Morphometric Similarity Patterning of Amyloid-β and Tau Proteins Correlates with Transcriptomics in the Alzheimer’s Disease Continuum

Bridging the gap between cortical morphometric remodeling and gene expression can help to clarify the effects of the selective brain accumulation of Amyloid-β (Aβ) and tau proteins occurring in the Alzheimer’s disease (AD). To this aim, we derived morphometric similarity (MS) networks from 126 Aβ- a...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 25; no. 23; p. 12871
Main Authors:	Brusini, Lorenza, Dolci, Giorgio, Pini, Lorenzo, Cruciani, Federica, Pizzagalli, Fabrizio, Provero, Paolo, Menegaz, Gloria, Boscolo Galazzo, Ilaria
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.12.2024
Subjects:	Advertising executives Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Brain Brain - metabolism Brain - pathology Development and progression Diseases Female Gene expression Gene Expression Profiling Genes Genetic aspects Genomics Humans Italy Kinases Magnetic resonance imaging Male Proteins tau Proteins - genetics tau Proteins - metabolism Tissues Transcriptome Italy ADNI diffusion MRI T1-weighted MRI partial least squares gene expression enrichment analysis
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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