The Sirt1 Activator SRT1720 Mitigates Human Monocyte Activation and Improves Outcome During Gram-Negative Pneumosepsis in Mice

Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, regulating metabolism and epigenetics, may be fundamental in activating the innate immune response. Sirt1 mRNA expression was significantly re...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	International journal of molecular sciences Ročník 26; číslo 19; s. 9309
Hlavní autori:	Blot, Mathieu, Léopold, Valentine, de Beer, Regina, Florquin, Sandrine, Butler, Joe M., van’t Veer, Cornelis, de Vos, Alex F., van der Poll, Tom
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 01.10.2025
Predmet:	Aged Analysis Animals Apoptosis Bacterial pneumonia Blood clots Cytokines Disease Models, Animal Epigenetic inheritance Female Heterocyclic Compounds, 4 or More Rings - pharmacology Heterocyclic Compounds, 4 or More Rings - therapeutic use Humans Immune response Infections Inflammation Interleukin-6 - metabolism Liver Lung - microbiology Lung - pathology Lungs Male Metabolism Mice Middle Aged Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Neutrophils Pathogens Pathology Patient outcomes Physiological aspects Plasma Pneumonia Pneumonia, Bacterial - drug therapy RNA Sepsis Sirtuin 1 - genetics Sirtuin 1 - metabolism THP-1 Cells Netherlands France United States Illinois SRT1720 monocyte activation pneumonia immune response Sirt1 lipopolysaccharide Klebsiella pneumoniae
ISSN:	1422-0067, 1661-6596, 1422-0067
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, regulating metabolism and epigenetics, may be fundamental in activating the innate immune response. Sirt1 mRNA expression was significantly reduced in monocytes from CAP patients (n = 76) upon admission compared to healthy controls (n = 42), with levels returning to normal after 30 days. Pharmacological activation of Sirt1 with SRT1720 decreased LPS- and K. pneumoniae-induced IL-6 release in primary human monocytes and decreased NF-κB activation in THP1 cells. In a mouse K. pneumoniae pneumosepsis model, SRT1720 strongly reduced neutrophil influx and degranulation markers in bronchoalveolar lavage fluid, lowered pulmonary concentrations of IL-6 and TNF-α, and reduced lung pathology scores. Simultaneously, it reduced neutrophil content in liver tissue and plasma transaminase levels, alongside a trend toward reduced liver necrosis. Plasma IL-6 and TNF-α were significantly lower in SRT1720-treated mice at 42 h. Finally, while SRT1720 did not impact bacterial loads in the lungs, it reduced bacterial burden in blood, with a similar trend observed in liver homogenates. In conclusion, the Sirt1 activator SRT1720 exerts anti-inflammatory effects on human monocytes, reduces local and systemic inflammation and organ injury, and diminishes bacterial dissemination in murine pneumosepsis.
AbstractList	Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, regulating metabolism and epigenetics, may be fundamental in activating the innate immune response. Sirt1 mRNA expression was significantly reduced in monocytes from CAP patients (n = 76) upon admission compared to healthy controls (n = 42), with levels returning to normal after 30 days. Pharmacological activation of Sirt1 with SRT1720 decreased LPS- and K. pneumoniae-induced IL-6 release in primary human monocytes and decreased NF-κB activation in THP1 cells. In a mouse K. pneumoniae pneumosepsis model, SRT1720 strongly reduced neutrophil influx and degranulation markers in bronchoalveolar lavage fluid, lowered pulmonary concentrations of IL-6 and TNF-α, and reduced lung pathology scores. Simultaneously, it reduced neutrophil content in liver tissue and plasma transaminase levels, alongside a trend toward reduced liver necrosis. Plasma IL-6 and TNF-α were significantly lower in SRT1720-treated mice at 42 h. Finally, while SRT1720 did not impact bacterial loads in the lungs, it reduced bacterial burden in blood, with a similar trend observed in liver homogenates. In conclusion, the Sirt1 activator SRT1720 exerts anti-inflammatory effects on human monocytes, reduces local and systemic inflammation and organ injury, and diminishes bacterial dissemination in murine pneumosepsis. Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, regulating metabolism and epigenetics, may be fundamental in activating the innate immune response. Sirt1 mRNA expression was significantly reduced in monocytes from CAP patients ( = 76) upon admission compared to healthy controls ( = 42), with levels returning to normal after 30 days. Pharmacological activation of Sirt1 with SRT1720 decreased LPS- and -induced IL-6 release in primary human monocytes and decreased NF-κB activation in THP1 cells. In a mouse pneumosepsis model, SRT1720 strongly reduced neutrophil influx and degranulation markers in bronchoalveolar lavage fluid, lowered pulmonary concentrations of IL-6 and TNF-α, and reduced lung pathology scores. Simultaneously, it reduced neutrophil content in liver tissue and plasma transaminase levels, alongside a trend toward reduced liver necrosis. Plasma IL-6 and TNF-α were significantly lower in SRT1720-treated mice at 42 h. Finally, while SRT1720 did not impact bacterial loads in the lungs, it reduced bacterial burden in blood, with a similar trend observed in liver homogenates. In conclusion, the Sirt1 activator SRT1720 exerts anti-inflammatory effects on human monocytes, reduces local and systemic inflammation and organ injury, and diminishes bacterial dissemination in murine pneumosepsis. Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, regulating metabolism and epigenetics, may be fundamental in activating the innate immune response. Sirt1 mRNA expression was significantly reduced in monocytes from CAP patients (n = 76) upon admission compared to healthy controls (n = 42), with levels returning to normal after 30 days. Pharmacological activation of Sirt1 with SRT1720 decreased LPS- and K. pneumoniae-induced IL-6 release in primary human monocytes and decreased NF-κB activation in THP1 cells. In a mouse K. pneumoniae pneumosepsis model, SRT1720 strongly reduced neutrophil influx and degranulation markers in bronchoalveolar lavage fluid, lowered pulmonary concentrations of IL-6 and TNF-α, and reduced lung pathology scores. Simultaneously, it reduced neutrophil content in liver tissue and plasma transaminase levels, alongside a trend toward reduced liver necrosis. Plasma IL-6 and TNF-α were significantly lower in SRT1720-treated mice at 42 h. Finally, while SRT1720 did not impact bacterial loads in the lungs, it reduced bacterial burden in blood, with a similar trend observed in liver homogenates. In conclusion, the Sirt1 activator SRT1720 exerts anti-inflammatory effects on human monocytes, reduces local and systemic inflammation and organ injury, and diminishes bacterial dissemination in murine pneumosepsis.Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase, regulating metabolism and epigenetics, may be fundamental in activating the innate immune response. Sirt1 mRNA expression was significantly reduced in monocytes from CAP patients (n = 76) upon admission compared to healthy controls (n = 42), with levels returning to normal after 30 days. Pharmacological activation of Sirt1 with SRT1720 decreased LPS- and K. pneumoniae-induced IL-6 release in primary human monocytes and decreased NF-κB activation in THP1 cells. In a mouse K. pneumoniae pneumosepsis model, SRT1720 strongly reduced neutrophil influx and degranulation markers in bronchoalveolar lavage fluid, lowered pulmonary concentrations of IL-6 and TNF-α, and reduced lung pathology scores. Simultaneously, it reduced neutrophil content in liver tissue and plasma transaminase levels, alongside a trend toward reduced liver necrosis. Plasma IL-6 and TNF-α were significantly lower in SRT1720-treated mice at 42 h. Finally, while SRT1720 did not impact bacterial loads in the lungs, it reduced bacterial burden in blood, with a similar trend observed in liver homogenates. In conclusion, the Sirt1 activator SRT1720 exerts anti-inflammatory effects on human monocytes, reduces local and systemic inflammation and organ injury, and diminishes bacterial dissemination in murine pneumosepsis.
