Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains

The role of mutations in genes associated with phenotypic resistance to bedaquiline (BDQ) and delamanid (DLM) in complex (MTBc) strains is poorly characterized. A clear understanding of the genetic variants' role is crucial to guide the development of molecular-based drug susceptibility testing...

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Veröffentlicht in:	Journal of clinical microbiology Jg. 58; H. 11
Hauptverfasser:	Battaglia, S, Spitaleri, A, Cabibbe, A M, Meehan, C J, Utpatel, C, Ismail, N, Tahseen, S, Skrahina, A, Alikhanova, N, Mostofa Kamal, S M, Barbova, A, Niemann, S, Groenheit, R, Dean, A S, Zignol, M, Rigouts, L, Cirillo, D M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.10.2020
Schlagworte:	Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Diarylquinolines - pharmacology Genomics Humans Microbial Sensitivity Tests Mycobacterium tuberculosis - genetics Nitroimidazoles Oxazoles Tuberculosis, Multidrug-Resistant - drug therapy delamanid resistance to new drugs Mycobacterium tuberculosis bedaquiline whole-genome sequencing
ISSN:	1098-660X, 1098-660X
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