How Have Animal Models Increased our Understanding of Human Myopia?

The extent to which animal models of refractive development have increased our understanding of human myopia is reviewed. During postnatal development refractive errors converge on emmetropia in young animals but form deprivation disrupts this process. Their eyes compensate for optically imposed myo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Investigative ophthalmology & visual science Jg. 66; H. 7; S. 2
1. Verfasser: Bullimore, Mark A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States The Association for Research in Vision and Ophthalmology 05.06.2025
Schlagworte:
Animals
Disease Models, Animal
Humans
Myopia - physiopathology
Refraction, Ocular - physiology
Special Issue
ISSN:1552-5783, 0146-0404, 1552-5783
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The extent to which animal models of refractive development have increased our understanding of human myopia is reviewed. During postnatal development refractive errors converge on emmetropia in young animals but form deprivation disrupts this process. Their eyes compensate for optically imposed myopic or hyperopic defocus and recover from the induced refractive error when form deprivation or optical defocus is removed. All of these features have, to some extent, been observed in young children. The lens paradigm has been further leveraged in animals to investigate the influence of competing optical signals on refractive error. These, in turn, have informed and validated certain myopia control technologies. Short-term choroidal thickening and thinning can be induced by positive and negative lenses, respectively, in both animals and humans, although these changes are much smaller and more variable in the latter. Finally, inconsistencies among animal models, inconsistencies between animal models and human myopia, and knowledge gaps and opportunities are discussed.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.66.7.2