Differential effects of mechano‐electric feedback mechanisms on whole‐heart activation, repolarization, and tension

The human heart is subject to highly variable amounts of strain during day‐to‐day activities and needs to adapt to a wide range of physiological demands. This adaptation is driven by an autoregulatory loop that includes both electrical and the mechanical components. In particular, mechanical forces...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of physiology Vol. 602; no. 18; pp. 4605 - 4624
Main Authors:	Gerach, Tobias, Loewe, Axel
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.09.2024
Subjects:	Calcium channels Calcium channels (voltage-gated) Computer applications computer modelling and simulation Electrophysiology Feedback Heart Mathematical models Mechanical properties mechano‐electric feedback monodomain Myocardium Physiology repolarization gradient Sinuses stretch‐activated channels Troponin computer modelling and simulation repolarization gradient mechano‐electric feedback monodomain stretch‐activated channels
ISSN:	0022-3751, 1469-7793, 1469-7793
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!