Audience	Academic
Author	de Vos, Alex F. Léopold, Valentine van’t Veer, Cornelis Blot, Mathieu de Beer, Regina Butler, Joe M. van der Poll, Tom Florquin, Sandrine
Author_xml	– sequence: 1 givenname: Mathieu orcidid: 0000-0001-6541-2434 surname: Blot fullname: Blot, Mathieu – sequence: 2 givenname: Valentine orcidid: 0000-0002-2131-5760 surname: Léopold fullname: Léopold, Valentine – sequence: 3 givenname: Regina surname: de Beer fullname: de Beer, Regina – sequence: 4 givenname: Sandrine surname: Florquin fullname: Florquin, Sandrine – sequence: 5 givenname: Joe M. surname: Butler fullname: Butler, Joe M. – sequence: 6 givenname: Cornelis surname: van’t Veer fullname: van’t Veer, Cornelis – sequence: 7 givenname: Alex F. orcidid: 0000-0002-2472-3014 surname: de Vos fullname: de Vos, Alex F. – sequence: 8 givenname: Tom surname: van der Poll fullname: van der Poll, Tom
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/41096578$$D View this record in MEDLINE/PubMed
BookMark	eNpt0s9PHCEUB3BibPzV3jw3JF566OgDZnbguLGtmvijqdvzhGXerGwW2AKziZf-7cWqrTYNBwj58OWFxz7Z9sEjIYcMjoVQcGKXLvEJU0qA2iJ7rOa8Api02y_Wu2Q_pSUAF7xRO2S3ZqAmTSv3yM_ZHdJbGzOjU5PtRucQ6e23GWs50Cub7UJnTPR8dNrTq-CDuc_4TG3wVPueXrh1DJvCbsZsgkP6aYzWL-hZ1K66xhJhN0i_ehxdSLhONlFb0qzBt-TNoFcJ3z3NB-T7l8-z0_Pq8ubs4nR6WRkhRa5aYUByow0MiknBQPO5YbJu2h647EENjMmhHxigUZwBN6afN8gZokQFvTggHx5zS6E_Rky5czYZXK20xzCmTpQXbBVXsi706B-6DGP0pbrfCloFAv6qhV5hZ_0QctTmIbSbykapWvKGFXX8H1VGj86a0sfBlv1XB94_XT7OHfbdOlqn43333LACPj4CE0NKEYc_hEH38B-6l_9B_ALEMaWF
Cites_doi	10.1371/journal.pone.0098909 10.1097/TA.0000000000004212 10.1089/sur.2015.262 10.1111/j.1365-2141.2011.08888.x 10.3389/fimmu.2024.1448535 10.1128/MCB.00657-10 10.15252/embj.201695737 10.1038/nri.2016.136 10.21769/BioProtoc.4287 10.1016/j.cellsig.2022.110398 10.3389/fimmu.2016.00155 10.3389/fimmu.2021.778830 10.1016/j.immuni.2021.10.012 10.1371/journal.ppat.1002987 10.1038/s41572-021-00259-0 10.1097/SHK.0000000000000225 10.1080/21655979.2021.1987132 10.1038/s41401-018-0045-3 10.1186/s13073-021-00948-1 10.1074/jbc.M109.088682 10.1038/s41392-022-01232-3 10.1097/CCM.0000000000000949 10.1016/j.bbadis.2017.12.029 10.1080/14728222.2020.1743268 10.1038/nature06261 10.1182/blood-2017-06-788067 10.3109/15412555.2014.974740 10.1002/path.5601 10.1016/j.cmet.2017.06.001 10.1016/j.ejmech.2018.10.028 10.3389/fimmu.2024.1394925 10.1016/j.cbpa.2019.01.023 10.3389/fimmu.2022.831168 10.1097/TA.0000000000003751 10.14348/molcells.2016.2318 10.1155/2017/4082102
ContentType	Journal Article
Copyright	COPYRIGHT 2025 MDPI AG 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: COPYRIGHT 2025 MDPI AG – notice: 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8
DOI	10.3390/ijms26199309
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) Medical Database Research Library Research Library (Corporate) ProQuest Central Premium ProQuest One Academic ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic CrossRef Publicly Available Content Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	1422-0067
ExternalDocumentID	A859948251 41096578 10_3390_ijms26199309
Genre	Journal Article
GeographicLocations	Netherlands France United States Illinois
GeographicLocations_xml	– name: United States – name: Netherlands – name: France – name: Illinois
GrantInformation_xml	– fundername: CMIT (french college of university Professors in infectious Diseases) – fundername: RICAI (french congress of microbiology and infectious diseases) – fundername: ESCMID (European Society of Clinical Microbiology and Infectious Diseases)
GroupedDBID	--- 29J 2WC 53G 5GY 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ 8G5 A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AFFHD AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 DWQXO E3Z EBD EBS EJD ESX F5P FRP FYUFA GNUQQ GUQSH GX1 HH5 HMCUK HYE IAO IHR ITC KQ8 LK8 M1P M2O M48 MODMG O5R O5S OK1 OVT P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO RNS RPM TR2 TUS UKHRP ~8M CGR CUY CVF ECM EIF ESTFP NPM 3V. 7XB 8FK K9. MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8
ID	FETCH-LOGICAL-c383t-73c082cac0f918310a2bc18457d028d09f118fdf10ec92102ccdb5e21ee8e90d3
IEDL.DBID	BENPR
ISICitedReferencesCount	0
