Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum

Bridging the gap between cortical morphometric remodeling and gene expression can help to clarify the effects of the selective brain accumulation of Amyloid-β (Aβ) and tau proteins occurring in the Alzheimer’s disease (AD). To this aim, we derived morphometric similarity (MS) networks from 126 Aβ- a...

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Vydané v:International journal of molecular sciences Ročník 25; číslo 23; s. 12871
Hlavní autori: Brusini, Lorenza, Dolci, Giorgio, Pini, Lorenzo, Cruciani, Federica, Pizzagalli, Fabrizio, Provero, Paolo, Menegaz, Gloria, Boscolo Galazzo, Ilaria
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 01.12.2024
Predmet:
Advertising executives
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Amyloid beta-Peptides - genetics
Amyloid beta-Peptides - metabolism
Brain
Brain - metabolism
Brain - pathology
Development and progression
Diseases
Female
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genomics
Humans
Italy
Kinases
Magnetic resonance imaging
Male
Proteins
tau Proteins - genetics
tau Proteins - metabolism
Tissues
Transcriptome
Italy
ADNI
diffusion MRI
T1-weighted MRI
partial least squares
gene expression
enrichment analysis
ISSN:1422-0067, 1661-6596, 1422-0067
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Shrnutí:Bridging the gap between cortical morphometric remodeling and gene expression can help to clarify the effects of the selective brain accumulation of Amyloid-β (Aβ) and tau proteins occurring in the Alzheimer’s disease (AD). To this aim, we derived morphometric similarity (MS) networks from 126 Aβ- and tau-positive (Aβ+/tau+) and 172 Aβ−/tau− subjects, and we investigated the association between group-wise regional MS differences and transcriptional correlates thanks to an imaging transcriptomics approach grounded in the Allen Human Brain Atlas (AHBA). The expressed gene with the highest correlation with MS alterations was BCHE, a gene related to Aβ homeostasis. In addition, notably, among the most promising results derived from the enrichment analysis, we found the immune response to be a biological process and astrocytes, microglia, and oligodendrocyte precursors for the cell types. In summary, by relating cortical MS and AHBA-derived transcriptomics, we were able to retrieve findings suggesting the biological mechanisms underlying the Aβ- and tau- induced cortical MS alterations in the AD continuum.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252312871