Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway

Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate i...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 131; pp. 225 - 236
Main Authors:	Chen, Xuemei, Hu, Yuan, Zhang, Wenlu, Chen, Ke, Hu, Jie, Li, Xiaosong, Liang, Li, Cai, Xuefei, Hu, Jieli, Wang, Kai, Huang, Ailong, Tang, Ni
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2019
Subjects:	Acetylcysteine - pharmacology Adenine - analogs & derivatives Adenine - pharmacology Animals Antineoplastic Agents - pharmacology Autophagy Autophagy - drug effects Autophagy - genetics Autophagy-Related Protein 5 - antagonists & inhibitors Autophagy-Related Protein 5 - genetics Autophagy-Related Protein 5 - metabolism Chloroquine - pharmacology Cisplatin Cisplatin - pharmacology Gene Expression Regulation Genes, Reporter Hep G2 Cells Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - growth & development Hepatitis B virus - metabolism Hepatitis B virus reactivation Hepatitis B virus replication Hepatitis B, Chronic - genetics Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - virology Humans Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Red Fluorescent Protein RNA, Small Interfering - genetics RNA, Small Interfering - metabolism ROS/JNK signaling pathway Sequestosome-1 Protein - genetics Sequestosome-1 Protein - metabolism Signal Transduction TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Virus Activation - drug effects Virus Replication - drug effects Hepatitis B virus replication ALT MDA Autophagy CQ Cisplatin NAC LC3II pgRNA ROS 3-MA Hepatitis B virus reactivation HBV RFP SQSTM1 ROS/JNK signaling pathway
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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