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001593662300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1422-0067 1661-6596
IngestDate	Sat Oct 18 22:56:31 EDT 2025 Thu Oct 16 08:26:37 EDT 2025 Sat Nov 29 13:46:19 EST 2025 Sat Nov 29 10:29:29 EST 2025 Mon Oct 20 01:42:04 EDT 2025 Sat Nov 29 07:23:19 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	19
Keywords	SRT1720 monocyte activation pneumonia immune response Sirt1 lipopolysaccharide Klebsiella pneumoniae
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c383t-73c082cac0f918310a2bc18457d028d09f118fdf10ec92102ccdb5e21ee8e90d3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0002-2131-5760 0000-0002-2472-3014 0000-0001-6541-2434
OpenAccessLink	https://www.proquest.com/docview/3261079030?pq-origsite=%requestingapplication%
PMID	41096578
PQID	3261079030
PQPubID	2032341
ParticipantIDs	proquest_miscellaneous_3261792984 proquest_journals_3261079030 gale_infotracmisc_A859948251 gale_infotracacademiconefile_A859948251 pubmed_primary_41096578 crossref_primary_10_3390_ijms26199309
PublicationCentury	2000
PublicationDate	2025-10-01
PublicationDateYYYYMMDD	2025-10-01
PublicationDate_xml	– month: 10 year: 2025 text: 2025-10-01 day: 01
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland – name: Basel
PublicationTitle	International journal of molecular sciences
PublicationTitleAlternate	Int J Mol Sci
PublicationYear	2025
Publisher	MDPI AG
Publisher_xml	– name: MDPI AG
References	Wang (ref_6) 2019; 161 Xu (ref_15) 2014; 42 Brands (ref_20) 2021; 13 Labiner (ref_17) 2022; 93 Pacholec (ref_35) 2010; 285 ref_36 ref_13 Scicluna (ref_18) 2015; 43 Soares (ref_3) 2017; 17 Tang (ref_27) 2016; 39 Jia (ref_14) 2018; 1864 Stienstra (ref_2) 2017; 26 Milne (ref_21) 2007; 450 Lewis (ref_4) 2016; 17 ref_16 Schug (ref_8) 2010; 30 Imperatore (ref_10) 2017; 36 Wang (ref_11) 2022; 97 Zhang (ref_32) 2017; 2017 Blok (ref_26) 2021; 253 Claushuis (ref_23) 2018; 131 Chauhan (ref_22) 2011; 155 Kosciuk (ref_5) 2019; 51 ref_25 Torres (ref_1) 2021; 7 ref_24 Xie (ref_30) 2021; 12 Gu (ref_31) 2015; 12 Wiersinga (ref_34) 2021; 54 Vachharajani (ref_7) 2020; 24 Fu (ref_33) 2019; 40 ref_29 ref_28 ref_9 Liu (ref_12) 2023; 8 Labiner (ref_19) 2024; 96
References_xml	– ident: ref_16 doi: 10.1371/journal.pone.0098909 – volume: 96 start-page: 557 year: 2024 ident: ref_19 article-title: SIRT1 downregulation in pneumonia is associated with an immature neutrophil response and increased disease severity publication-title: J. Trauma Acute Care Surg. doi: 10.1097/TA.0000000000004212 – volume: 17 start-page: 286 year: 2016 ident: ref_4 article-title: Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy publication-title: Surg. Infect. doi: 10.1089/sur.2015.262 – volume: 155 start-page: 588 year: 2011 ident: ref_22 article-title: Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2011.08888.x – ident: ref_28 doi: 10.3389/fimmu.2024.1448535 – volume: 30 start-page: 4712 year: 2010 ident: ref_8 article-title: Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00657-10 – volume: 36 start-page: 2353 year: 2017 ident: ref_10 article-title: SIRT1 regulates macrophage self-renewal publication-title: EMBO J. doi: 10.15252/embj.201695737 – volume: 17 start-page: 83 year: 2017 ident: ref_3 article-title: Disease tolerance and immunity in host protection against infection publication-title: Nat. Rev. Immunol. doi: 10.1038/nri.2016.136 – ident: ref_25 doi: 10.21769/BioProtoc.4287 – volume: 97 start-page: 110398 year: 2022 ident: ref_11 article-title: SIRT1 ameliorated septic associated-lung injury and macrophages apoptosis via inhibiting endoplasmic reticulum stress publication-title: Cell. Signal. doi: 10.1016/j.cellsig.2022.110398 – ident: ref_29 doi: 10.3389/fimmu.2016.00155 – ident: ref_36 doi: 10.3389/fimmu.2021.778830 – volume: 54 start-page: 2450 year: 2021 ident: ref_34 article-title: The immunology of sepsis publication-title: Immunity doi: 10.1016/j.immuni.2021.10.012 – ident: ref_24 doi: 10.1371/journal.ppat.1002987 – volume: 7 start-page: 25 year: 2021 ident: ref_1 article-title: Pneumonia publication-title: Nat. Rev. Dis. Primers doi: 10.1038/s41572-021-00259-0 – volume: 42 start-page: 440 year: 2014 ident: