A Novel Regulatory Role for RPS4Y1 in Inflammatory and Fibrotic Processes

Asthma is a chronic inflammatory respiratory disease well-known to demonstrate sexual dimorphism in incidence and severity, although the mechanisms causing these differences remain incompletely understood. RPS4X and RPS4Y1 are X and Y-chromosome-linked genes coding ribosomal subunits previously asso...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 26; no. 13; p. 6213
Main Authors:	Reddy, Karosham D., Rathnayake, Senani N. H., Idrees, Sobia, Boedijono, Fia, Xenaki, Dikaia, Padula, Matthew P., Berge, Maarten van den, Faiz, Alen, Oliver, Brian G. G.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.07.2025
Subjects:	Amino acids Analysis Animals Asthma Asthma - genetics Asthma - metabolism Asthma - pathology Cell cycle Cell growth CRISPR-Cas Systems Cytokines Disease Enzymes Extracellular matrix Female Females Fibrosis Gene expression Genes Genetic aspects Genetic translation Genomes Humans Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Interleukin-6 - genetics Interleukin-6 - metabolism Male Males Medical prognosis Medical research Medicine, Experimental Proteins Respiratory agents Ribonucleic acid Ribosomal Proteins - genetics Ribosomal Proteins - metabolism RNA Tenascin - genetics Tenascin - metabolism X chromosomes Y chromosomes United States Massachusetts Germany RNA-seq inflammation CRISPR-Cas9 Y-chromosome asthma fibrosis sex differences
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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