Mild, calcium catalysed Beckmann rearrangements

A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medic...

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Veröffentlicht in:Chemical communications (Cambridge, England) Jg. 54; H. 6; S. 654 - 657
Hauptverfasser: Kiely-Collins, H. J., Sechi, I., Brennan, P. E., McLaughlin, M. G.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: CAMBRIDGE Royal Soc Chemistry 16.01.2018
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ISSN:1359-7345, 1364-548X, 1364-548X
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Abstract A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.
AbstractList A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.
A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.
Author Sechi, I.
McLaughlin, M. G.
Brennan, P. E.
Kiely-Collins, H. J.
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  surname: Brennan
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  givenname: M. G.
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  email: M.mclaughlin@mmu.ac.uk
  organization: Univ Oxford, Struct Genom Consortium, NDM Res Bldg,Roosevelt Dr, Oxford OX3 7FZ, England
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Issue 6
Keywords ENANTIOSELECTIVE 1,4-ADDITION
CYCLOADDITION
OXIMES
PRODUCT
KETOXIMES
LACTAMS
DERIVATIVES
CARBINOLS
CHLORIDE
AMIDES
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Snippet A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the...
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SubjectTerms Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
Title Mild, calcium catalysed Beckmann rearrangements
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https://www.ncbi.nlm.nih.gov/pubmed/29300400
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