Gut Permeability and Microbiota in Parkinson’s Disease: Mechanistic Insights and Experimental Therapeutic Strategies

Globally, Parkinson’s disease (PD) is the neurodegenerative condition with the most rapidly increasing prevalence, and a growing body of evidence associates its pathology with impairments in the gut–brain axis. Traditionally viewed as a disease marked by the loss of dopaminergic neurons, emerging ev...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 26; no. 19; p. 9593
Main Authors:	Liang, Yicheng, Zhao, Yuhang, Fasano, Alessio, Su, Chien-Wen
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.10.2025
Subjects:	alpha-Synuclein - metabolism Animals Blood-Brain Barrier - metabolism Celiac disease Cytokines Development and progression Fatty acids Gastrointestinal Microbiome - physiology Gluten Gut microbiota Health aspects Homeostasis Humans Hypotheses Inflammation Kinases Metabolites Microbiota (Symbiotic organisms) Neurodegeneration Neurons Parkinson Disease - metabolism Parkinson Disease - microbiology Parkinson Disease - therapy Parkinson's disease Pathogens Pathology Patients Peptides Permeability Proteins Stem cells Toxins Type 2 diabetes Massachusetts gut permeability neuroinflammation Parkinson’s disease (PD) leaky gut therapeutic approaches gut microbiota personalized therapy
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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