Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
Platelet-rich plasma (PRP) is a biologic therapy that promotes healing responses across multiple medical fields, including the central nervous system (CNS). The efficacy of this therapy depends on several factors such as the donor’s health status and age. This work aims to prove the effect of PRP on...
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| Vydané v: | International journal of molecular sciences Ročník 22; číslo 4; s. 1725 |
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| Hlavní autori: | , , , , , , , , , , , , , , , |
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Switzerland
MDPI
09.02.2021
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| ISSN: | 1422-0067, 1422-0067 |
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| Abstract | Platelet-rich plasma (PRP) is a biologic therapy that promotes healing responses across multiple medical fields, including the central nervous system (CNS). The efficacy of this therapy depends on several factors such as the donor’s health status and age. This work aims to prove the effect of PRP on cellular models of the CNS, considering the differences between PRP from young and elderly donors. Two different PRP pools were prepared from donors 65–85 and 20–25 years old. The cellular and molecular composition of both PRPs were analyzed. Subsequently, the cellular response was evaluated in CNS in vitro models, studying proliferation, neurogenesis, synaptogenesis, and inflammation. While no differences in the cellular composition of PRPs were found, the molecular composition of the Young PRP showed lower levels of inflammatory molecules such as CCL-11, as well as the presence of other factors not found in Aged PRP (GDF-11). Although both PRPs had effects in terms of reducing neural progenitor cell apoptosis, stabilizing neuronal synapses, and decreasing inflammation in the microglia, the effect of the Young PRP was more pronounced. In conclusion, the molecular composition of the PRP, conditioned by the age of the donors, affects the magnitude of the biological response. |
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| AbstractList | Platelet-rich plasma (PRP) is a biologic therapy that promotes healing responses across multiple medical fields, including the central nervous system (CNS). The efficacy of this therapy depends on several factors such as the donor’s health status and age. This work aims to prove the effect of PRP on cellular models of the CNS, considering the differences between PRP from young and elderly donors. Two different PRP pools were prepared from donors 65–85 and 20–25 years old. The cellular and molecular composition of both PRPs were analyzed. Subsequently, the cellular response was evaluated in CNS in vitro models, studying proliferation, neurogenesis, synaptogenesis, and inflammation. While no differences in the cellular composition of PRPs were found, the molecular composition of the Young PRP showed lower levels of inflammatory molecules such as CCL-11, as well as the presence of other factors not found in Aged PRP (GDF-11). Although both PRPs had effects in terms of reducing neural progenitor cell apoptosis, stabilizing neuronal synapses, and decreasing inflammation in the microglia, the effect of the Young PRP was more pronounced. In conclusion, the molecular composition of the PRP, conditioned by the age of the donors, affects the magnitude of the biological response. Platelet-rich plasma (PRP) is a biologic therapy that promotes healing responses across multiple medical fields, including the central nervous system (CNS). The efficacy of this therapy depends on several factors such as the donor's health status and age. This work aims to prove the effect of PRP on cellular models of the CNS, considering the differences between PRP from young and elderly donors. Two different PRP pools were prepared from donors 65‒85 and 20‒25 years old. The cellular and molecular composition of both PRPs were analyzed. Subsequently, the cellular response was evaluated in CNS in vitro models, studying proliferation, neurogenesis, synaptogenesis, and inflammation. While no differences in the cellular composition of PRPs were found, the molecular composition of the Young PRP showed lower levels of inflammatory molecules such as CCL-11, as well as the presence of other factors not found in Aged PRP (GDF-11). Although both PRPs had effects in terms of reducing neural progenitor cell apoptosis, stabilizing neuronal synapses, and decreasing inflammation in the microglia, the effect of the Young PRP was more pronounced. In conclusion, the molecular composition of the PRP, conditioned by the age of the donors, affects the magnitude of the biological response.Platelet-rich plasma (PRP) is a biologic therapy that promotes healing responses across multiple medical fields, including the central nervous system (CNS). The efficacy of this therapy depends on several factors such as the donor's health status and age. This work aims to prove the effect of PRP on cellular models of the CNS, considering the differences between PRP from young and elderly donors. Two different PRP pools were prepared from donors 65‒85 and 20‒25 years old. The cellular and molecular composition of both PRPs were analyzed. Subsequently, the cellular response was evaluated in CNS in vitro models, studying proliferation, neurogenesis, synaptogenesis, and inflammation. While no differences in the cellular composition of PRPs were found, the molecular composition of the Young PRP showed lower levels of inflammatory molecules such as CCL-11, as well as the presence of other factors not found in Aged PRP (GDF-11). Although both PRPs had effects in terms of reducing neural progenitor cell apoptosis, stabilizing neuronal synapses, and decreasing inflammation in the microglia, the effect of the Young PRP was more pronounced. In conclusion, the molecular composition of the PRP, conditioned by the age of the donors, affects the magnitude of the biological response. |
| Author | López De Jesús, Maider Beitia, Maider Isasti, Amaia Montilla, Alejandro Sallés, Joan Sánchez, Pello Zuazo-Ibarra, Jone Sánchez, Mikel Capetillo-Zarate, Estibaliz Matute, Carlos González-Burguera, Imanol Bilbao, Ane Miren Delgado, Diego Garate, Ane Domercq, María García del Caño, Gontzal |
| AuthorAffiliation | 8 IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain 2 Arthroscopic Surgery Unit, Hospital Vithas Vitoria, 01008 Vitoria-Gasteiz, Spain; anemiren.bilbao@ucatrauma.com 6 Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain 1 Advanced Biological Therapy Unit, Hospital Vithas Vitoria, 01008 Vitoria-Gasteiz, Spain; diego.delgado@ucatrauma.com (D.D.); maider.beitia@ucatrauma.com (M.B.); ane.garate@ucatrauma.com (A.G.); pello.sanchez@ucatrauma.com (P.S.) 7 Achucarro Basque Center for Neuroscience, CIBERNED and Departamento de Neurociencias, Universidad del País Vasco (UPV/EHU), 48940 Leioa, Spain; jone.zuazo@ehu.eus (J.Z.-I.); alejandro.montilla@ehu.eus (A.M.); maria.domercq@ehu.eus (M.D.); estibaliz.capetillo@ehu.eus (E.C.-Z.); carlos.matute@ehu.eus (C.M.) 4 Bioaraba, Neurofarmacología Celular y Molecular, 01008 Vitoria-Gasteiz, Spain; amaia.isasti@ehu.eus (A.I.); maider.lopez@ehu.eus (M.L.D.J.); joan.salles@ehu.eus (J.S.) 3 Department of Neuroscien |
| AuthorAffiliation_xml | – name: 6 Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 28029 Madrid, Spain – name: 5 Department of Pharmacology, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), 01008 Vitoria-Gasteiz, Spain – name: 8 IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain – name: 4 Bioaraba, Neurofarmacología Celular y Molecular, 01008 Vitoria-Gasteiz, Spain; amaia.isasti@ehu.eus (A.I.); maider.lopez@ehu.eus (M.L.D.J.); joan.salles@ehu.eus (J.S.) – name: 1 Advanced Biological Therapy Unit, Hospital Vithas Vitoria, 01008 Vitoria-Gasteiz, Spain; diego.delgado@ucatrauma.com (D.D.); maider.beitia@ucatrauma.com (M.B.); ane.garate@ucatrauma.com (A.G.); pello.sanchez@ucatrauma.com (P.S.) – name: 7 Achucarro Basque Center for Neuroscience, CIBERNED and Departamento de Neurociencias, Universidad del País Vasco (UPV/EHU), 48940 Leioa, Spain; jone.zuazo@ehu.eus (J.Z.-I.); alejandro.montilla@ehu.eus (A.M.); maria.domercq@ehu.eus (M.D.); estibaliz.capetillo@ehu.eus (E.C.-Z.); carlos.matute@ehu.eus (C.M.) – name: 3 Department of Neurosciences, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), 01008 Vitoria-Gasteiz, Spain; imanol.gonzalezb@ehu.eus (I.G.-B.); gontzal.garcia@ehu.eus (G.G.d.C.) – name: 2 Arthroscopic Surgery Unit, Hospital Vithas Vitoria, 01008 Vitoria-Gasteiz, Spain; anemiren.bilbao@ucatrauma.com |
| Author_xml | – sequence: 1 givenname: Diego orcidid: 0000-0002-0494-0804 surname: Delgado fullname: Delgado, Diego – sequence: 2 givenname: Ane Miren surname: Bilbao fullname: Bilbao, Ane Miren – sequence: 3 givenname: Maider surname: Beitia fullname: Beitia, Maider – sequence: 4 givenname: Ane surname: Garate fullname: Garate, Ane – sequence: 5 givenname: Pello surname: Sánchez fullname: Sánchez, Pello – sequence: 6 givenname: Imanol surname: González-Burguera fullname: González-Burguera, Imanol – sequence: 7 givenname: Amaia surname: Isasti fullname: Isasti, Amaia – sequence: 8 givenname: Maider surname: López De Jesús fullname: López De Jesús, Maider – sequence: 9 givenname: Jone surname: Zuazo-Ibarra fullname: Zuazo-Ibarra, Jone – sequence: 10 givenname: Alejandro orcidid: 0000-0003-0491-3360 surname: Montilla fullname: Montilla, Alejandro – sequence: 11 givenname: María orcidid: 0000-0002-4918-9276 surname: Domercq fullname: Domercq, María – sequence: 12 givenname: Estibaliz surname: Capetillo-Zarate fullname: Capetillo-Zarate, Estibaliz – sequence: 13 givenname: Gontzal orcidid: 0000-0002-7098-0986 surname: García del Caño fullname: García del Caño, Gontzal – sequence: 14 givenname: Joan surname: Sallés fullname: Sallés, Joan – sequence: 15 givenname: Carlos surname: Matute fullname: Matute, Carlos – sequence: 16 givenname: Mikel surname: Sánchez fullname: Sánchez, Mikel |
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| Keywords | aging growth factors microglia neurons platelet-rich plasma central nervous system |
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