Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease

The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 contro...

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Published in:	Scientific reports Vol. 7; no. 1; p. 39918
Main Authors:	Zhao, Zhenzhou, Li, Xuejie, Gao, Chuanyu, Jian, Dongdong, Hao, Peiyuan, Rao, Lixin, Li, Muwei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.01.2017 Nature Publishing Group
Subjects:	38/77 45/61 692/4019/592/2727 692/53/2421 Adult Aged Area Under Curve Biomarkers Biomarkers - blood Cardiovascular disease Case-Control Studies Circular RNA Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary vessels DNA microarrays Heart diseases Humanities and Social Sciences Humans Middle Aged multidisciplinary Oligonucleotide Array Sequence Analysis Peripheral blood Risk Factors RNA - blood ROC Curve Science Science (multidisciplinary) Sensitivity and Specificity Transcriptome
ISSN:	2045-2322, 2045-2322
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Abstract	The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710–0.827], P < 0.001) to 0.804 ([0.751–0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.
AbstractList	The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710–0.827], P < 0.001) to 0.804 ([0.751–0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.
ArticleNumber	39918
Author	Gao, Chuanyu Zhao, Zhenzhou Jian, Dongdong Hao, Peiyuan Rao, Lixin Li, Xuejie Li, Muwei
Author_xml	– sequence: 1 givenname: Zhenzhou surname: Zhao fullname: Zhao, Zhenzhou organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 2 givenname: Xuejie surname: Li fullname: Li, Xuejie organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 3 givenname: Chuanyu surname: Gao fullname: Gao, Chuanyu organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 4 givenname: Dongdong surname: Jian fullname: Jian, Dongdong organization: Department of Cardiology, The First Affiliated Hospital of Zhejiang University, Zhejiang University – sequence: 5 givenname: Peiyuan surname: Hao fullname: Hao, Peiyuan organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 6 givenname: Lixin surname: Rao fullname: Rao, Lixin organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 7 givenname: Muwei surname: Li fullname: Li, Muwei email: limuwei@medmail.com.cn organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University
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Cites_doi	10.1371/journal.pgen.1001233 10.1016/j.molcel.2014.08.019 10.1016/S0140-6736(14)61682-2 10.1182/blood-2008-12-193326 10.1371/journal.pgen.1003777 10.1038/cr.2015.82 10.1016/j.avsg.2014.07.026 10.1007/s001250050900 10.7554/eLife.07540 10.1038/nature11993 10.1038/nature05911 10.3233/CBM-150552 10.1161/01.CIR.99.17.2345 10.1016/j.athoracsur.2015.10.051 10.1186/1471-2261-13-12 10.1006/jmcc.2001.1419 10.1038/nsmb.2959 10.1038/nature11928 10.1161/CIRCULATIONAHA.114.011541 10.1016/j.cca.2015.02.018 10.1261/rna.035667.112 10.1038/29788 10.1038/srep08057 10.1161/01.CIR.0000125526.91945.AE 10.1016/j.cell.2014.03.008 10.1093/eurheartj/ehq167 10.1161/01.CIR.95.7.1760 10.1016/j.cell.2015.02.014 10.3389/fgene.2015.00175 10.1038/nn.3975 10.1042/CS20150121 10.1074/jbc.M510579200 10.1161/CIRCIMAGING.115.003533 10.18632/oncotarget.3469
