PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Both the programmed death (PD) 1-PD-ligand (PD-L) pathway and regulatory T (T reg) cells are instrumental to the maintenance of peripheral tolerance. We demonstrate that PD-L1 has a pivotal role in regulating induced T reg (iT reg) cell development and sustaining iT reg cell function. PD-L1(-/-) ant...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 206; no. 13; p. 3015
Main Authors:	Francisco, Loise M, Salinas, Victor H, Brown, Keturah E, Vanguri, Vijay K, Freeman, Gordon J, Kuchroo, Vijay K, Sharpe, Arlene H
Format:	Journal Article
Language:	English
Published:	United States 21.12.2009
Subjects:	Animals B7-1 Antigen - physiology B7-H1 Antigen Carrier Proteins - physiology Forkhead Transcription Factors - physiology Leukocyte Common Antigens - analysis Lung - pathology Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Peptides - physiology Phosphotransferases (Alcohol Group Acceptor) - physiology Programmed Cell Death 1 Ligand 2 Protein Proto-Oncogene Proteins c-akt - physiology Signal Transduction T-Lymphocytes, Regulatory - physiology TOR Serine-Threonine Kinases Transforming Growth Factor beta - physiology
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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