shell-stabilized reactive microbubbles using surface-thiolated bovine serum albumin with the Traut's reagent publication-title: Ultrason. Sonochem. doi: 10.1016/j.ultsonch.2016.12.033 – volume: 11 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib46 article-title: Targeted glucose or glutamine metabolic therapy combined with PD-1/PD-L1 checkpoint blockade immunotherapy for the treatment of tumors - mechanisms and strategies publication-title: Front. Oncol. – volume: 20 issue: 1 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib59 article-title: Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell? publication-title: Mol. Cancer doi: 10.1186/s12943-021-01347-1 – volume: 6 start-page: 1699 issue: 6 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib1 article-title: The development of laminin-alginate microspheres encapsulated with ginsenoside Rg1 and ADSCs for breast reconstruction after lumpectomy publication-title: Bioact. Mater. – volume: 132 start-page: 1447 issue: 11 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib60 article-title: Mechanism of tumor-platelet communications in cancer publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.122.321861 – volume: 13 issue: 3 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib2 article-title: Chondroitin sulfate-modified liposomes for targeted Co-Delivery of doxorubicin and retinoic acid to suppress breast cancer lung metastasis publication-title: Pharmaceutics doi: 10.3390/pharmaceutics13030406 – volume: 137 start-page: 1658 issue: 12 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib32 article-title: The metabolic enzyme pyruvate kinase M2 regulates platelet function and arterial thrombosis publication-title: Blood doi: 10.1182/blood.2020007140 – volume: 11 issue: 1 year: 2018 ident: 10.1016/j.biomaterials.2025.123380_bib29 article-title: Role of platelets and platelet receptors in cancer metastasis publication-title: J. Hematol. Oncol. doi: 10.1186/s13045-018-0669-2 – volume: 128 start-page: 3723 issue: 22 year: 2016 ident: 10.1016/j.biomaterials.2025.123380_bib31 article-title: Tamoxifen directly inhibits platelet activation, angiogenic potential and platelet-mediated metastasis publication-title: Blood doi: 10.1182/blood.V128.22.3723.3723 – volume: 27 start-page: 229 issue: 4 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib36 article-title: Nitric oxide donors offer protection to RBC from storage lesion publication-title: Transfus. Clin. Biol. doi: 10.1016/j.tracli.2020.07.002 – volume: 15 issue: 4 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib44 article-title: Interactions between platelets and tumor microenvironment components in ovarian cancer and their implications for treatment and clinical outcomes publication-title: Cancers doi: 10.3390/cancers15041282 – volume: 73 start-page: 79 year: 2024 ident: 10.1016/j.biomaterials.2025.123380_bib58 article-title: Dual-targeting nanozyme combined with aPD-L1-based immunotherapy for combating cancer recurrence and metastasis publication-title: Mater. Today doi: 10.1016/j.mattod.2024.01.011 – volume: 7 start-page: CD011808 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib11 article-title: Inhaled nitric oxide for treating pain crises in people with sickle cell disease publication-title: Cochrane Database Syst. Rev. – volume: 8 issue: 1 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib3 article-title: A new oncolyticVacciniavirusaugments antitumor immune responses to prevent tumor recurrence and metastasis after surgery publication-title: J. Immunother. Cancer doi: 10.1136/jitc-2019-000415 – volume: 14 start-page: 48515 issue: 43 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib12 article-title: A supramolecular nitric oxide nanodelivery system for prevention of tumor metastasis by inhibiting platelet activation and aggregation publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.2c15882 – volume: 12 issue: 1 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib4 article-title: Machine learning of genomic features in organotropic metastases stratifies progression risk of primary tumors publication-title: Nat. Commun. doi: 10.1038/s41467-021-27017-w – volume: 132 start-page: 4971 issue: Supplement 1 year: 2018 ident: 10.1016/j.biomaterials.2025.123380_bib41 article-title: Synergistic platelet inhibitory effects of riociguat and nitric oxide are decreased by protein binding publication-title: Blood doi: 10.1182/blood-2018-99-117070 – volume: 14 start-page: 3808 issue: 10 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib38 article-title: ATP-responsive near-infrared fluorescent nanoparticles for synergistic chemotherapy and starvation therapy publication-title: Nanoscale doi: 10.1039/D1NR07233A – volume: 19 start-page: 343 issue: 2 year: 2016 ident: 10.1016/j.biomaterials.2025.123380_bib50 article-title: Clinical translation of the national Institutes of health's