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References	Li (CR6) 2015; 22 Barrett, Wang, Salzman (CR5) 2015; 4 Scanlon (CR24) 1999; 99 Li (CR32) 2006; 281 Salzman, Chen, Olsen, Wang, Brown (CR13) 2013; 9 Bachmayr-Heyda (CR16) 2015; 5 Ashwal-Fluss (CR11) 2014; 56 Burd (CR17) 2010; 6 Lukiw (CR18) 2013; 4 You (CR12) 2015; 18 Choy, Granville, Hunt, McManus (CR29) 2001; 33 Boring, Gosling, Cleary, Charo (CR35) 1998; 394 Jiang, Tian, Wang, Chen, Du (CR37) 2014; 30 Cech, Steitz (CR4) 2014; 157 Li (CR20) 2015; 6 Waldo (CR3) 2014; 130 Hitchner (CR25) 2015; 29 Zhang (CR34) 2009; 114 Burton (CR22) 2007; 447 Sianos (CR23) 2005; 1 Memczak (CR8) 2013; 495 Gidlof (CR28) 2013; 13 Hansen (CR9) 2013; 495 Li (CR14) 2015; 25 Lin, Lo, Wong, Xiao (CR15) 2015; 6 Acharya (CR2) 2016; 101 Ghadrdoost, Haghjoo, Firouzi (CR36) 2015; 4 Luo, Zhao, Cao, Ye, Li (CR38) 2007; 32 Arbab-Zadeh (CR39) 2015; 8 Hutter (CR33) 2004; 109 Naghavi (CR1) 2015; 385 Qin (CR21) 2016; 16 Yang (CR26) 2015; 129 D’Alessandra (CR27) 2010; 31 Dimmeler, Haendeler, Galle, Zeiher (CR31) 1997; 95 Du (CR30) 1998; 41 Li (CR19) 2015; 444 Conn (CR10) 2015; 160 Jeck (CR7) 2013; 19 G Sianos (BFsrep39918_CR23) 2005; 1 O Gidlof (BFsrep39918_CR28) 2013; 13 S Dimmeler (BFsrep39918_CR31) 1997; 95 X Lin (BFsrep39918_CR15) 2015; 6 Y Li (BFsrep39918_CR32) 2006; 281 E Hitchner (BFsrep39918_CR25) 2015; 29 R Hutter (BFsrep39918_CR33) 2004; 109 L Luo (BFsrep39918_CR38) 2007; 32 SJ Conn (BFsrep39918_CR10) 2015; 160 P Li (BFsrep39918_CR19) 2015; 444 WR Jeck (BFsrep39918_CR7) 2013; 19 Z Li (BFsrep39918_CR6) 2015; 22 A Arbab-Zadeh (BFsrep39918_CR39) 2015; 8 PR Burton (BFsrep39918_CR22) 2007; 447 CE Burd (BFsrep39918_CR17) 2010; 6 TB Hansen (BFsrep39918_CR9) 2013; 495 PJ Scanlon (BFsrep39918_CR24) 1999; 99 TR Cech (BFsrep39918_CR4) 2014; 157 B Zhang (BFsrep39918_CR34) 2009; 114 XL Du (BFsrep39918_CR30) 1998; 41 Y Jiang (BFsrep39918_CR37) 2014; 30 D Acharya (BFsrep39918_CR2) 2016; 101 Y Li (BFsrep39918_CR14) 2015; 25 R Ashwal-Fluss (BFsrep39918_CR11) 2014; 56 Y Yang (BFsrep39918_CR26) 2015; 129 X You (BFsrep39918_CR12) 2015; 18 Y D’Alessandra (BFsrep39918_CR27) 2010; 31 M Qin (BFsrep39918_CR21) 2016; 16 B Ghadrdoost (BFsrep39918_CR36) 2015; 4 JC Choy (BFsrep39918_CR29) 2001; 33 SP Barrett (BFsrep39918_CR5) 2015; 4 S Memczak (BFsrep39918_CR8) 2013; 495 J Salzman (BFsrep39918_CR13) 2013; 9 SW Waldo (BFsrep39918_CR3) 2014; 130 A Bachmayr-Heyda (BFsrep39918_CR16) 2015; 5 L Boring (BFsrep39918_CR35) 1998; 394 F Li (BFsrep39918_CR20) 2015; 6 M Naghavi (BFsrep39918_CR1) 2015; 385 WJ Lukiw (BFsrep39918_CR18) 2013; 4 21151960 - PLoS Genet. 2010 Dec 02;6(12):e1001233 20534597 - Eur Heart J. 2010 Nov;31(22):2765-73 26467105 - Circ Cardiovasc Imaging. 2015 Oct;8(10):e003533 17554300 - Nature. 2007 Jun 7;447(7145):661-78 15078795 - Circulation. 2004 Apr 27;109(16):2001-8 25785254 - Res Cardiovasc Med. 2015 Feb 20;4(1):e25547 24427167 - Front Genet. 2013 Dec 31;4:307 24039610 - PLoS Genet. 2013;9(9):e1003777 23249747 - RNA. 2013 Feb;19(2):141-57 26718859 - Ann Thorac Surg. 2016 Feb;101(2):558-66 11549346 - J Mol Cell Cardiol. 2001 Sep;33(9):1673-90 25664725 - Nat Struct Mol Biol. 2015 Mar;22(3):256-64 26138677 - Cell Res. 2015 Aug;25(8):981-4 23446348 - Nature. 2013 Mar 21;495(7441):333-8 19758907 - EuroIntervention. 2005 Aug;1(2):219-27 9732872 - Nature. 1998 Aug 27;394(6696):894-7 25689795 - Clin Chim Acta. 2015 Apr 15;444:132-6 25999984 - Front Genet. 2015 May 07;6:175 24679528 - Cell. 2014 Mar 27;157(1):77-94 19741192 - Blood. 2009 Nov 5;114(19):4300-9 25530442 - Lancet. 2015 Jan 10;385(9963):117-71 17478942 - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Apr;32(2):309-11 25391519 - Circulation. 