Dynamic ray tracing for modeling optical cell manipulation
Current methods for predicting stress distribution on a cell surface due to optical trapping forces are based on a traditional ray optics scheme for fixed geometries. Cells are typically modeled as solid spheres as this facilitates optical force calculation. Under such applied forces however, real a...
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| Vydané v: | Optics express Ročník 18; číslo 16; s. 16702 - 16714 |
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| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Optical Society of America
02.08.2010
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| ISSN: | 1094-4087, 1094-4087 |
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| Abstract | Current methods for predicting stress distribution on a cell surface due to optical trapping forces are based on a traditional ray optics scheme for fixed geometries. Cells are typically modeled as solid spheres as this facilitates optical force calculation. Under such applied forces however, real and non-rigid cells can deform, so assumptions inherent in traditional ray optics methods begin to break down. In this work, we implement a dynamic ray tracing technique to calculate the stress distribution on a deformable cell induced by optical trapping. Here, cells are modeled as three-dimensional elastic capsules with a discretized surface with associated hydrodynamic forces calculated using the Immersed Boundary Method. We use this approach to simulate the transient deformation of spherical, ellipsoidal and biconcave capsules due to external optical forces induced by a single diode bar optical trap for a range of optical powers. |
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| AbstractList | Current methods for predicting stress distribution on a cell surface due to optical trapping forces are based on a traditional ray optics scheme for fixed geometries. Cells are typically modeled as solid spheres as this facilitates optical force calculation. Under such applied forces however, real and non-rigid cells can deform, so assumptions inherent in traditional ray optics methods begin to break down. In this work, we implement a dynamic ray tracing technique to calculate the stress distribution on a deformable cell induced by optical trapping. Here, cells are modeled as three-dimensional elastic capsules with a discretized surface with associated hydrodynamic forces calculated using the Immersed Boundary Method. We use this approach to simulate the transient deformation of spherical, ellipsoidal and biconcave capsules due to external optical forces induced by a single diode bar optical trap for a range of optical powers. Current methods for predicting stress distribution on a cell surface due to optical trapping forces are based on a traditional ray optics scheme for fixed geometries. Cells are typically modeled as solid spheres as this facilitates optical force calculation. Under such applied forces however, real and non-rigid cells can deform, so assumptions inherent in traditional ray optics methods begin to break down. In this work, we implement a dynamic ray tracing technique to calculate the stress distribution on a deformable cell induced by optical trapping. Here, cells are modeled as three-dimensional elastic capsules with a discretized surface with associated hydrodynamic forces calculated using the Immersed Boundary Method. We use this approach to simulate the transient deformation of spherical, ellipsoidal and biconcave capsules due to external optical forces induced by a single diode bar optical trap for a range of optical powers.Current methods for predicting stress distribution on a cell surface due to optical trapping forces are based on a traditional ray optics scheme for fixed geometries. Cells are typically modeled as solid spheres as this facilitates optical force calculation. Under such applied forces however, real and non-rigid cells can deform, so assumptions inherent in traditional ray optics methods begin to break down. In this work, we implement a dynamic ray tracing technique to calculate the stress distribution on a deformable cell induced by optical trapping. Here, cells are modeled as three-dimensional elastic capsules with a discretized surface with associated hydrodynamic forces calculated using the Immersed Boundary Method. We use this approach to simulate the transient deformation of spherical, ellipsoidal and biconcave capsules due to external optical forces induced by a single diode bar optical trap for a range of optical powers. |
| Author | Szatmary, Alex C. Eggleton, Charles D. Marr, David W. M. Sraj, Ihab |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20721060$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_mi13040608 crossref_primary_10_1088_2040_8986_ad5f9e crossref_primary_10_1016_j_ijheatfluidflow_2015_10_002 crossref_primary_10_1088_2040_8978_17_7_075403 crossref_primary_10_1016_j_piutam_2015_03_007 crossref_primary_10_1088_2040_8986_abb58f crossref_primary_10_1039_C8AN00037A crossref_primary_10_1016_j_ijleo_2020_165479 crossref_primary_10_1063_1_4906092 |
| Cites_doi | 10.1016/j.tibtech.2007.01.005 10.1016/S0006-3495(99)77279-6 10.1016/j.actbio.2004.09.001 10.1016/S0021-9290(99)00175-X 10.1021/la00048a037 10.1103/PhysRevLett.94.098103 10.1088/0957-4484/4/2/006 10.1016/S0006-3495(95)80084-6 10.1016/0021-9991(89)90213-1 10.1016/S0006-3495(01)75740-2 10.1016/0026-2862(72)90069-6 10.1103/PhysRevLett.24.156 10.1364/OE.14.012503 10.1364/OE.16.001996 10.1080/10867651.1997.10487468 10.1016/S0006-3495(92)81860-X 10.1017/S002211200400062X 10.1073/pnas.0703433104 10.1152/ajpheart.91536.2007 10.1080/2151237X.2005.10129195 10.1182/blood.V92.8.2975 10.1529/biophysj.104.045476 10.1063/1.869703 10.1103/PhysRevLett.84.5451 10.1063/1.870349 10.1063/1.2829589 10.1115/1.2112907 |
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| SubjectTerms | Animals Cells Computer Simulation Hydrodynamics Micromanipulation - methods Models, Biological Optical Tweezers Skates (Fish) Stress, Mechanical |
| Title | Dynamic ray tracing for modeling optical cell manipulation |
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