investments in nanodrug products and devices publication-title: AAPS J. doi: 10.1208/s12248-016-9995-x – volume: 309 start-page: 341 year: 2019 ident: 10.1016/j.biomaterials.2025.123380_bib51 article-title: NCI centers of cancer nanotechnology excellence (CCNEs) – a full story to set the record straight publication-title: J. Contr. Release doi: 10.1016/j.jconrel.2019.08.016 – volume: 19 issue: 46 year: 2023 ident: 10.1016/j.biomaterials.2025.123380_bib61 article-title: Acidity-responsive nanoreactors destructed “WarburgEffect” for toxic-acidosis and starvation synergistic therapy publication-title: Small doi: 10.1002/smll.202304058 – volume: 16 start-page: 50 issue: 1 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib30 article-title: Targeted inhibition of tumor inflammation and tumor-platelet crosstalk by nanoparticle-mediated drug delivery mitigates cancer metastasis publication-title: ACS Nano doi: 10.1021/acsnano.1c06022 – volume: 271 year: 2021 ident: 10.1016/j.biomaterials.2025.123380_bib48 article-title: Enhanced response to PD-L1 silencing by modulation of TME via balancing glucose metabolism and robust co-delivery of siRNA/Resveratrol with dual-responsive polyplexes publication-title: Biomaterials doi: 10.1016/j.biomaterials.2021.120711 – volume: 61 issue: 41 year: 2022 ident: 10.1016/j.biomaterials.2025.123380_bib27 article-title: Antineoplastic enzyme as drug carrier with activatable catalytic activity for efficient combined therapy publication-title: Angew. Chem. Int. Ed. – volume: 30 year: 2019 ident: 10.1016/j.biomaterials.2025.123380_bib40 article-title: Aspirin and ticagrelor for the prevention of tumour cell induced platelet aggregation publication-title: Ann. Oncol. doi: 10.1093/annonc/mdz268.097 – volume: 14 start-page: 9662 issue: 8 year: 2020 ident: 10.1016/j.biomaterials.2025.123380_bib39 article-title: Hollow magnetic nanocatalysts drive starvation–chemodynamic–hyperthermia synergistic therapy for tumor publication-title: ACS Nano doi: 10.1021/acsnano.0c00910 – volume: 30 year: 2019 ident: 10.1016/j.biomaterials.2025.123380_bib43 article-title: Platelets from metastatic cancer patients have increased aggregation and activation publication-title: Ann. Oncol. doi: 10.1093/annonc/mdz268.043 – volume: 130 issue: Suppl_1 year: 2017 ident: 10.1016/j.biomaterials.2025.123380_bib18 article-title: Platelet and megakaryocytic regulation of tumor progression publication-title: Blood doi: 10.1182/blood.V130.Suppl_1.SCI-26.SCI-26 |
| SSID | ssj0014042 |
| Score | 2.4987872 |
| Snippet | Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 123380 |
| SubjectTerms | Animals Blood Platelets - drug effects Blood Platelets - pathology Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cell Line, Tumor Drug delivery Female Glucose oxidase Humans Mice Mice, Inbred BALB C Mice, Nude Nanomedicine Neoplasm Metastasis Neoplastic Cells, Circulating - drug effects Neoplastic Cells, Circulating - pathology Platelet inhibition Tumor metastasis |
| Title | An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0142961225002996 https://dx.doi.org/10.1016/j.biomaterials.2025.123380 https://www.ncbi.nlm.nih.gov/pubmed/40318603 https://www.proquest.com/docview/3200325923 |
| Volume | 322 |
| WOSCitedRecordID | wos001487265800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1878-5905 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0014042 issn: 0142-9612 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZYhxA8TDAuKxuTkXhDrlLbuViIh2oaGmhMPAwpb5EduyKDpV2TosGv5zh2km5TpSLES1SldRLn-3rO8fG5IPTGVjCXkgsSJfmUcC4ZSXRoiKScaWYiMeVNovBpfHaWpKn44rNLqqadQFyWyfW1mP9XqOEcgG1TZ_8C7u6icAI-A-hwBNjhuBHwk9IWLipcZQhiyt-_Lg0xV8tiPgfjsrD5ILOF60BvIzVBmX2vbDPpGhQQLIKb1h3WLLXR6rUNCsvN4m1T2nXmC7pemhq-klVR3dgSLmbwGzfDniwNf_p0s1NXsuBkaZuJ9U5X54VNCwmi2KvSZqPK2dbL6pvnsHdP0NDn6XU-szZvpg9Scm5MSkQ0viGHmUtQviPTnXvhYqRWpjGytxqB1mWuD9Stmtk2ZI3a64OBF4DCjbbQNo1DkQzQ9uTjcfqp22jiQdNfqXugti5tEwK47o7rbJh1a5TGVjl_jHb8IgNPHDmeoHum3EWPVkpP7qIHn31QxVP0Y1Li9YzBtxiDHWPwHcZgxxjsGINXGYN7xjxDXz8cnx-dEN-Eg-Qs4TVRQa6jmOZgFgZCq0DHYxmpMOB5onIlbEW6QMvEyOnY6EgyaWQ4jZmhsVGBUIo9R4NyVpo9hKmEoRSMIQmSwO5faxALYahprjUXYzVErH2t2dzVWsnaIMSLbBWMzIKROTCG6F2LQNZmE4P-y4A-G41-3432NqezJTce_7oFPQPBbHfbZGngzWbMhn3SEBZQQ_TCsaGbFbeqNArYy3969n30sP_HHaBBvViaV-h-_rMuqsUh2orT5NDz_Q-QwMjQ |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+artificial-enzyme-equipped+immunoregulator+blocks+platelet-mediated+breast+cancer+hematogenous+metastasis&rft.jtitle=Biomaterials&rft.au=Hu%2C+Ben&rft.au=Lin%2C+Huimin&rft.au=Quan%2C+Xiaolong&rft.au=Sun%2C+Fushan&rft.date=2025-11-01&rft.pub=Elsevier+Ltd&rft.issn=0142-9612&rft.volume=322&rft_id=info:doi/10.1016%2Fj.biomaterials.2025.123380&rft.externalDocID=S0142961225002996 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0142-9612&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0142-9612&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0142-9612&client=summon |