2014 Dec 23;130(25):2295-301 16380374 - J Biol Chem. 2006 Mar 10;281(10 ):6707-17 9541163 - Diabetologia. 1998 Mar;41(3):249-56 25674134 - Pak J Med Sci. 2014 Nov-Dec;30(6):1331-5 25749389 - Oncotarget. 2015 Mar 20;6(8):6001-13 10226103 - Circulation. 1999 May 4;99(17 ):2345-57 25624062 - Sci Rep. 2015 Jan 27;5:8057 25242144 - Mol Cell. 2014 Oct 2;56(1):55-66 26057830 - Elife. 2015 Jun 09;4:e07540 9107159 - Circulation. 1997 Apr 1;95(7):1760-3 26201019 - Clin Sci (Lond). 2015 Oct 1;129(8):675-85 23446346 - Nature. 2013 Mar 21;495(7441):384-8 25768908 - Cell. 2015 Mar 12;160(6):1125-34 25194552 - Ann Vasc Surg. 2015 Jan;29(1):28-33 25714049 - Nat Neurosci. 2015 Apr;18(4):603-10 26600397 - Cancer Biomark. 2016;16(1):161-9 23448306 - BMC Cardiovasc Disord. 2013 Feb 28;13:12
References_xml	– volume: 6 start-page: e1001233 year: 2010 ident: CR17 article-title: Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001233 – volume: 56 start-page: 55 year: 2014 end-page: 66 ident: CR11 article-title: circRNA biogenesis competes with pre-mRNA splicing publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.08.019 – volume: 6 start-page: 6001 year: 2015 end-page: 6013 ident: CR20 article-title: Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway publication-title: Oncotarget – volume: 385 start-page: 117 year: 2015 end-page: 171 ident: CR1 article-title: Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 publication-title: Lancet doi: 10.1016/S0140-6736(14)61682-2 – volume: 4 start-page: e25547 year: 2015 ident: CR36 article-title: Accuracy of cardiogoniometry compared with electrocardiography in the diagnosis of coronary artery disease publication-title: Res Cardiovasc Med. – volume: 114 start-page: 4300 year: 2009 end-page: 4309 ident: CR34 article-title: Repulsive axon guidance molecule Slit3 is a novel angiogenic factor publication-title: Blood doi: 10.1182/blood-2008-12-193326 – volume: 9 start-page: e1003777 year: 2013 ident: CR13 article-title: Cell-type specific features of circular RNA expression publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003777 – volume: 25 start-page: 981 year: 2015 end-page: 984 ident: CR14 article-title: Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis publication-title: Cell Res. doi: 10.1038/cr.2015.82 – volume: 4 start-page: 307 year: 2013 ident: CR18 article-title: Circular RNA (circRNA) in Alzheimer’s disease (AD) publication-title: Front. Genet. – volume: 29 start-page: 28 year: 2015 end-page: 33 ident: CR25 article-title: A prospective evaluation of using IVUS during percutaneous superficial femoral artery interventions publication-title: Ann. Vasc. Surg. doi: 10.1016/j.avsg.2014.07.026 – volume: 41 start-page: 249 year: 1998 end-page: 256 ident: CR30 article-title: Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species publication-title: Diabetologia doi: 10.1007/s001250050900 – volume: 1 start-page: 219 year: 2005 end-page: 227 ident: CR23 article-title: The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease publication-title: EuroIntervention – volume: 4 start-page: e07540 year: 2015 ident: CR5 article-title: Circular RNA biogenesis can proceed through an exon-containing lariat precursor publication-title: Elife doi: 10.7554/eLife.07540 – volume: 495 start-page: 384 year: 2013 end-page: 388 ident: CR9 article-title: Natural RNA circles function as efficient microRNA sponges