Cystatin C and creatinine eGFR reference intervals in healthy adults from Cameroon

Several equations are available for estimation of glomerular filtration rates (eGFRs) from serum cystatin C and creatinine, but data on reference intervals from healthy subjects are scarce. Employing nine well-known equations, we calculated eGFRs for healthy Cameroonians, 194 men and 187 women 18-71...

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Vydáno v:SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION Ročník 85; číslo 6; s. 468 - 479
Hlavní autoři: Kågedal, Bertil, Dernroth, Dženeta Nezirević, Edinga-Melenge, Bertille Elodie, Tchapmi, Adrienne Yakam, Nansseu, Jobert Richie, Ama Moor, Vicky Jocelyne, Belinga, Suzanne, Hanberger, Håkan, Helldén, Anders
Médium: Journal Article Publikace
Jazyk:angličtina
Vydáno: England 2025
Témata:
Adolescent
Adult
Aged
Cameroon
Creatinine - blood
cys
Cystatin C - blood
Female
Glomerular Filtration Rate
Healthy Volunteers
Humans
Male
Middle Aged
Reference Values
Young Adult
Cameroon
CAPA
LM-rev
EKFCcrea
EKFCcrea, cys
EKFCcys
reference intervals
eGFRcreatinine
sex differences
eGFRcystatin C
ISSN:0036-5513, 1502-7686, 1502-7686
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Shrnutí:Several equations are available for estimation of glomerular filtration rates (eGFRs) from serum cystatin C and creatinine, but data on reference intervals from healthy subjects are scarce. Employing nine well-known equations, we calculated eGFRs for healthy Cameroonians, 194 men and 187 women 18-71 years of age. Reference intervals were calculated using conventional techniques. For subjects < 50 years of age the eGFR reference intervals were with CAPA (men; women) 70.1-127.1; 79.9-172.2, with CKD-EPI 75.1-131.2; 81.3-135.5, with LM rev 65.4-106.5; 61.4-110.3, with CKD-EPI 74.1-127.2; 67.0-129.8, with mean (LM rev, CAPA) 72.2-110.6; 72.8-136.9, with CKD-EPI 81.1-126.6; 77.0-135.7, with EKFC 85.5-116.3; 83.3-124.8, with EKFC 69.4-114.2; 62.8-114.3, and with EKFC 82.5-114.0: 77.1-116.4 mL/min/1.73 m , respectively. Median eGFR was significantly higher than eGFR irrespective of equations used. The eGFR difference between healthy men and women aged < 50 years may be explained by lower production rates of cystatin C in women. The higher eGFR reference intervals compared to that of eGFR may be caused by increased tubular secretion of creatinine or increased production of cystatin C in the cohorts used for establishing the equations relative the case in healthy subjects. This suggests that the eGFR equations need to be further assessed regarding accuracy to adequately correspond to true GFR.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0036-5513
1502-7686
1502-7686
DOI:10.1080/00365513.2025.2559354