Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination

It is well established that interferon gamma (IFN-γ) production by CD4 T cells is critical for antiviral immunity against herpes simplex virus 2 (HSV-2) genital infection. However, the role of interleukin-17A (IL-17A) production by CD4 T cells in HSV-2 antiviral immunity is yet to be elucidated. Her...

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Bibliographic Details
Published in:	Journal of virology Vol. 91; no. 23
Main Authors:	Bagri, Puja, Anipindi, Varun C, Nguyen, Philip V, Vitali, Danielle, Stämpfli, Martin R, Kaushic, Charu
Format:	Journal Article
Language:	English
Published:	United States 01.12.2017
Subjects:	Animals Antibodies, Viral - biosynthesis Antibodies, Viral - blood CD4-Positive T-Lymphocytes - immunology Chemokines - biosynthesis Cytokines - biosynthesis Female Genitalia, Female - immunology Genitalia, Female - virology Herpes Genitalis - immunology Herpes Genitalis - prevention & control Herpesvirus 2, Human - immunology Herpesvirus Vaccines - administration & dosage Herpesvirus Vaccines - immunology Immunologic Memory Interleukin-17 - deficiency Interleukin-17 - immunology Mice Mice, Inbred C57BL Mucous Membrane - virology Th1 Cells - immunology Vagina - immunology Virus Shedding herpes simplex virus sexually transmitted diseases CD4 T cell immunity genital tract immunity IL-17 mucosal immunity
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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