ref_15 article-title: Novel role of resveratrol: Suppression of high-mobility group protein box 1 nucleocytoplasmic translocation by the upregulation of sirtuin 1 in sepsis-induced liver injury publication-title: Shock doi: 10.1097/SHK.0000000000000225 – volume: 12 start-page: 9723 year: 2021 ident: ref_30 article-title: Overexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p/Sirtuin-1 pathway publication-title: Bioengineered doi: 10.1080/21655979.2021.1987132 – volume: 40 start-page: 630 year: 2019 ident: ref_33 article-title: Activation of SIRT1 ameliorates LPS-induced lung injury in mice via decreasing endothelial tight junction permeability publication-title: Acta Pharmacol. Sin. doi: 10.1038/s41401-018-0045-3 – volume: 13 start-page: 131 year: 2021 ident: ref_20 article-title: An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration publication-title: Genome Med. doi: 10.1186/s13073-021-00948-1 – volume: 285 start-page: 8340 year: 2010 ident: ref_35 article-title: SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.088682 – volume: 8 start-page: 38 year: 2023 ident: ref_12 article-title: Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation publication-title: Signal Transduct. Target. Ther. doi: 10.1038/s41392-022-01232-3 – volume: 43 start-page: e199 year: 2015 ident: ref_18 article-title: The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans publication-title: Crit. Care Med. doi: 10.1097/CCM.0000000000000949 – volume: 1864 start-page: 784 year: 2018 ident: ref_14 article-title: SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA publication-title: Biochim. Biophys. Acta (BBA)—Mol. Basis Dis. doi: 10.1016/j.bbadis.2017.12.029 – volume: 24 start-page: 489 year: 2020 ident: ref_7 article-title: Sirtuins: Potential therapeutic targets for regulating acute inflammatory response? publication-title: Expert Opin. Ther. Targets doi: 10.1080/14728222.2020.1743268 – volume: 450 start-page: 712 year: 2007 ident: ref_21 article-title: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes publication-title: Nature doi: 10.1038/nature06261 – volume: 131 start-page: 864 year: 2018 ident: ref_23 article-title: Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria publication-title: Blood doi: 10.1182/blood-2017-06-788067 – volume: 12 start-page: 444 year: 2015 ident: ref_31 article-title: Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema publication-title: COPD doi: 10.3109/15412555.2014.974740 – volume: 253 start-page: 374 year: 2021 ident: ref_26 article-title: Interleukin-33 improves local immunity during Gram-negative pneumonia by a combined effect on neutrophils and inflammatory monocytes publication-title: J. Pathol. doi: 10.1002/path.5601 – volume: 26 start-page: 142 year: 2017 ident: ref_2 article-title: Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune Responses publication-title: Cell Metab. doi: 10.1016/j.cmet.2017.06.001 – volume: 161 start-page: 48 year: 2019 ident: ref_6 article-title: An overview of Sirtuins as potential therapeutic target: Structure, function and modulators publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.10.028 – ident: ref_13 doi: 10.3389/fimmu.2024.1394925 – volume: 51 start-page: 18 year: 2019 ident: ref_5 article-title: Updates on the epigenetic roles of sirtuins publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2019.01.023 – ident: ref_9 doi: 10.3389/fimmu.2022.831168 – volume: 93 start-page: 672 year: 2022 ident: ref_17 article-title: Sirtuin 1 deletion increases inflammation and mortality in sepsis publication-title: J. Trauma Acute Care Surg. doi: 10.1097/TA.0000000000003751 – volume: 39 start-page: 87 year: 2016 ident: ref_27 article-title: Sirt1 and the Mitochondria publication-title: Mol. Cells doi: 10.14348/molcells.2016.2318 – volume: 2017 start-page: 4082102 year: 2017 ident: ref_32 article-title: Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction publication-title: Oxidative Med. Cell. Longev. doi: 10.1155/2017/4082102
SSID	ssj0023259
Score	2.445097
Snippet	Community-acquired pneumonia (CAP) is a leading cause of death, with mortality linked to an unbalanced host response. Sirtuin (Sirt)1, a histone deacetylase,...
