An optimized and automated approach to quantifying channelrhodopsin photocurrent kinetics

Channelrhodopsins are light-activated ion channels that enable targetable activation or inhibition of excitable cells with light. Ion conductance can generally be described by a four step photocycle, which includes two open and two closed states. While a complete understanding of channelrhodopsin fu...

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Bibliographic Details

Published in:	Analytical biochemistry Vol. 566; pp. 160 - 167
Main Authors:	Prignano, Lindsey, Faal, Siamak G., Hera, Adriana, Dempski, Robert E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2019
Subjects:	automation Channelrhodopsin electric current Electrophysiology ion channels Kinetic modeling Neuroscience Optogenetics quantitative analysis Electrophysiology Neuroscience Optogenetics Kinetic modeling Channelrhodopsin
ISSN:	0003-2697, 1096-0309, 1096-0309
Online Access:	Get full text
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