Acute compressive stress activates RHO/ROCK-mediated cellular processes

The ability to rapidly respond to applied force underpins cell/tissue homeostasis. This response is mediated by mechanotransduction pathways that regulate remodeling and tension of the actomyosin cytoskeleton to counterbalance external forces. Enhanced extracellular matrix tension hyper-activates me...

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Bibliographic Details
Published in:	Small GTPases Vol. 11; no. 5; pp. 354 - 370
Main Authors:	Boyle, Sarah T., Kular, Jasreen, Nobis, Max, Ruszkiewicz, Andrew, Timpson, Paul, Samuel, Michael S.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02.09.2020
Subjects:	actomyosin tension compressive stress cytoskeleton extracellular matrix (ECM) mechanical signaling mechano-reciprocity Research Paper/Report RHOA ROCK mechano-reciprocity extracellular matrix (ECM) ROCK actomyosin tension cytoskeleton compressive stress mechanical signaling RHOA
ISSN:	2154-1248, 2154-1256, 2154-1256
Online Access:	Get full text
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