SourceID	proquest gale pubmed crossref
SourceType	Aggregation Database Index Database
StartPage	9309
SubjectTerms	Aged Analysis Animals Apoptosis Bacterial pneumonia Blood clots Cytokines Disease Models, Animal Epigenetic inheritance Female Heterocyclic Compounds, 4 or More Rings - pharmacology Heterocyclic Compounds, 4 or More Rings - therapeutic use Humans Immune response Infections Inflammation Interleukin-6 - metabolism Liver Lung - microbiology Lung - pathology Lungs Male Metabolism Mice Middle Aged Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Neutrophils Pathogens Pathology Patient outcomes Physiological aspects Plasma Pneumonia Pneumonia, Bacterial - drug therapy RNA Sepsis Sirtuin 1 - genetics Sirtuin 1 - metabolism THP-1 Cells
Title	The Sirt1 Activator SRT1720 Mitigates Human Monocyte Activation and Improves Outcome During Gram-Negative Pneumosepsis in Mice
URI	https://www.ncbi.nlm.nih.gov/pubmed/41096578 https://www.proquest.com/docview/3261079030 https://www.proquest.com/docview/3261792984
Volume	26
WOSCitedRecordID	wos001593662300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Health & Medical Collection (ProQuest) customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: 7X7 dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: BENPR dateStart: 20000301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Research library customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: M2O dateStart: 20000301 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1422-0067 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0023259 issn: 1422-0067 databaseCode: PIMPY dateStart: 20000301 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RLUhceD8CpTISiFPUOG-f0AItILHbqC3Scoqy9gQFaZOSZJF64bcz42SXtgcuXCxZdhxLMx5_nz2eAXhFe16JxjduWJiYiih20zLSrox9TSgpDhFtENcvyXyeLhYqGw_cutGtcmMTraE2jeYz8gOCGcRUFOnk2_OfLmeN4tvVMYXGDuxypLJwArvvDufZyZZyBb5NlyZpF3LjSMWD63tARP-g-rHqmD6ogJ0RL21K103zNcBpN56ju_875XtwZ4ScYjroyH24gfUDuDUkobx4CL9JU8Rp1fZSTLVNdta04vTkjDCHJ2aVjcGBnbCn_YJMQKMvetx0JamKojZiOJugbsfrniaH4oN9_ig-tsXKneN3G15cZDWuV3zl0FWdqGg0slKP4OvR4dn7T-6YlcHVxGZ7Nwk0wQZdaK9UktOUFf5SE0-MEkNYxXiqJM5SmlJ6qBUTSq3NMkJfIqaoPBM8hknd1PgUROzLglRF0sBlaPxwqbAoCZCS0VtGKlIOvN6IJT8fgm_kRFpYfPll8TnwhmWW85rs24LmNjwtoL9wdKt8mkZKhfxI14G9Kz1pLemrzRtJ5uNa7vK_YnTg5baZv2T_tBqb9dAnIaSZhg48GbRlO-NQcoSdJH3278Gfw21OZc-eCTLeg0nfrvEF3NS_-qpr92EnWSS2TPdHJafazD-mWvZ5ln37AwI4BQE
