Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease

The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 contro...

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Vydáno v:	Scientific reports Ročník 7; číslo 1; s. 39918
Hlavní autoři:	Zhao, Zhenzhou, Li, Xuejie, Gao, Chuanyu, Jian, Dongdong, Hao, Peiyuan, Rao, Lixin, Li, Muwei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 03.01.2017 Nature Publishing Group
Témata:	38/77 45/61 692/4019/592/2727 692/53/2421 Adult Aged Area Under Curve Biomarkers Biomarkers - blood Cardiovascular disease Case-Control Studies Circular RNA Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary vessels DNA microarrays Heart diseases Humanities and Social Sciences Humans Middle Aged multidisciplinary Oligonucleotide Array Sequence Analysis Peripheral blood Risk Factors RNA - blood ROC Curve Science Science (multidisciplinary) Sensitivity and Specificity Transcriptome
ISSN:	2045-2322, 2045-2322
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Abstract	The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710–0.827], P < 0.001) to 0.804 ([0.751–0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.
AbstractList	The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710–0.827], P < 0.001) to 0.804 ([0.751–0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients and the potential use of circRNAs as diagnostic biomarkers of CAD. We first analysed peripheral blood circRNAs of 12 CAD patients and 12 control individuals by RNA microarray and found that 22 circRNAs were differentially expressed between these two groups: 12 were upregulated, and 10 were downregulated. Then, we selected 5 circRNAs as candidate biomarkers under stricter screening criteria and verified them in another group of subjects consisting of 30 control individuals and 30 CAD patients with different SYNTAX scores. These 5 circRNAs were all remarkably increased in the CAD group. Hsa_circ_0124644 had the largest area under the curve (AUC). We tested hsa_circ_0124644 in an independent cohort consisting of 115 control individuals and 137 CAD patients. After we included the risk factors for CAD, the AUC slightly increased from 0.769 (95% confidence interval = [0.710-0.827], P < 0.001) to 0.804 ([0.751-0.857], P < 0.001), and when combined with hsa_circ_0098964, the diagnostic value slightly increased. Taken together, our results suggest that hsa_circ_0124644 can be used as a diagnostic biomarker of CAD.
ArticleNumber	39918
Author	Gao, Chuanyu Zhao, Zhenzhou Jian, Dongdong Hao, Peiyuan Rao, Lixin Li, Xuejie Li, Muwei
Author_xml	– sequence: 1 givenname: Zhenzhou surname: Zhao fullname: Zhao, Zhenzhou organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 2 givenname: Xuejie surname: Li fullname: Li, Xuejie organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 3 givenname: Chuanyu surname: Gao fullname: Gao, Chuanyu organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 4 givenname: Dongdong surname: Jian fullname: Jian, Dongdong organization: Department of Cardiology, The First Affiliated Hospital of Zhejiang University, Zhejiang University – sequence: 5 givenname: Peiyuan surname: Hao fullname: Hao, Peiyuan organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 6 givenname: Lixin surname: Rao fullname: Rao, Lixin organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University – sequence: 7 givenname: Muwei surname: Li fullname: Li, Muwei email: limuwei@medmail.com.cn organization: Department of Cardiology, People’s Hospital of Zhengzhou University, Zhengzhou University
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Snippet	The aim of the present study was to investigate the expression of circular RNAs (circRNAs) in the peripheral blood of coronary artery disease (CAD) patients...
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SubjectTerms	38/77 45/61 692/4019/592/2727 692/53/2421 Adult Aged Area Under Curve Biomarkers Biomarkers - blood Cardiovascular disease Case-Control Studies Circular RNA Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary vessels DNA microarrays Heart diseases Humanities and Social Sciences Humans Middle Aged multidisciplinary Oligonucleotide Array Sequence Analysis Peripheral blood Risk Factors RNA - blood ROC Curve Science Science (multidisciplinary) Sensitivity and Specificity Transcriptome
Title	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease
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