publication-title: Nature doi: 10.1038/nature11993 – volume: 447 start-page: 661 year: 2007 end-page: 678 ident: CR22 article-title: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls publication-title: Nature doi: 10.1038/nature05911 – volume: 16 start-page: 161 year: 2016 end-page: 169 ident: CR21 article-title: Hsa_circ_0001649: a circular RNA and potential novel biomarker for hepatocellular carcinoma publication-title: Cancer Biomark. doi: 10.3233/CBM-150552 – volume: 99 start-page: 2345 year: 1999 end-page: 2357 ident: CR24 article-title: ACC/AHA guidelines for coronary angiography: executive summary and recommendations A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Coronary Angiography) developed in collaboration with the Society for Cardiac Angiography and Interventions publication-title: Circulation doi: 10.1161/01.CIR.99.17.2345 – volume: 8 start-page: e003533 year: 2015 ident: CR39 article-title: Accuracy of Computed Tomographic Angiography and Single-Photon Emission Computed Tomography-Acquired Myocardial Perfusion Imaging for the Diagnosis of Coronary Artery Disease publication-title: Circ. Cardiovasc Imaging. – volume: 101 start-page: 558 year: 2016 end-page: 566 ident: CR2 article-title: Clinical characteristics and outcomes of patients with myocardial infarction and cardiogenic shock undergoing coronary artery bypass surgery: data from the Society of Thoracic Surgeons National Database publication-title: Ann. Thorac. Surg. doi: 10.1016/j.athoracsur.2015.10.051 – volume: 13 start-page: 12 year: 2013 ident: CR28 article-title: Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction publication-title: BMC Cardiovasc. Disord. doi: 10.1186/1471-2261-13-12 – volume: 33 start-page: 1673 year: 2001 end-page: 1690 ident: CR29 article-title: Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis publication-title: J. Mol. Cell. Cardiol. doi: 10.1006/jmcc.2001.1419 – volume: 22 start-page: 256 year: 2015 end-page: 264 ident: CR6 article-title: Exon-intron circular RNAs regulate transcription in the nucleus publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2959 – volume: 495 start-page: 333 year: 2013 end-page: 338 ident: CR8 article-title: Circular RNAs are a large class of animal RNAs with regulatory potency publication-title: Nature doi: 10.1038/nature11928 – volume: 130 start-page: 2295 year: 2014 end-page: 2301 ident: CR3 article-title: Surgical ineligibility and mortality among patients with unprotected left main or multivessel coronary artery disease undergoing percutaneous coronary intervention publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.114.011541 – volume: 30 start-page: 1331 year: 2014 end-page: 1335 ident: CR37 article-title: Diagnostic value of combined parameters derived from ambulatory electrocardiography for detecting coronary artery disease in non-active chest pain patients publication-title: Pak J Med Sci. – volume: 444 start-page: 132 year: 2015 end-page: 136 ident: CR19 article-title: Using circular RNA as a novel type of biomarker in the screening of gastric cancer publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2015.02.018 – volume: 19 start-page: 141 year: 2013 end-page: 157 ident: CR7 article-title: Circular RNAs are abundant, conserved, and associated with ALU repeats publication-title: RNA doi: 10.1261/rna.035667.112 – volume: 394 start-page: 894 year: 1998 end-page: 897 ident: CR35 article-title: Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis publication-title: Nature doi: 10.1038/29788 – volume: 5 start-page: 8057 year: 2015 ident: CR16 article-title: Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues publication-title: Sci. Rep. doi: 10.1038/srep08057 – volume: 109 start-page: 2001 year: 2004 end-page: 2008 ident: CR33 article-title: Caspase-3 and tissue factor expression in lipid-rich plaque macrophages: evidence for apoptosis as link between inflammation and atherothrombosis publication-title: Circulation doi: 10.1161/01.CIR.0000125526.91945.AE – volume: 157 start-page: 77 year: 2014 end-page: 94 ident: CR4 article-title: The noncoding RNA revolution-trashing old rules to forge new ones publication-title: Cell doi: 10.1016/j.cell.2014.03.008 – volume: 31 start-page: 2765 year: 2010 end-page: 2773 ident: CR27 article-title: Circulating microRNAs are new and sensitive biomarkers of myocardial infarction publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehq167 – volume: 95 start-page: 1760 year: 1997 end-page: 1763 ident: CR31 article-title: Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the ‘response to injury’ hypothesis publication-title: Circulation doi: 10.1161/01.CIR.95.7.1760 – volume: 160 start-page: 1125 year: 2015 end-page: 1134 ident: CR10 article-title: The RNA binding protein quaking regulates formation of circRNAs publication-title: Cell doi: 10.1016/j.cell.2015.02.014 – volume: 6 start-page: 175 year: 2015 ident: CR15 article-title: Noncoding RNAs in human saliva as potential disease biomarkers publication-title: Front. Genet. doi: 10.3389/fgene.2015.00175 – volume: 18 start-page: 603 year: 2015 end-page: 610 ident: CR12 article-title: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity publication-title: Nat. Neurosci. doi: 10.1038/nn.3975 – volume: 129 start-page: 675 year: 2015 end-page: 685 ident: CR26 article-title: Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease publication-title: Clin. Sci. doi: 10.1042/CS20150121 – volume: 281 start-page: 6707 year: 2006 end-page: 6717 ident: CR32 article-title: Cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the Mer receptor publication-title: J. Biol. Chem. doi: 10.1074/jbc.M510579200 – volume: 32 start-page: 309 year: 2007 end-page: 311 ident: CR38 article-title: [Diagnostic value of chronotropic incompetence in coronary heart disease] publication-title: J Centr South Univ Med Sci. – volume: 385 start-page: 117 year: 2015 ident: BFsrep39918_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(14)61682-2 – volume: 29 start-page: 28 year: 2015 ident: BFsrep39918_CR25 publication-title: Ann. Vasc. Surg. doi: 10.1016/j.avsg.2014.07.026 – volume: 5 start-page: 8057 year: 2015 ident: BFsrep39918_CR16 publication-title: Sci. Rep. doi: 10.1038/srep08057 – volume: 99 start-page: 2345 year: 1999 ident: BFsrep39918_CR24 publication-title: Circulation doi: 10.1161/01.CIR.99.17.2345 – volume: 4 start-page: 307 year: 2013 ident: BFsrep39918_CR18 publication-title: Front. Genet. – volume: 8 start-page: e003533 year: 2015 ident: BFsrep39918_CR39 publication-title: Circ. Cardiovasc Imaging. doi: 10.1161/CIRCIMAGING.115.003533 – volume: 4 start-page: e25547 year: 2015 ident: BFsrep39918_CR36 publication-title: Res Cardiovasc Med. – volume: 281 start-page: 6707 year: 2006 ident: BFsrep39918_CR32 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M510579200 – volume: 157 start-page: 77 year: 2014 ident: BFsrep39918_CR4 