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFEQv5U0NBRaJipNVe_3cA0IRpTRqEiIapHIyzu4YGSl2sR1QLv1J_EZm13Foe-DWAxdfdjy219-8dmdnAF6RzctQcWX7qQrpEoR2nAXSdkMuyUsKfURTxHUYjcfx6amYbMDv7iyMTqvsdKJR1KqUeo18n9wMilQEYfLt2Q9bd43Su6tdC40WFse4_EUhW_1mcED_d4_zw_fTd0f2qquALSkaa-zIk2T2ZCqdTLi6zVbKZ5LinCBSZGuVIzLyuTOVuQ5KoQMiKdUsQO4ixigc5RHfG7DpE9jjHmxOBqPJl3WI53HTns0lq2eHgQjbVHvPE85-_n1e63BFeDr58YIRvGoKrji4xtAd3vnfpugubK9catZvZeAebGBxH261TTaXD-CcJIGd5FXjsr40zdzKip18mpJP5bBRbmqMYM3MbgYjFVfKZYMdKaGWpYVi7doLkX1cNDQZyA7M8U72oUrn9hi_mfLpbFLgYq63VOq8ZjlxIy38ED5fy8c_gl5RFrgDLORuSqLgEuPMV9yfCUwzcrhJqc8CEQgL9joYJGdtcZGEgjINl-QiXCx4rTGSaJ3TVCm9W3t0gp6iq3cl_TgQwteHkC3YvURJukJeHu6Qk6x0VZ38hY0FL9fD-k6df1dguWhpIvKkY9-Cxy0612_su7qCUBQ_-TfzF3D7aDoaJsPB-PgpbHHdR9kkRe5Cr6kW-Axuyp9NXlfPV0LF4Ot1g_QPy1ZdnQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8hAX3pRAASNRcYo2cZ4-ILRiWahatitapN7SrD1BqbRJSbKgvfDD-HWM7c3S9sCtBy65eDJJnG9e9ngG4DXZvAIVV26Yq5guUeymRSRdP-aSvKQ4RDRFXPeTySQ9PhbTDfjdn4XRaZW9TjSKWtVSr5EPyM2gSEUQJgfFKi1iOhq_O_vu6g5Seqe1b6dhIbKHy58UvrVvd0f0r3c4H384ev_JXXUYcCVFZp2bBJJMoMylVwhft9zK-UxSzBMliuyu8kRB_nehCt9DKXRwJKWaRch9xBSFpwLiew2uJyEZZZ02yA_WwV7ATaM2n-yfG0citkn3QSC8QXk6b3XgIgKdBnnOHF42CpdcXWPyxnf_58m6B3dWjjYbWsm4DxtYPYCbtvXm8iH8Ivlgh2XT-WwoTYu3umGHX47I0_LY59JUHsGWmT0ORoqvlssOe1LCMssrxeyKDJEdLDqaGGQjc-iTfWzyuTvBb6aoOptWuJjrjZa2bFlJ3Eg3P4KvV_Lxj2Gzqit8Aizmfk4C4hPjIlQ8nAnMC3LDSdXPIhEJB3Z6SGRntuRIRqGahk52HjoOvNF4ybQm6pqc3s0eqKCn6Jpe2TCNhAj10WQHti9QkgaRF4d7FGUrDdZmfyHkwKv1sL5TZ-VVWC8sTUL-dRo6sGWRun7j0Nd1hZL06b-Zv4RbhMxsf3ey9wxuc91c2WRKbsNm1yzwOdyQP7qybV4Y6WJwctUI_QO85GTX
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Sirt1+Activator+SRT1720+Mitigates+Human+Monocyte+Activation+and+Improves+Outcome+During+Gram-Negative+Pneumosepsis+in+Mice&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Blot%2C+Mathieu&rft.au=L%C3%A9opold%2C+Valentine&rft.au=de+Beer%2C+Regina&rft.au=Florquin%2C+Sandrine&rft.date=2025-10-01&rft.issn=1422-0067&rft.eissn=1422-0067&rft.volume=26&rft.issue=19&rft_id=info:doi/10.3390%2Fijms26199309&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon