Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage

Internalization of ligand-activated type I IGF receptor (IGF1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear IGF1R reportedly associates with clinical response to IGF1R inhibitory drugs, yet its role in the nucleus is poorly characterized. Here, we i...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 78; H. 13; S. 3497
Hauptverfasser:	Aleksic, Tamara, Gray, Nicki, Wu, Xiaoning, Rieunier, Guillaume, Osher, Eliot, Mills, Jack, Verrill, Clare, Bryant, Richard J, Han, Cheng, Hutchinson, Kathryn, Lambert, Adam G, Kumar, Rajeev, Hamdy, Freddie C, Weyer-Czernilofsky, Ulrike, Sanderson, Michael P, Bogenrieder, Thomas, Taylor, Stephen, Macaulay, Valentine M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2018
Schlagworte:	Aged Cell Line, Tumor Cell Movement - genetics Cell Nucleus - pathology Cell Survival - genetics Chromatin - genetics Chromatin - metabolism Gene Expression Regulation, Neoplastic - genetics Humans Insulin-Like Growth Factor I - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Male Middle Aged Neoplasm Staging Promoter Regions, Genetic - genetics Prostatectomy Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Receptor, IGF Type 1 Receptors, Somatomedin - metabolism RNA Polymerase II - metabolism Signal Transduction - genetics Transcription Initiation Site Up-Regulation
ISSN:	1538-7445, 1538-7445
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