publication-title: Cell doi: 10.1016/j.cell.2014.03.008 – volume: 19 start-page: 141 year: 2013 ident: BFsrep39918_CR7 publication-title: RNA doi: 10.1261/rna.035667.112 – volume: 4 start-page: e07540 year: 2015 ident: BFsrep39918_CR5 publication-title: Elife doi: 10.7554/eLife.07540 – volume: 1 start-page: 219 year: 2005 ident: BFsrep39918_CR23 publication-title: EuroIntervention – volume: 9 start-page: e1003777 year: 2013 ident: BFsrep39918_CR13 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003777 – volume: 447 start-page: 661 year: 2007 ident: BFsrep39918_CR22 publication-title: Nature doi: 10.1038/nature05911 – volume: 32 start-page: 309 year: 2007 ident: BFsrep39918_CR38 publication-title: J Centr South Univ Med Sci. – volume: 16 start-page: 161 year: 2016 ident: BFsrep39918_CR21 publication-title: Cancer Biomark. doi: 10.3233/CBM-150552 – volume: 95 start-page: 1760 year: 1997 ident: BFsrep39918_CR31 publication-title: Circulation doi: 10.1161/01.CIR.95.7.1760 – volume: 130 start-page: 2295 year: 2014 ident: BFsrep39918_CR3 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.114.011541 – volume: 13 start-page: 12 year: 2013 ident: BFsrep39918_CR28 publication-title: BMC Cardiovasc. Disord. doi: 10.1186/1471-2261-13-12 – volume: 25 start-page: 981 year: 2015 ident: BFsrep39918_CR14 publication-title: Cell Res. doi: 10.1038/cr.2015.82 – volume: 101 start-page: 558 year: 2016 ident: BFsrep39918_CR2 publication-title: Ann. Thorac. Surg. doi: 10.1016/j.athoracsur.2015.10.051 – volume: 109 start-page: 2001 year: 2004 ident: BFsrep39918_CR33 publication-title: Circulation doi: 10.1161/01.CIR.0000125526.91945.AE – volume: 56 start-page: 55 year: 2014 ident: BFsrep39918_CR11 publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.08.019 – volume: 41 start-page: 249 year: 1998 ident: BFsrep39918_CR30 publication-title: Diabetologia doi: 10.1007/s001250050900 – volume: 18 start-page: 603 year: 2015 ident: BFsrep39918_CR12 publication-title: Nat. Neurosci. doi: 10.1038/nn.3975 – volume: 160 start-page: 1125 year: 2015 ident: BFsrep39918_CR10 publication-title: Cell doi: 10.1016/j.cell.2015.02.014 – volume: 6 start-page: 175 year: 2015 ident: BFsrep39918_CR15 publication-title: Front. Genet. doi: 10.3389/fgene.2015.00175 – volume: 33 start-page: 1673 year: 2001 ident: BFsrep39918_CR29 publication-title: J. Mol. Cell. Cardiol. doi: 10.1006/jmcc.2001.1419 – volume: 30 start-page: 1331 year: 2014 ident: BFsrep39918_CR37 publication-title: Pak J Med Sci. – volume: 6 start-page: 6001 year: 2015 ident: BFsrep39918_CR20 publication-title: Oncotarget doi: 10.18632/oncotarget.3469 – volume: 22 start-page: 256 year: 2015 ident: BFsrep39918_CR6 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb.2959 – volume: 444 start-page: 132 year: 2015 ident: BFsrep39918_CR19 publication-title: Clin. Chim. Acta doi: 10.1016/j.cca.2015.02.018 – volume: 6 start-page: e1001233 year: 2010 ident: BFsrep39918_CR17 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001233 – volume: 394 start-page: 894 year: 1998 ident: BFsrep39918_CR35 publication-title: Nature doi: 10.1038/29788 – volume: 495 start-page: 333 year: 2013 ident: BFsrep39918_CR8 publication-title: Nature doi: 10.1038/nature11928 – volume: 31 start-page: 2765 year: 2010 ident: BFsrep39918_CR27 publication-title: Eur. Heart J. doi: 10.1093/eurheartj/ehq167 – volume: 495 start-page: 384 year: 2013 ident: BFsrep39918_CR9 publication-title: Nature doi: 10.1038/nature11993 – volume: 129 start-page: 675 year: 2015 ident: BFsrep39918_CR26 publication-title: Clin. Sci. doi: 10.1042/CS20150121 – volume: 114 start-page: 4300 year: 2009 ident: BFsrep39918_CR34 publication-title: Blood doi: 10.1182/blood-2008-12-193326 – reference: 25999984 - Front Genet. 