Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies

Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associate...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clinical pharmacology and therapeutics Ročník 101; číslo 4; s. 491
Hlavní autoři: Lanvers-Kaminsky, C, Zehnhoff-Dinnesen, Ag Am, Parfitt, R, Ciarimboli, G
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.04.2017
Témata:
Aminoglycosides - adverse effects
Animals
Antineoplastic Agents - adverse effects
Child
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - genetics
Drug-Related Side Effects and Adverse Reactions - prevention & control
Ear - physiopathology
Hearing Loss - chemically induced
Hearing Loss - epidemiology
Hearing Loss - genetics
Hearing Loss - physiopathology
Hearing Loss - prevention & control
Humans
Pharmacogenetics
ISSN:1532-6535, 1532-6535
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1532-6535
1532-6535
DOI:10.1002/cpt.603