How Have Animal Models Increased our Understanding of Human Myopia?
The extent to which animal models of refractive development have increased our understanding of human myopia is reviewed. During postnatal development refractive errors converge on emmetropia in young animals but form deprivation disrupts this process. Their eyes compensate for optically imposed myo...
Uloženo v:
| Vydáno v: | Investigative ophthalmology & visual science Ročník 66; číslo 7; s. 2 |
|---|---|
| Hlavní autor: | |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
The Association for Research in Vision and Ophthalmology
05.06.2025
|
| Témata: | |
| ISSN: | 1552-5783, 0146-0404, 1552-5783 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Shrnutí: | The extent to which animal models of refractive development have increased our understanding of human myopia is reviewed. During postnatal development refractive errors converge on emmetropia in young animals but form deprivation disrupts this process. Their eyes compensate for optically imposed myopic or hyperopic defocus and recover from the induced refractive error when form deprivation or optical defocus is removed. All of these features have, to some extent, been observed in young children. The lens paradigm has been further leveraged in animals to investigate the influence of competing optical signals on refractive error. These, in turn, have informed and validated certain myopia control technologies. Short-term choroidal thickening and thinning can be induced by positive and negative lenses, respectively, in both animals and humans, although these changes are much smaller and more variable in the latter. Finally, inconsistencies among animal models, inconsistencies between animal models and human myopia, and knowledge gaps and opportunities are discussed. |
|---|---|
| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 1552-5783 0146-0404 1552-5783 |
| DOI: | 10.1167/iovs.66.7.2 |