2015 May 07;6:175 – reference: 21151960 - PLoS Genet. 2010 Dec 02;6(12):e1001233 – reference: 25689795 - Clin Chim Acta. 2015 Apr 15;444:132-6 – reference: 15078795 - Circulation. 2004 Apr 27;109(16):2001-8 – reference: 25194552 - Ann Vasc Surg. 2015 Jan;29(1):28-33 – reference: 25391519 - Circulation. 2014 Dec 23;130(25):2295-301 – reference: 17554300 - Nature. 2007 Jun 7;447(7145):661-78 – reference: 9732872 - Nature. 1998 Aug 27;394(6696):894-7 – reference: 25768908 - Cell. 2015 Mar 12;160(6):1125-34 – reference: 23249747 - RNA. 2013 Feb;19(2):141-57 – reference: 25664725 - Nat Struct Mol Biol. 2015 Mar;22(3):256-64 – reference: 10226103 - Circulation. 1999 May 4;99(17 ):2345-57 – reference: 26138677 - Cell Res. 2015 Aug;25(8):981-4 – reference: 26600397 - Cancer Biomark. 2016;16(1):161-9 – reference: 24039610 - PLoS Genet. 2013;9(9):e1003777 – reference: 26718859 - Ann Thorac Surg. 2016 Feb;101(2):558-66 – reference: 25624062 - Sci Rep. 2015 Jan 27;5:8057 – reference: 26201019 - Clin Sci (Lond). 2015 Oct 1;129(8):675-85 – reference: 24679528 - Cell. 2014 Mar 27;157(1):77-94 – reference: 25749389 - Oncotarget. 2015 Mar 20;6(8):6001-13 – reference: 23446348 - Nature. 2013 Mar 21;495(7441):333-8 – reference: 25714049 - Nat Neurosci. 2015 Apr;18(4):603-10 – reference: 26057830 - Elife. 2015 Jun 09;4:e07540 – reference: 9541163 - Diabetologia. 1998 Mar;41(3):249-56 – reference: 23448306 - BMC Cardiovasc Disord. 2013 Feb 28;13:12 – reference: 23446346 - Nature. 2013 Mar 21;495(7441):384-8 – reference: 26467105 - Circ Cardiovasc Imaging. 2015 Oct;8(10):e003533 – reference: 19741192 - Blood. 2009 Nov 5;114(19):4300-9 – reference: 16380374 - J Biol Chem. 2006 Mar 10;281(10 ):6707-17 – reference: 25674134 - Pak J Med Sci. 2014 Nov-Dec;30(6):1331-5 – reference: 11549346 - J Mol Cell Cardiol. 2001 Sep;33(9):1673-90 – reference: 17478942 - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Apr;32(2):309-11 – reference: 20534597 - Eur Heart J. 2010 Nov;31(22):2765-73 – reference: 24427167 - Front Genet. 2013 Dec 31;4:307 – reference: 25242144 - Mol Cell. 2014 Oct 2;56(1):55-66 – reference: 25530442 - Lancet. 2015 Jan 10;385(9963):117-71 – reference: 9107159 - Circulation. 1997 Apr 1;95(7):1760-3 – reference: 25785254 - Res Cardiovasc Med. 2015 Feb 20;4(1):e25547 – reference: 19758907 - EuroIntervention. 2005 Aug;1(2):219-27
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Snippet	The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients...
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SubjectTerms	38/77 45/61 692/4019/592/2727 692/53/2421 Adult Aged Area Under Curve Biomarkers Biomarkers - blood Cardiovascular disease Case-Control Studies Circular RNA Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary vessels DNA microarrays Heart diseases Humanities and Social Sciences Humans Middle Aged multidisciplinary Oligonucleotide Array Sequence Analysis Peripheral blood Risk Factors RNA - blood ROC Curve Science Science (multidisciplinary) Sensitivity and Specificity Transcriptome
Title	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease
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