Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time

The HIV-1 Rev response element (RRE) is a -acting RNA element characterized by multiple stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promote the nucleocytoplasmic export of incompletely spliced mRNAs, an essential step in HIV replication. Most of our understanding of the...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Journal of virology Ročník 93; číslo 11
Hlavní autoři:	Sherpa, Chringma, Jackson, Patrick E H, Gray, Laurie R, Anastos, Kathryn, Le Grice, Stuart F J, Hammarskjold, Marie-Louise, Rekosh, David
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.06.2019
Témata:	Gene Products, rev - genetics Genes, env - genetics Genes, env - physiology HIV Infections - virology HIV Seropositivity - genetics HIV-1 - metabolism HIV-1 - physiology Humans Mutation Nucleic Acid Conformation Nucleotides - metabolism Protein Binding Response Elements - genetics rev Gene Products, Human Immunodeficiency Virus - metabolism rev Gene Products, Human Immunodeficiency Virus - ultrastructure RNA, Messenger - genetics RNA, Viral - genetics Virus Replication - genetics RNA export HIV HIV RRE HIV Rev viral sequence evolution viral sequence variation RNA structure
ISSN:	1098-5514, 1098-5514
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!