Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism

The transcriptional regulation of several dozen genes in response to low oxygen tension is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1alpha and HIF-1beta. In the HIF-1alpha-deficient human leukemic cell line, Z-33, exposed to mild (8% O(2))...

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Vydané v:	Journal of cell science Ročník 117; číslo Pt 9; s. 1785
Hlavní autori:	Wellmann, Sven, Bührer, Christoph, Moderegger, Eva, Zelmer, Andrea, Kirschner, Renate, Koehne, Petra, Fujita, Jun, Seeger, Karl
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.04.2004
Predmet:	Animals Antioxidants - pharmacology Aryl Hydrocarbon Receptor Nuclear Translocator Burkitt Lymphoma - genetics Burkitt Lymphoma - metabolism Carcinoma, Hepatocellular - genetics Cell Hypoxia - drug effects Cell Hypoxia - genetics Cell Hypoxia - physiology Cell Line, Tumor Cyanides - pharmacology Dactinomycin - pharmacology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Profiling Gene Expression Regulation - drug effects Humans Hypothermia - genetics Hypoxia-Inducible Factor 1, alpha Subunit Mice Mitochondria - drug effects Mitochondria - metabolism Oxidation-Reduction - drug effects Oxygen - pharmacology Receptors, Aryl Hydrocarbon - deficiency Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics Sodium Azide - pharmacology Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation - drug effects
ISSN:	0021-9533
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